Search Results - "Ohm, Joyce E"

Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency‐Associated Genes by Mali, Prashant, Chou, Bin‐Kuan, Yen, Jonathan, Ye, Zhaohui, Zou, Jizhong, Dowey, Sarah, Brodsky, Robert A., Ohm, Joyce E., Yu, Wayne, Baylin, Stephen B., Yusa, Kosuke, Bradley, Allan, Meyers, David J., Mukherjee, Chandrani, Cole, Philip A., Cheng, Linzhao

“…We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the…”
Get full text

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation by Pruitt, Kevin, Zinn, Rebekah L, Ohm, Joyce E, McGarvey, Kelly M, Kang, Sung-Hae L, Watkins, D Neil, Herman, James G, Baylin, Stephen B

“…The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through…”
Get full text

Stem Cell Chromatin Patterns: An Instructive Mechanism for DNA Hypermethylation? by Ohm, Joyce E., Baylin, Stephen B.

“…Epigenetic gene silencing, and associated promoter CpG island DNA hypermethylation, is an alternative mechanism to mutations by which tumor suppressor genes…”
Get full text

PcG proteins, DNA methylation, and gene repression by chromatin looping by Tiwari, Vijay K, McGarvey, Kelly M, Licchesi, Julien D F, Ohm, Joyce E, Herman, James G, Schübeler, Dirk, Baylin, Stephen B

“…Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large…”
Get full text

Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer by AMANN, Joseph, KALYANKRISHNA, Shailaja, KIM, Young H, POLLACK, Jonathan R, YANAGISAWA, Kiyoshi, GAZDAR, Adi, MINNA, John D, KURIE, Jonathan M, CARBONE, David P, MASSION, Pierre P, OHM, Joyce E, GIRARD, Luc, SHIGEMATSU, Hisayuki, PEYTON, Michael, JUROSKE, Denise, YUHUI HUANG, SALMON, J. Stuart

“…Epidermal growth factor receptor (EGFR) is occasionally amplified and/or mutated in non-small cell lung cancer (NSCLC) and can be coexpressed with other…”
Get full text

Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation by Dikov, Mikhail M, Ohm, Joyce E, Ray, Neelanjan, Tchekneva, Elena E, Burlison, Jared, Moghanaki, Drew, Nadaf, Sorena, Carbone, David P

“…Impaired Ag-presenting function in dendritic cells (DCs) due to abnormal differentiation is an important mechanism of tumor escape from immune control. A major…”
Get full text

CDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma by Martin, Jeffrey C., Sims, Jennie R., Gupta, Ajay, Hagoel, Tamara J., Gao, Lingqiu, Lynch, Miranda L., Woloszynska, Anna, Melendy, Thomas, Kane, Jeremy F., Kuechle, Joseph, Ohm, Joyce E.

“…Ewing sarcoma is the second most common bone malignancy in children and adolescents. In recent years, a large body of evidence has emerged that suggests Ewing…”
Get full text

Environmental Exposures, the Epigenome, and African American Women’s Health by Ohm, Joyce E.

“…Stress is a common feature of modern life, but both the extent of exposure to stressors and the downstream effects of these stress exposures can vary…”
Get full text

Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? by Baylin, Stephen B, Ohm, Joyce E

“…Chromatin alterations have been associated with all stages of tumour formation and progression. The best characterized are epigenetically mediated…”
Get full text

Role of endolysosome function in iron metabolism and brain carcinogenesis by Halcrow, Peter W., Lynch, Miranda L., Geiger, Jonathan D., Ohm, Joyce E.

“…Iron, the most abundant metal in human brain, is an essential microelement that regulates numerous cellular mechanisms. Some key physiological roles of iron…”
Get full text

Exploiting Replication Stress as a Novel Therapeutic Intervention by Martin, Jeffrey C, Hoegel, Tamara J, Lynch, Miranda L, Woloszynska, Anna, Melendy, Thomas, Ohm, Joyce E

“…Ewing sarcoma is an aggressive pediatric tumor of the bone and soft tissue. The current standard of care is radiation and chemotherapy, and patients generally…”
Get full text

Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines by Adachi, Yasushi, Lee, Choon–Taek, Coffee, Keith, Yamagata, Noboru, Ohm, Joyce E., Park, Kyung–Ho, Dikov, Mikhail M., Nadaf, Sorena R., Arteaga, Carlos L., Carbone, David P.

“…Background & Aims: Insulin-like growth factor (IGF)-I receptor (IGF-Ir) signaling is required for maintenance of growth and tumorigenicity of several tumor…”
Get full text

Establishing a role for environmental toxicant exposure induced epigenetic remodeling in malignant transformation by Humphrey, Kristen M., Pandey, Sumali, Martin, Jeffery, Hagoel, Tamara, Grand’Maison, Anne, Ohm, Joyce E.

“…Humans are exposed to a wide variety of environmental exposures throughout their lifespan. These include both naturally occurring toxins and chemical toxicants…”
Get full text

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing by Baylin, Stephen B, Ohm, Joyce E, McGarvey, Kelly M, Yu, Xiaobing, Cheng, Linzhao, Schuebel, Kornel E, Cope, Leslie, Mohammad, Helai P, Chen, Wei, Daniel, Vincent C, Yu, Wayne, Berman, David M, Jenuwein, Thomas, Pruitt, Kevin, Sharkis, Saul J, Watkins, D Neil, Herman, James G

“…Adult cancers may derive from stem or early progenitor cells. Epigenetic modulation of gene expression is essential for normal function of these early cells…”
Get full text

Mtgr1 Is a Transcriptional Corepressor That Is Required for Maintenance of the Secretory Cell Lineage in the Small Intestine by Amann, Joseph M., Chyla, Brenda J. Irvin, Ellis, Tiffany C., Martinez, Andres, Moore, Amy C., Franklin, Jeffrey L., McGhee, Laura, Meyers, Shari, Ohm, Joyce E., Luce, K. Scott, Ouelette, Andre J., Washington, M. Kay, Thompson, Mary Ann, King, Dana, Gautam, Shiva, Coffey, Robert J., Whitehead, Robert H., Hiebert, Scott W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells by Raza, Shaneabbas, Ohm, Joyce E., Dhasarathy, Archana, Schommer, Jared, Roche, Conor, Hammer, Kimberly D. P., Ghribi, Othman

“…Estrogen is synthesized from cholesterol and high cholesterol levels are suggested to be associated with increased risk of estrogen receptor(ER)-positive…”
Get full text

MPP+ decreases store-operated calcium entry and TRPC1 expression in Mesenchymal Stem Cell derived dopaminergic neurons by Sun, Yuyang, Selvaraj, Senthil, Pandey, Sumali, Humphrey, Kristen M., Foster, James D., Wu, Min, Watt, John A., Singh, Brij B., Ohm, Joyce E.

“…Parkinson’s disease is a neurodegenerative disorder involving the progressive loss of dopaminergic neurons (DNs), with currently available therapeutics, such…”
Get full text

Effects of Maternal Vitamin D Supplementation on the Maternal and Infant Epigenome by Anderson, Cindy M, Gillespie, Shannon L, Thiele, Doria K, Ralph, Jody L, Ohm, Joyce E

“…Mothers and infants are at high risk for inadequate vitamin D status. Mechanisms by which vitamin D may affect maternal and infant DNA methylation are poorly…”
Get more information

First trimester vitamin D status and placental epigenomics in preeclampsia among Northern Plains primiparas by Anderson, Cindy M., Ralph, Jody L., Johnson, LuAnn, Scheett, Angela, Wright, Michelle L., Taylor, Jacquelyn Y., Ohm, Joyce E., Uthus, Eric

“…As maternal vitamin D status has been associated with preeclampsia, the purpose of this study was to determine variations in DNA methylation patterns and…”
Get full text

A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations by Tiwari, Vijay K, Cope, Leslie, McGarvey, Kelly M, Ohm, Joyce E, Baylin, Stephen B

“…We describe construction of a novel modification, "6C," of chromatin looping assays that allows specific proteins that may mediate long-range chromatin…”
Get full text