Search Results - "Ohlemiller, Kevin K"
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Application of Mouse Models to Research in Hearing and Balance
Published in Journal of the Association for Research in Otolaryngology (01-12-2016)“…Laboratory mice ( Mus musculus ) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization,…”
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Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses
Published in The Journal of neuroscience (05-06-2019)“…Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse…”
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Contributions of mouse models to understanding of age- and noise-related hearing loss
Published in Brain research (26-05-2006)“…Once an oddity, mice have become the most widely used hearing research model. Their value for research in noise-induced hearing loss (NIHL) stems from their…”
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A critical evaluation of "leakage" at the cochlear blood-stria-barrier and its functional significance
Published in Frontiers in molecular neuroscience (29-02-2024)“…The blood-labyrinth-barrier (BLB) is a semipermeable boundary between the vasculature and three separate fluid spaces of the inner ear, the perilymph, the…”
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Lack of Fractalkine Receptor on Macrophages Impairs Spontaneous Recovery of Ribbon Synapses After Moderate Noise Trauma in C57BL/6 Mice
Published in Frontiers in neuroscience (13-06-2019)“…Noise trauma causes loss of synaptic connections between cochlear inner hair cells (IHCs) and the spiral ganglion neurons (SGNs). Such synaptic loss can…”
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Estradiol Protects against Noise-Induced Hearing Loss and Modulates Auditory Physiology in Female Mice
Published in International journal of molecular sciences (11-11-2021)“…Recent studies have identified sex-differences in auditory physiology and in the susceptibility to noise-induced hearing loss (NIHL). We hypothesize that…”
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Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice
Published in The Journal of neuroscience (03-02-2016)“…Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular…”
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Mouse methods and models for studies in hearing
Published in The Journal of the Acoustical Society of America (01-11-2019)“…Laboratory mice have become the dominant animal model for hearing research. The mouse cochlea operates according to standard “mammalian” principles, uses the…”
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Age-related hearing loss: the status of Schuknecht's typology
Published in Current opinion in otolaryngology & head and neck surgery (01-10-2004)“…Recent developments in age-related hearing loss (ARHL) are reviewed with an emphasis on their relation to the framework advocated by Schuknecht. More than a…”
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Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background
Published in Frontiers in neuroscience (21-09-2017)“…We generated constitutive knockout mouse models for the α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits by derivation from conditional knockouts…”
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QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice
Published in Journal of the Association for Research in Otolaryngology (01-06-2016)“…We reported earlier that the endocochlear potential (EP) differs between C57BL/6J (B6) and BALB/cJ (BALB) mice, being lower in BALBs by about 10 mV (Ohlemiller…”
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Lentiviral‐Transduced Human Mesenchymal Stem Cells Persistently Express Therapeutic Levels of Enzyme in a Xenotransplantation Model of Human Disease
Published in Stem cells (Dayton, Ohio) (01-07-2008)“…Bone marrow‐derived mesenchymal stem cells (MSCs) are a promising platform for cell‐ and gene‐based treatment of inherited and acquired disorders. We recently…”
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Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B
Published in PloS one (22-08-2007)“…Mucopolysaccharidosis (MPS) IIIB (Sanfilippo Syndrome type B) is caused by a deficiency in the lysosomal enzyme N-acetyl-glucosaminidase (Naglu). Children with…”
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Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB
Published in Molecular therapy (01-05-2010)“…Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from a deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to…”
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Metabolic Adaptations to Interrupted Glycosaminoglycan Recycling
Published in The Journal of biological chemistry (23-10-2009)“…Lysosomal storage diseases (LSD) are metabolic disorders characterized by accumulation of undegraded material. The mucopolysaccharidoses (MPS) are LSDs defined…”
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Genetic disruption of fractalkine signaling leads to enhanced loss of cochlear afferents following ototoxic or acoustic injury
Published in Journal of comparative neurology (1911) (01-04-2018)“…Cochlear hair cells are vulnerable to a variety of insults like acoustic trauma and ototoxic drugs. Such injury can also lead to degeneration of spiral…”
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Mechanisms and genes in human strial presbycusis from animal models
Published in Brain research (24-06-2009)“…Abstract Schuknecht proposed a discrete form of presbycusis in which hearing loss results principally from degeneration of cochlear stria vascularis and…”
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Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response
Published in Proceedings of the National Academy of Sciences - PNAS (15-05-2007)“…Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO₂, ion, and water transport. CA IV and CA XIV are…”
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Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion
Published in The Journal of neuroscience (11-11-2015)“…Macrophages are recruited into the cochlea in response to injury caused by acoustic trauma or ototoxicity, but the nature of the interaction between…”
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Early elevation of cochlear reactive oxygen species following noise exposure
Published in Audiology & neurotology (01-09-1999)“…Reactive oxygen species (ROS) have been implicated in a growing number of neurological disease states, from acute traumatic injury to neurodegenerative…”
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