Search Results - "Ohlemiller, Kevin K"

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  1. 1

    Application of Mouse Models to Research in Hearing and Balance by Ohlemiller, Kevin K., Jones, Sherri M., Johnson, Kenneth R.

    “…Laboratory mice ( Mus musculus ) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization,…”
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    Journal Article Book Review
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    Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses by Kim, Kyunghee X, Payne, Shelby, Yang-Hood, Aizhen, Li, Song-Zhe, Davis, Bethany, Carlquist, Jason, V-Ghaffari, Babak, Gantz, Jay A, Kallogjeri, Dorina, Fitzpatrick, James A J, Ohlemiller, Kevin K, Hirose, Keiko, Rutherford, Mark A

    Published in The Journal of neuroscience (05-06-2019)
    “…Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse…”
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    Journal Article
  3. 3

    Contributions of mouse models to understanding of age- and noise-related hearing loss by Ohlemiller, Kevin K.

    Published in Brain research (26-05-2006)
    “…Once an oddity, mice have become the most widely used hearing research model. Their value for research in noise-induced hearing loss (NIHL) stems from their…”
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    Journal Article
  4. 4

    A critical evaluation of "leakage" at the cochlear blood-stria-barrier and its functional significance by Ohlemiller, Kevin K, Dwyer, Noël, Henson, Veronica, Fasman, Kaela, Hirose, Keiko

    Published in Frontiers in molecular neuroscience (29-02-2024)
    “…The blood-labyrinth-barrier (BLB) is a semipermeable boundary between the vasculature and three separate fluid spaces of the inner ear, the perilymph, the…”
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    Journal Article
  5. 5

    Lack of Fractalkine Receptor on Macrophages Impairs Spontaneous Recovery of Ribbon Synapses After Moderate Noise Trauma in C57BL/6 Mice by Kaur, Tejbeer, Clayman, Anna C, Nash, Andrew J, Schrader, Angela D, Warchol, Mark E, Ohlemiller, Kevin K

    Published in Frontiers in neuroscience (13-06-2019)
    “…Noise trauma causes loss of synaptic connections between cochlear inner hair cells (IHCs) and the spiral ganglion neurons (SGNs). Such synaptic loss can…”
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    Journal Article
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    Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice by Tong, Benton, Hornak, Aubrey J, Maison, Stéphane F, Ohlemiller, Kevin K, Liberman, M Charles, Simmons, Dwayne D

    Published in The Journal of neuroscience (03-02-2016)
    “…Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular…”
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    Journal Article
  8. 8

    Mouse methods and models for studies in hearing by Ohlemiller, Kevin K.

    “…Laboratory mice have become the dominant animal model for hearing research. The mouse cochlea operates according to standard “mammalian” principles, uses the…”
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    Journal Article
  9. 9

    Age-related hearing loss: the status of Schuknecht's typology by Ohlemiller, Kevin K

    “…Recent developments in age-related hearing loss (ARHL) are reviewed with an emphasis on their relation to the framework advocated by Schuknecht. More than a…”
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    Journal Article
  10. 10

    Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background by Morley, Barbara J, Dolan, David F, Ohlemiller, Kevin K, Simmons, Dwayne D

    Published in Frontiers in neuroscience (21-09-2017)
    “…We generated constitutive knockout mouse models for the α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits by derivation from conditional knockouts…”
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    Journal Article
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    QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice by Ohlemiller, Kevin K., Kiener, Anna L., Gagnon, Patricia M.

    “…We reported earlier that the endocochlear potential (EP) differs between C57BL/6J (B6) and BALB/cJ (BALB) mice, being lower in BALBs by about 10 mV (Ohlemiller…”
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    Journal Article
  12. 12

    Lentiviral‐Transduced Human Mesenchymal Stem Cells Persistently Express Therapeutic Levels of Enzyme in a Xenotransplantation Model of Human Disease by Meyerrose, Todd E., Roberts, Marie, Ohlemiller, Kevin K., Vogler, Carole A., Wirthlin, Louisa, Nolta, Jan A., Sands, Mark S.

    Published in Stem cells (Dayton, Ohio) (01-07-2008)
    “…Bone marrow‐derived mesenchymal stem cells (MSCs) are a promising platform for cell‐ and gene‐based treatment of inherited and acquired disorders. We recently…”
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    Journal Article
  13. 13

    Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B by Heldermon, Coy D, Hennig, Anne K, Ohlemiller, Kevin K, Ogilvie, Judith M, Herzog, Erik D, Breidenbach, Annalisa, Vogler, Carole, Wozniak, David F, Sands, Mark S

    Published in PloS one (22-08-2007)
    “…Mucopolysaccharidosis (MPS) IIIB (Sanfilippo Syndrome type B) is caused by a deficiency in the lysosomal enzyme N-acetyl-glucosaminidase (Naglu). Children with…”
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    Journal Article
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    Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB by Heldermon, Coy D, Ohlemiller, Kevin K, Herzog, Erik D, Vogler, Carole, Qin, Elizabeth, Wozniak, David F, Tan, Yun, Orrock, John L, Sands, Mark S

    Published in Molecular therapy (01-05-2010)
    “…Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from a deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to…”
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    Journal Article
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    Metabolic Adaptations to Interrupted Glycosaminoglycan Recycling by Woloszynek, Josh C., Kovacs, Atilla, Ohlemiller, Kevin K., Roberts, Marie, Sands, Mark S.

    Published in The Journal of biological chemistry (23-10-2009)
    “…Lysosomal storage diseases (LSD) are metabolic disorders characterized by accumulation of undegraded material. The mucopolysaccharidoses (MPS) are LSDs defined…”
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    Journal Article
  16. 16

    Genetic disruption of fractalkine signaling leads to enhanced loss of cochlear afferents following ototoxic or acoustic injury by Kaur, Tejbeer, Ohlemiller, Kevin K., Warchol, Mark E.

    Published in Journal of comparative neurology (1911) (01-04-2018)
    “…Cochlear hair cells are vulnerable to a variety of insults like acoustic trauma and ototoxic drugs. Such injury can also lead to degeneration of spiral…”
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    Journal Article
  17. 17

    Mechanisms and genes in human strial presbycusis from animal models by Ohlemiller, Kevin K

    Published in Brain research (24-06-2009)
    “…Abstract Schuknecht proposed a discrete form of presbycusis in which hearing loss results principally from degeneration of cochlear stria vascularis and…”
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    Journal Article Conference Proceeding
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    Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response by Ogilvie, Judith Mosinger, Ohlemiller, Kevin K, Shah, Gul N, Ulmasov, Barbara, Becker, Timothy A, Waheed, Abdul, Hennig, Anne K, Lukasiewicz, Peter D, Sly, William S

    “…Members of the carbonic anhydrase (CA) family play an important role in the regulation of pH, CO₂, ion, and water transport. CA IV and CA XIV are…”
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    Journal Article
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    Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion by Kaur, Tejbeer, Zamani, Darius, Tong, Ling, Rubel, Edwin W, Ohlemiller, Kevin K, Hirose, Keiko, Warchol, Mark E

    Published in The Journal of neuroscience (11-11-2015)
    “…Macrophages are recruited into the cochlea in response to injury caused by acoustic trauma or ototoxicity, but the nature of the interaction between…”
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    Journal Article
  20. 20

    Early elevation of cochlear reactive oxygen species following noise exposure by Ohlemiller, K K, Wright, J S, Dugan, L L

    Published in Audiology & neurotology (01-09-1999)
    “…Reactive oxygen species (ROS) have been implicated in a growing number of neurological disease states, from acute traumatic injury to neurodegenerative…”
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    Journal Article