Search Results - "Ohkubo, Tsuyako"

Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL/6 mice by Matsui, Kazuki, Tsubota, Maho, Fukushi, Saaya, Koike, Nene, Masuda, Hiroshi, Kasanami, Yoshihito, Miyazaki, Takaya, Sekiguchi, Fumiko, Ohkubo, Tsuyako, Yoshida, Shigeru, Mukai, Yutaro, Oita, Akira, Takada, Mitsutaka, Kawabata, Atsufumi

“…We tested whether genetic deletion of Cav3.2 T-type Ca2+ channels abolishes hydrogen sulfide (H2S)-mediated pain signals in mice. In Cav3.2-expressing…”
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A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Cav3.2-dependent pain by sequestering exogenous and endogenous sulfide by Sekiguchi, Fumiko, Koike, Nene, Shimada, Yasuhiro, Sugimoto, Kaho, Masuda, Hiroshi, Nakamura, Takashi, Yamaguchi, Hiroaki, Tanabe, Genzoh, Marumoto, Shinsuke, Kasanami, Yoshihito, Tsubota, Maho, Ohkubo, Tsuyako, Yoshida, Shigeru, Kawabata, Atsufumi

“…Poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132), an organogermanium, is hydrolyzed to 3-(trihydroxygermyl)propanoic acid (THGP) in aqueous solutions,…”
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Integrin α6β4 and TRPV1 channel coordinately regulate directional keratinocyte migration by Miyazaki, Ayako, Ohkubo, Tsuyako, Hatta, Mitsutoki, Ishikawa, Hiroyuki, Yamazaki, Jun

“…The directional migration of epithelial cells is crucial for wound healing. Among integrins, a family of cell adhesion receptors, integrin β4 has been assumed…”
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Tarantula Toxin ProTx-I Differentiates Between Human T-type Voltage-Gated Ca2+ Channels Cav3.1 and Cav3.2 by Ohkubo, Tsuyako, Yamazaki, Jun, Kitamura, Kenji

“…ProTx-I peptide, a venom toxin of the tarantula Thrixopelma pruriens, has been reported to interact with voltage-gated ion channels. ProTx-I reduced Ba2+…”
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Modified formalin test: characteristic biphasic pain response by Shibata, Manabu, Ohkubo, Tsuyako, Takahashi, Hiroshi, Inoki, Reizo

“…A modified formalin test in mice was investigated. The pain response curve induced by 0.5% formalin was biphasic, having 2 peaks, from 0 to 5 min (first phase)…”
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Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines by OKAMOTO, Yoshihiko, OHKUBO, Tsuyako, IKEBE, Tetsuro, YAMAZAKI, Jun

“…Several members of the transient receptor potential (TRP)-channel family are expressed in cancer cells. One, cold/menthol-sensitive TRPM8, is reportedly an…”
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Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells by Sekiguchi, Fumiko, Miyamoto, Yosuke, Kanaoka, Daiki, Ide, Hiroki, Yoshida, Shigeru, Ohkubo, Tsuyako, Kawabata, Atsufumi

“…•H2S-forming enzyme inhibition reduced T-currents in Cav3.2-transfected HEK293 cells.•Exogenous H2S enhanced T-currents when endogenous H2S formation was…”
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Regulation of substance P release mediated via prejunctional histamine H3 receptors by OHKUBO, T, SHIBATA, M, INOUE, M, KAYA, H, TAKAHASHI, H

“…The involvement of the histamine H3 receptor in the regulation of substance P release in neurogenic inflammation was studied by using rat hindpaw skin…”
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Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain by Kasanami, Yoshihito, Ishikawa, Chihiro, Kino, Takahiro, Chonan, Momoka, Toyooka, Naoki, Takashima, Yasuhiro, Iba, Yuriko, Sekiguchi, Fumiko, Tsubota, Maho, Ohkubo, Tsuyako, Yoshida, Shigeru, Kawase, Atsushi, Okada, Takuya, Kawabata, Atsufumi

“…T-type Ca2+ channels (T-channels), particularly Cav3.2 and Cav3.1 isoforms, are promising targets for treating various diseases including intractable pain…”
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T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells by OHKUBO, Tsuyako, YAMAZAKI, Jun

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Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain by Sekiguchi, Fumiko, Kawara, Yuma, Tsubota, Maho, Kawakami, Eri, Ozaki, Tomoka, Kawaishi, Yudai, Tomita, Shiori, Kanaoka, Daiki, Yoshida, Shigeru, Ohkubo, Tsuyako, Kawabata, Atsufumi

“…T-type Ca channels (T channels), particularly Cav3.2 among the 3 isoforms, play a role in neuropathic and visceral pain. We thus characterized the effects of…”
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Spinally delivered N-, P/Q- and L-type Ca2+-channel blockers potentiate morphine analgesia in mice by Fukuizumi, Tadaoki, Ohkubo, Tsuyako, Kitamura, Kenji

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Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice by Sekiguchi, Fumiko, Fujita, Tomoyo, Deguchi, Takahiro, Yamaoka, Sakura, Tomochika, Ken, Tsubota, Maho, Ono, Sumire, Horaguchi, Yamato, Ichii, Maki, Ichikawa, Mio, Ueno, Yumiko, Koike, Nene, Tanino, Tadatoshi, Nguyen, Huy Du, Okada, Takuya, Nishikawa, Hiroyuki, Yoshida, Shigeru, Ohkubo, Tsuyako, Toyooka, Naoki, Murata, Kazuya, Matsuda, Hideaki, Kawabata, Atsufumi

“…Since Cav3.2 T-type Ca2+ channels (T-channels) expressed in the primary afferents and CNS contribute to intractable pain, we explored T-channel-blocking…”
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A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Ca v 3.2-dependent pain by sequestering exogenous and endogenous sulfide by Sekiguchi, Fumiko, Koike, Nene, Shimada, Yasuhiro, Sugimoto, Kaho, Masuda, Hiroshi, Nakamura, Takashi, Yamaguchi, Hiroaki, Tanabe, Genzoh, Marumoto, Shinsuke, Kasanami, Yoshihito, Tsubota, Maho, Ohkubo, Tsuyako, Yoshida, Shigeru, Kawabata, Atsufumi

“…Poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132), an organogermanium, is hydrolyzed to 3-(trihydroxygermyl)propanoic acid (THGP) in aqueous solutions,…”
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Algogen‐specific pain processing in mouse spinal cord: differential involvement of voltage‐dependent Ca 2+ channels in synaptic transmission by Kato, Akemi, Ohkubo, Tsuyako, Kitamura, Kenji

“…The effects of intrathecal (i.t.) administration of N‐, P/Q‐ or L‐type voltage‐dependent Ca 2+ ‐channel blockers were tested in two pain models involving…”
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Molecular and immunohistochemical studies in expression of voltage-dependent Ca2+ channels in dorsal root ganglia from streptozotocin-induced diabetic mice by Umeda, Mariko, Ohkubo, Tsuyako, Ono, Jun, Fukuizumi, Tadaoki, Kitamura, Kenji

“…We have recently demonstrated that intrathecal injection of a selective P/Q-type blocker of the voltage-dependent Ca(2+) channels (VDCCs) significantly…”
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Genetic deletion of Ca v 3.2 T-type calcium channels abolishes H 2 S-dependent somatic and visceral pain signaling in C57BL/6 mice by Matsui, Kazuki, Tsubota, Maho, Fukushi, Saaya, Koike, Nene, Masuda, Hiroshi, Kasanami, Yoshihito, Miyazaki, Takaya, Sekiguchi, Fumiko, Ohkubo, Tsuyako, Yoshida, Shigeru, Mukai, Yutaro, Oita, Akira, Takada, Mitsutaka, Kawabata, Atsufumi

“…We tested whether genetic deletion of Ca 3.2 T-type Ca channels abolishes hydrogen sulfide (H S)-mediated pain signals in mice. In Ca 3.2-expressing…”
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Algogen-specific pain processing in mouse spinal cord: differential involvement of voltage-dependent Ca(2+) channels in synaptic transmission by Kato, Akemi, Ohkubo, Tsuyako, Kitamura, Kenji

“…1. The effects of intrathecal (i.t.) administration of N-, P/Q- or L-type voltage-dependent Ca(2+)-channel blockers were tested in two pain models involving…”
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Mechanisms Mediating the Vasorelaxing Action of Eugenol, a Pungent Oil, on Rabbit Arterial Tissue by Hiroaki, Nishijima, Ryuji, Uchida, Kimiko, Kameyama, Nozomi, Kawakami, Tsuyako, Ohkubo, Kenji, Kitamura

“…The inhibitory actions of eugenol on intracellular Ca2+ concentration ([Ca2+]i and the contractions induced by excess extracellular K+ concentration ([K+]o) in…”
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Specific expression of salivary maxi-K channel variant is augmented in diabetic mice by Okamura, Kazuhiko, Kato, Kenichi, Uchida, Ryuji, Ohkubo, Tsuyako, Taniguchi, Kunihisa, Yamazaki, Jun

“…Abstract Background and objective A genetically diabetic mouse strain ( db / db ) exhibits severe obesity and a syndrome resembling human non-insulin-dependent…”
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