Search Results - "Ohkawara, Susumu"

Species-Specific Activation of Transient Receptor Potential Ankyrin 1 by Phthalic Acid Monoesters by Mori, Yoko, Aoki, Akira, Okamoto, Yoshinori, Isobe, Takashi, Ohkawara, Susumu, Hanioka, Nobumitsu, Tanaka-Kagawa, Toshiko, Jinno, Hideto

“…Phthalic acid (PA) diesters are widely used in consumer products, as plasticizers, and are ubiquitous environmental pollutants. There is a growing concern…”
Get full text

Regioselective Glucuronidation of Flavones at C5, C7, and C4′ Positions in Human Liver and Intestinal Microsomes: Comparison among Apigenin, Acacetin, and Genkwanin by Hanioka, Nobumitsu, Tanaka-Kagawa, Toshiko, Mori, Yoko, Ikushiro, Shinichi, Jinno, Hideto, Ohkawara, Susumu, Isobe, Takashi

“…Flavones, which are distributed in a variety of plants and foods in nature, possess significant biological activities, including antitumor and…”
Get full text

Isoform-Specific Quantification of Human Bitter Taste Receptor Transcripts Using Real-Time PCR Analysis by Mori, Yoko, Aoki, Akira, Okamoto, Yoshinori, Isobe, Takashi, Ohkawara, Susumu, Hanioka, Nobumitsu, Tanaka-Kagawa, Toshiko, Jinno, Hideto

“…Bitter taste receptors (TAS2Rs) are expressed by oral cavity cells in mammals and classically function as sensors for bitter compounds. There are 25 functional…”
Get full text

Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality by Mori, Yoko, Tanaka-Kagawa, Toshiko, Tahara, Maiko, Kawakami, Tsuyoshi, Aoki, Akira, Okamoto, Yoshinori, Isobe, Takashi, Ohkawara, Susumu, Hanioka, Nobumitsu, Azuma, Kenichi, Sakai, Shinobu, Jinno, Hideto

“…Transient Receptor Potential Ankyrin 1 (TRPA1), which is expressed in the airways, has causative and exacerbating roles in respiratory diseases. TRPA1 is known…”
Get full text

Wogonin glucuronidation in liver and intestinal microsomes of humans, monkeys, dogs, rats, and mice by Hanioka, Nobumitsu, Isobe, Takashi, Tanaka-Kagawa, Toshiko, Ohkawara, Susumu

“…Wogonin, one of the flavonoids isolated from Scutellaria baicalensis, exhibits some beneficial bioactivities, including anti-inflammatory and anticancer…”
Get full text

In vitro glucuronidation of bisphenol A in liver and intestinal microsomes: interspecies differences in humans and laboratory animals by Hanioka, Nobumitsu, Isobe, Takashi, Tanaka-Kagawa, Toshiko, Jinno, Hideto, Ohkawara, Susumu

“…Bisphenol A (BPA) is an endocrine-disrupting chemical, and is predominantly metabolized into glucuronide in mammals. The present study was conducted in order…”
Get full text

Naringenin glucuronidation in liver and intestine microsomes of humans, monkeys, rats, and mice by Isobe, Takashi, Ohkawara, Susumu, Ochi, Sadayuki, Tanaka-Kagawa, Toshiko, Jinno, Hideto, Hanioka, Nobumitsu

“…Naringenin, a flavanone found in citrus fruits, is mainly metabolized into glucuronide(s) by UDP-glucuronosyltransferase (UGT) enzymes in mammals. In the…”
Get full text

Favipiravir biotransformation in liver cytosol: Species and sex differences in humans, monkeys, rats, and mice by Hanioka, Nobumitsu, Saito, Keita, Isobe, Takashi, Ohkawara, Susumu, Jinno, Hideto, Tanaka‐Kagawa, Toshiko

“…Favipiravir is an antiviral agent effective against several RNA viruses that is converted into an inactive oxidative metabolite (M1), mainly by aldehyde…”
Get full text

Hydrolysis of di(2-ethylhexyl) phthalate in humans, monkeys, dogs, rats, and mice: An in vitro analysis using liver and intestinal microsomes by Hanioka, Nobumitsu, Isobe, Takashi, Ohkawara, Susumu, Ochi, Sadayuki, Tanaka-Kagawa, Toshiko, Jinno, Hideto

“…Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that is rapidly metabolized to mono(2-ethylhexyl) phthalate (MEHP), an active metabolite, in…”
Get full text

Regioselective glucuronidation of daidzein in liver and intestinal microsomes of humans, monkeys, rats, and mice by Hanioka, Nobumitsu, Ohkawara, Susumu, Isobe, Takashi, Ochi, Sadayuki, Tanaka-Kagawa, Toshiko, Jinno, Hideto

“…Daidzein, one of the major soy isoflavones, has a number of beneficial bioactivities for human health. It is mainly metabolized into 7- and/or 4′-glucuronides…”
Get full text

Disruption of zinc homeostasis and the pathogenesis of senile dementia by Kawahara, Masahiro, Mizuno, Dai, Koyama, Hironari, Konoha, Keiko, Ohkawara, Susumu, Sadakane, Yutaka

“…Zinc (Zn) is an essential trace element that is abundantly present in the brain. Although Zn plays crucial roles in learning and memory, numerous studies have…”
Get full text

Glucuronidation of 4-tert-octylphenol in humans, monkeys, rats, and mice: an in vitro analysis using liver and intestine microsomes by Hanioka, Nobumitsu, Isobe, Takashi, Ohkawara, Susumu, Tanaka-Kagawa, Toshiko, Jinno, Hideto

“…4- tert -Octylphenol (4-tOP) is an endocrine-disrupting chemical. It is mainly metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in…”
Get full text

Methylglyoxal activates the human transient receptor potential ankyrin 1 channel by Ohkawara, Susumu, Tanaka-Kagawa, Toshiko, Furukawa, Yoko, Jinno, Hideto

“…Methylglyoxal (MG) is an endogenous carbonyl compound that is produced in large quantity under hyperglycemic conditions, which are believed to contribute to…”
Get full text

Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia by Mizuno, Dai, Konoha-Mizuno, Keiko, Mori, Miwako, Sadakane, Yutaka, Koyama, Hironari, Ohkawara, Susumu, Kawahara, Masahiro

“…Carnosine (β-alanyl- l -histidine) is a small dipeptide with numerous beneficial effects, including the maintenance of the acid-base balance, antioxidant…”
Get full text

Hepatic glucuronidation of 4-tert-octylphenol in humans: inter-individual variability and responsible UDP-glucuronosyltransferase isoforms by Isobe, Takashi, Ohkawara, Susumu, Tanaka-Kagawa, Toshiko, Jinno, Hideto, Hanioka, Nobumitsu

“…4- tert -Octylphenol (4-tOP) is an endocrine-disrupting chemical. It is mainly metabolized into glucuronide by UDP-glucuronosyltransferase (UGT) enzymes in…”
Get full text

d-Histidine and l-histidine attenuate zinc-induced neuronal death in GT1-7 cells by Kawahara, Masahiro, Sadakane, Yutaka, Koyama, Hironari, Konoha, Keiko, Ohkawara, Susumu

“…Although zinc (Zn) is an essential trace element, excess Zn causes neuronal death following transient global ischemia and plays a central role in the…”
Get full text

Activation of the Human Transient Receptor Potential Vanilloid Subtype 1 by Essential Oils by Ohkawara, Susumu, Tanaka-Kagawa, Toshiko, Furukawa, Yoko, Nishimura, Tetsuji, Jinno, Hideto

“…Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel activated by capsaicin. TRPV1 is expressed not only on human sensory…”
Get full text

Involvement of trace elements in the pathogenesis of prion diseases by Mizuno, Dai, Koyama, Hironari, Ohkawara, Susumu, Sadakane, Yutaka, Kawahara, Masahiro

“…Prion diseases are progressive neurodegenerative diseases that are associated with conformational changes that convert normal cellular prion protein (PrP(C))…”
Get more information

A Case of Squamous Cell Carcinoma of the Breast by Katsumori, Takashi, Ohshima, Hisami, Ohkawara, Susumu

“…A 67-year-old woman presented with a 3 cm palpable mass in the lower lateral quadrant of her right breast. Mammography and ultrasonography showed a mass with…”
Get more information

Quantitative and antioxidative behavior of Trolox in rats' blood and brain by HPLC-UV and SMFIA-CL methods by Wada, Mitsuhiro, Wada, Misato, Ikeda, Rie, Fuchigami, Yuki, Koyama, Hironari, Ohkawara, Susumu, Kawakami, Shigeru, Kuroda, Naotaka, Nakashima, Kenichiro

“…Trolox, a water‐soluble vitamin E analogue has been used as a positive control in Trolox equivalent antioxidant capacity and oxygen radical antioxidant…”
Get full text