Search Results - "Ohishi, Hiroaki"

Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos by Maenohara, Shoji, Unoki, Motoko, Toh, Hidehiro, Ohishi, Hiroaki, Sharif, Jafar, Koseki, Haruhiko, Sasaki, Hiroyuki

“…The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed during gametogenesis and preimplantation development. It was…”
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The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes by Uehara, Ryuji, Au Yeung, Wan Kin, Toriyama, Keisuke, Ohishi, Hiroaki, Kubo, Naoki, Toh, Hidehiro, Suetake, Isao, Shirane, Kenjiro, Sasaki, Hiroyuki

“…Establishment of a proper DNA methylation landscape in mammalian oocytes is important for maternal imprinting and embryonic development. De novo DNA…”
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Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells by Kubo, Naoki, Uehara, Ryuji, Uemura, Shuhei, Ohishi, Hiroaki, Shirane, Kenjiro, Sasaki, Hiroyuki

“…DNA methyltransferase 3A (DNMT3A) and its catalytically inactive cofactor DNA methyltransferase 3-Like (DNMT3L) proteins form functional heterotetramers to…”
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The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes by Kibe, Kanako, Shirane, Kenjiro, Ohishi, Hiroaki, Uemura, Shuhei, Toh, Hidehiro, Sasaki, Hiroyuki

“…DNA methylation at CG sites is important for gene regulation and embryonic development. In mouse oocytes, de novo CG methylation requires preceding…”
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STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity by Ohishi, Hiroaki, Shimada, Seiru, Uchino, Satoshi, Li, Jieru, Sato, Yuko, Shintani, Manabu, Owada, Hitoshi, Ohkawa, Yasuyuki, Pertsinidis, Alexandros, Yamamoto, Takashi, Kimura, Hiroshi, Ochiai, Hiroshi

“…Transcription is a dynamic process. To detect the dynamic relationship among protein clusters of RNA polymerase II and coactivators, gene loci, and…”
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Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states by Tomimatsu, Kosuke, Fujii, Takeru, Bise, Ryoma, Hosoda, Kazufumi, Taniguchi, Yosuke, Ochiai, Hiroshi, Ohishi, Hiroaki, Ando, Kanta, Minami, Ryoma, Tanaka, Kaori, Tachibana, Taro, Mori, Seiichi, Harada, Akihito, Maehara, Kazumitsu, Nagasaki, Masao, Uchida, Seiichi, Kimura, Hiroshi, Narita, Masashi, Ohkawa, Yasuyuki

“…Cell states are regulated by the response of signaling pathways to receptor ligand-binding and intercellular interactions. High-resolution imaging has been…”
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Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development by Ishiuchi, Takashi, Ohishi, Hiroaki, Sato, Tetsuya, Kamimura, Satoshi, Yorino, Masayoshi, Abe, Shusaku, Suzuki, Atsushi, Wakayama, Teruhiko, Suyama, Mikita, Sasaki, Hiroyuki

“…Placental development is a key event in mammalian reproduction and embryogenesis. However, the molecular basis underlying placental development is not fully…”
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Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia by Morikawa, Takuya, Ohishi, Hiroaki, Kosaka, Kengo, Shimojo, Tomofumi, Nagano, Akihiro, Taniguchi, Itsuki, Fujioka, Ryuta, Moriyama, Kosei, Unoki, Motoko, Takahashi, Masatomo, Nakao, Motonao, Izumi, Yoshihiro, Bamba, Takeshi, Sasaki, Hiroyuki, Miura, Shiroh, Shibata, Hiroki

“…We have previously reported a novel homozygous 4-bp deletion in DDHD1 as the responsible variant for spastic paraplegia type 28 (SPG28; OMIM#609340). The…”
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Characterization of genetic‐origin‐dependent monoallelic expression in mouse embryonic stem cells by Ohishi, Hiroaki, Au Yeung, Wan Kin, Unoki, Motoko, Ichiyanagi, Kenji, Fukuda, Kei, Maenohara, Shoji, Shirane, Kenjiro, Chiba, Hatsune, Sado, Takashi, Sasaki, Hiroyuki

“…Monoallelic gene expression occurs in various mammalian cells and can be regulated genetically, epigenetically and/or stochastically. We identified 145…”
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Phase II/III, randomized, double-blind, parallel-group study of monthly delayed-release versus daily immediate-release risedronate tablets in Japanese patients with involutional osteoporosis by Soen, Satoshi, Kishimoto, Hideaki, Hagino, Hiroshi, Sone, Teruki, Ohishi, Hiroaki, Fujimoto, Tsukasa, Sasaki, Emma, Tanaka, Sakae, Sugimoto, Toshitsugu

“…Absorption of oral immediate-release (IR) risedronate tablets is reduced by food intake, thus a delayed-release (DR) tablet has been developed to overcome the…”
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Image Analysis Protocol for DNA/RNA/Immunofluorescence (IF)-seqFISH Data by Ohishi, Hiroaki, Ochiai, Hiroshi

“…Imaging-based spatial multi-omics technologies facilitate the analysis of higher-order genomic structures, gene transcription, and the localization of proteins…”
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Organization of transcription and 3D genome as revealed by live-cell imaging by Ochiai, Hiroshi, Ohishi, Hiroaki, Sato, Yuko, Kimura, Hiroshi

“…Higher-order genomic structures play a critical role in regulating gene expression by influencing the spatial proximity of promoters and enhancers. Live-cell…”
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Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring by Inoguchi, Yukihiro, Ichiyanagi, Kenji, Ohishi, Hiroaki, Maeda, Yasutaka, Sonoda, Noriyuki, Ogawa, Yoshihiro, Inoguchi, Toyoshi, Sasaki, Hiroyuki

“…Exposure to maternal diabetes during pregnancy results in diabetes in offspring, but its underlying mechanisms are unclear. Here, we investigated the phenotype…”
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Efficacy, tolerability and safety of once-monthly administration of 75 mg risedronate in Japanese patients with involutional osteoporosis: A comparison with a 2.5 mg once-daily dosage regimen by Hagino, Hiroshi, Kishimoto, Hideaki, Ohishi, Hiroaki, Horii, Sayako, Nakamura, Toshitaka

“…Abstract Oral risedronate has been shown to be effective in the treatment of osteoporosis when administered once-daily or once-weekly in Japan. This…”
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Efficacy, tolerability and safety of once-monthly administration of 75mg risedronate in Japanese patients with involutional osteoporosis: A comparison with a 2.5mg once-daily dosage regimen by Hagino, Hiroshi, Kishimoto, Hideaki, Ohishi, Hiroaki, Horii, Sayako, Nakamura, Toshitaka

“…Oral risedronate has been shown to be effective in the treatment of osteoporosis when administered once-daily or once-weekly in Japan. This randomized,…”
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Su1789 ORAL ALPHA 4 BETA 7 INTEGRIN ANTAGONIST EA1080 DEMONSTRATES SUSTAINED TARGET ENGAGEMENT IN A FIRST-IN-HUMAN STUDY IN HEALTHY MALE PARTICIPANTS by Seki, Tatsunori, Yazawa, Yusuke, Watanabe, Emi, Ohishi, Hiroaki, Ueo, Harumasa, Uo, Michihide, Tsuruta, Atsushi, Takeuchi, Yutaka, Lorch, Ulrike

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