Search Results - "Ohi, N"

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases by Hayakawa, F, Sugimoto, K, Harada, Y, Hashimoto, N, Ohi, N, Kurahashi, S, Naoe, T

“…Signal transduction and activator of transcription (STAT) proteins are extracellular ligand-responsive transcription factors that mediate cell proliferation,…”
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463PEvaluation of pharmacodynamic (PD) biomarkers in advanced cancer patients treated with oxidative phosphorylation (OXPHOS) inhibitor, OPC-317 (OPC) by Eu, J Q, Yadav, K, Lim, Y -C, Hirpara, J, Kong, L R, Ng, Z C, Lee, V K, Lee, S C, Tan, D S, Soo, R A, Chee, C E, Yong, W P, Sundar, R, Lim, J S, Wang, L, Ohi, N, Tsunoda, T, Pervaiz, S, Goh, B -C, Wong, A L

“…Abstract Background We reported that metabolic reprogramming towards OXPHOS-induced drug resistance in oncogene-addicted tumors. OXPHOS is an attractive drug…”
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463P - Evaluation of pharmacodynamic (PD) biomarkers in advanced cancer patients treated with oxidative phosphorylation (OXPHOS) inhibitor, OPC-317 (OPC) by Eu, J.Q., Yadav, K., Lim, Y.-C., Hirpara, J., Kong, L.R., Ng, Z.C., Lee, V.K., Lee, S.C., Tan, D.S., Soo, R.A., Chee, C.E., Yong, W.P., Sundar, R., Lim, J.S., Wang, L., Ohi, N., Tsunoda, T., Pervaiz, S., Goh, B.-C., Wong, A.L.

“…We reported that metabolic reprogramming towards OXPHOS-induced drug resistance in oncogene-addicted tumors. OXPHOS is an attractive drug target but clinical…”
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Evaluation of pharmacodynamic (PD) biomarkers in advanced cancer patients treated with oxidative phosphorylation (OXPHOS) inhibitor, OPC-317 (OPC) by Eu, J.Q., Yadav, K., Lim, Y.-C., Hirpara, J., Kong, L.R., Ng, Z.C., Lee, V.K., Lee, S.C., Tan, D.S., Soo, R.A., Chee, C.E., Yong, W.P., Sundar, R., Lim, J.S., Wang, L., Ohi, N., Tsunoda, T., Pervaiz, S., Goh, B.-C., Wong, A.L.

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Novel Calcium Antagonists with Both Calcium Overload Inhibition and Antioxidant Activity. 2. Structure−Activity Relationships of Thiazolidinone Derivatives by Kato, Tatsuya, Ozaki, Tomokazu, Tamura, Kazuhiko, Suzuki, Yoshiyuki, Akima, Michitaka, Ohi, Nobuhiro

“…CP-060 (1), 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-[3-[N-methyl-N-[2-[3,4-(methylenedioxy)phenoxy]ethyl]amino]propyl]-1,3-thiazolidin-4-one, is a novel type…”
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Maintenance of Bad Phosphorylation Prevents Apoptosis of Rat Hepatic Sinusoidal Endothelial Cells in Vitro and in Vivo by Ohi, Naoto, Nishikawa, Yuji, Tokairin, Takuo, Yamamoto, Yohei, Doi, Yuko, Omori, Yasufumi, Enomoto, Katsuhiko

“…To elucidate the mechanism of apoptosis of liver sinusoidal endothelial cells (SECs), we examined the phosphorylation status of Bad and its upstream signaling…”
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Light absorption of Isochrysis galbana (prymnesiophyceae) under a day-night cycle with ultraviolet radiation by OHI, Nobuaki, MIZOBUCHI, Akemi, TAGUCHI, Satoru

“…Diel variation in chlorophyll a-specific absorption coefficients, a sub( ph) (lambda), m super(2) (mg chl a) super(-1), was examined to study the effect of…”
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Antirheumatic Agents:  Novel Methotrexate Derivatives Bearing a Benzoxazine or Benzothiazine Moiety by Matsuoka, Hiroharu, Ohi, Nobuhiro, Mihara, Masahiko, Suzuki, Hiroshi, Miyamoto, Katsuhito, Maruyama, Noriaki, Tsuji, Keiichiro, Kato, Nobuaki, Akimoto, Toshio, Takeda, Yasuhisa, Yano, Keiichi, Kuroki, Toshio

“…Novel methotrexate (MTX) derivatives bearing dihydro-2H-1,4-benzothiazine or dihydro-2H-1,4-benzoxazine were synthesized and tested for in vitro…”
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A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region by Ohi, N, Tokunaga, A, Tsunoda, H, Nakano, K, Haraguchi, K, Oda, K, Motoyama, N, Nakajima, T

“…The adenovirus E1B19K protein inhibits apoptosis induced by E1A and other divergent signals. The cellular proteins that interact with E1B19K have been analyzed…”
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Semisynthetic β-Lactam Antibiotics. IV. Synthesis and Antibacterial Activity of New Ureidocephalosporin and Ureidocephamycin Derivatives Containing a Catechol Moiety or Its Acetate by OHI, NOBUHIRO, AOKI, BUNYA, SHINOZAKI, TEIZO, MORO, KANZI, KUROKI, TOSHIO, NOTO, TAKAO, NEHASHI, TOSHIYUKI, MATSUMOTO, MASAHIKO, OKAZAKI, HIROSHI, MATSUNAGA, ISAO

“…New ureidocephalosporin and ureidocephamycin derivatives containing a catechol moiety or its acetate were prepared and their minimum inhibitory concentration…”
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Diel patterns in light absorption and absorption efficiency factors of Isochrysis galbana (Prymnesiophyceae) by Ohi, N, Ishiwata, Y, Taguchi, S

“…The chl a specific absorption coefficients [a* ( lambda ), m super(2).mg chl a super(-) super(1)] were examined in chemostat culture of the Prymnesiophyceae…”
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Improved synthetic methods of CP-060S, a novel cardioprotective drug by Kato, Tatsuya, Ozaki, Tomokazu, Ohi, Nobuhiro

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MR imaging evaluation of the spine with titanium alloy pedicular screw fixation by Iwasaku, Y, Yamaguchi, Y, Ohi, N, Emoto, K, Kusakabe, T

“…We studied the cases of 60 patients who underwent magnetic resonance (MR) imaging evaluation after fixation with the titanium alloy pedicular screw system…”
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Semisynthetic beta-lactam antibiotics. V. Metabolism in vitro of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1- ureido-2-phenylacetamidopenicillanic acid (AO-1100) and surveys on the metabolites by Ohi, N, Ohsawa, Y, Nehashi, T, Aoki, B, Okazaki, A

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Diel Patterns in Chlorophyll a Specific Absorption Coefficient and Absorption Efficiency Factor of Picoplankton by Ohi, Nobuaki, Saito, Hiroaki, Taguchi, Satoru

“…Diel patterns in the chlorophyll a specific absorption coefficient of surface picoplankton, a*^sub pico^ (γ) (m^sup 2^·[mg chlorophyll a]^sup -1^), were…”
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Novel Calcium Antagonists with Both Calcium Overload Inhibition and Antioxidant Activity. 1. 2-(3,5-Di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinones by Kato, Tatsuya, Ozaki, Tomokazu, Tamura, Kazuhiko, Suzuki, Yoshiyuki, Akima, Michitaka, Ohi, Nobuhiro

“…A series of 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinones was synthesized in order to explore novel calcium antagonists with potent…”
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Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones by Yamaguchi, Masahisa, Kamei, Kenshi, Koga, Takaki, Akima, Michitaka, Kuroki, Toshio, Ohi, Nobuhiro

“…A number of 4-substituted 2-[omega-(1-imidazolyl)alkyl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2…”
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Practical Synthesis of Novel Cardioprotective Drug, CP-060S by Kato, Tatsuya, Ozaki, Tomokazu, Tsuzuki, Kouichi, Ohi, Nobuhiro

“…A practical synthesis of a novel cardioprotective drug, CP-060S, is described. Key intermediate (S)-7, a chiral carboxylic acid, was prepared from…”
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Semisynthetic β-Lactam Antibiotics. V. Metabolism in Vitro of 6-[(R)-2-[3-(3, 4-Dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido] penicillanic Acid (AO-1100) and Surveys on the Metabolites by OHI, NOBUHIRO, OHSAWA, YASUJI, NEHASHI, TOSHIYUKI, AOKI, BUNYA, OKAZAKI, AKIRA

“…Metabolism of 6-[(R)-2-[3-(3, 4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido] penicillanic acid (AO-1100), a new ureidopenicillin having…”
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Degradation of Topoisomerase IIα during Adenovirus E1A-induced Apoptosis Is Mediated by the Activation of the Ubiquitin Proteolysis System by Nakajima, Takuma, Morita, Kenichi, Ohi, Naoto, Arai, Takao, Nozaki, Naohito, Kikuchi, Akihiko, Osaka, Fumio, Yamao, Fumiaki, Oda, Kinichiro

“…The human epithermoid carcinoma-derived cell line MA1, established by introduction of the adenovirus E1A 12 S cDNA linked to the mouse mammary tumor virus long…”
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