Search Results - "Ohba, Shun‐Ichi"

Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA by Nagasawa, Ikuko, Muroi, Makoto, Kawatani, Makoto, Ohishi, Tomokazu, Ohba, Shun-Ichi, Kawada, Manabu, Osada, Hiroyuki

“…The cellular thermal shift assay (CETSA) has recently been devised as a label-free method for target validation of small compounds and monitoring the thermal…”
Get more information

Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin‐like growth factor‐1 secretion by prostate stromal cells by Ohishi, Tomokazu, Abe, Hikaru, Sakashita, Chiharu, Saqib, Uzma, Baig, Mirza S., Ohba, Shun‐ichi, Inoue, Hiroyuki, Watanabe, Takumi, Shibasaki, Masakatsu, Kawada, Manabu

“…Modulation of prostate stromal cells (PrSCs) within tumor tissues is gaining attention for the treatment of solid tumors. Using our original in vitro coculture…”
Get full text

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression by Takase, Shohei, Hiroyama, Takashi, Shirai, Fumiyuki, Maemoto, Yuki, Nakata, Akiko, Arata, Mayumi, Matsuoka, Seiji, Sonoda, Takeshi, Niwa, Hideaki, Sato, Shin, Umehara, Takashi, Shirouzu, Mikako, Nishigaya, Yosuke, Sumiya, Tatsunobu, Hashimoto, Noriaki, Namie, Ryosuke, Usui, Masaya, Ohishi, Tomokazu, Ohba, Shun-ichi, Kawada, Manabu, Hayashi, Yoshihiro, Harada, Hironori, Yamaguchi, Tokio, Shinkai, Yoichi, Nakamura, Yukio, Yoshida, Minoru, Ito, Akihiro

“…Sickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations. Induction of fetal γ-globin is an established therapeutic strategy…”
Get full text

Generation and evaluation of a chimeric antibody against coxsackievirus and adenovirus receptor for cancer therapy by Sakamoto, Shuichi, Inoue, Hiroyuki, Kaneko, Mika K., Ogasawara, Satoshi, Kajikawa, Masunori, Urano, Sakiko, Ohba, Shun‐ichi, Kato, Yukinari, Kawada, Manabu

“…Coxsackievirus and adenovirus receptor (CAR) is a single‐pass transmembrane protein that is associated with adenoviral infection. CAR is involved in the…”
Get full text

Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer by Sakamoto, Shuichi, Inoue, Hiroyuki, Kohda, Yasuko, Ohba, Shun-Ichi, Mizutani, Taketoshi, Kawada, Manabu

“…Small cell lung cancer (SCLC) is a severe malignancy associated with early and widespread metastasis. To study SCLC metastasis, we previously developed an…”
Get full text

Anti-Metastatic Activity of an Anti-EGFR Monoclonal Antibody against Metastatic Colorectal Cancer with KRAS p.G13D Mutation by Ohishi, Tomokazu, Kato, Yukinari, Kaneko, Mika K, Ohba, Shun-Ichi, Inoue, Hiroyuki, Harakawa, Akiko, Kawada, Manabu

“…The now clinically-used anti-epidermal growth factor receptor (EGFR) monoclonal antibodies have demonstrated significant efficacy only in patients with…”
Get full text

Androprostamine A: a unique antiprostate cancer agent by Yamazaki, Yohko, Abe, Hikaru, Sakashita, Chiharu, Ohba, Shun-Ichi, Watanabe, Takumi, Momose, Isao, Kawada, Manabu

“…The androgen receptor (AR) is an important therapeutic target for all clinical states of prostate cancer. We screened cultured broths of microorganisms for…”
Get full text

Monotherapy with a novel intervenolin derivative, AS‐1934, is an effective treatment for Helicobacter pylori infection by Ohishi, Tomokazu, Masuda, Tohru, Abe, Hikaru, Hayashi, Chigusa, Adachi, Hayamitsu, Ohba, Shun‐ichi, Igarashi, Masayuki, Watanabe, Takumi, Mimuro, Hitomi, Amalia, Eri, Inaoka, Daniel Ken, Mochizuki, Kota, Kita, Kiyoshi, Shibasaki, Masakatsu, Kawada, Manabu

“…Background Helicobacter pylori (H. pylori) infection causes various gastrointestinal diseases including gastric cancer. Hence, eradication of this infection…”
Get full text

Metacytofilin Is a Potent Therapeutic Drug Candidate for Toxoplasmosis by Leesombun, Arpron, Iijima, Masatomi, Umeda, Kousuke, Kondoh, Daisuke, Pagmadulam, Baldorj, Abdou, Ahmed M, Suzuki, Yutaka, Ohba, Shun-Ichi, Isshiki, Kunio, Kimura, Tomoyuki, Kubota, Yumiko, Sawa, Ryuichi, Nihei, Coh-Ichi, Nishikawa, Yoshifumi

“…Abstract Background Toxoplasmosis, a parasitic disease caused by Toxoplasma gondii, is an important cause of miscarriage or adverse fetal effects, including…”
Get full text

Antitumor effects of tyropeptin‐boronic acid derivatives: New proteasome inhibitors by Momose, Isao, Abe, Hikaru, Watanabe, Takumi, Ohba, Shun‐ichi, Yamazaki, Kanami, Dan, Shingo, Yamori, Takao, Masuda, Tohru, Nomoto, Akio

“…The proteasome degrades numerous regulatory proteins that are critical for tumor growth. Thus, proteasome inhibitors are promising antitumor agents. New…”
Get full text

Leucinostatin A inhibits prostate cancer growth through reduction of insulin‐like growth factor‐I expression in prostate stromal cells by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun‐Ichi, Masuda, Tohru, Momose, Isao, Ikeda, Daishiro

“…Targeting stroma in tumor tissues is an attractive new strategy for cancer treatment. We developed in vitro coculture system, in which the growth of human…”
Get full text

In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C by Hashizume, Hideki, Takahashi, Yoshiaki, Masuda, Tohru, Ohba, Shun-ichi, Ohishi, Tomokazu, Kawada, Manabu, Igarashi, Masayuki

“…Natural lipopeptide antibiotic tripropeptin C (TPPC) revitalizes and synergistically potentiates the activities of the class of β-lactam antibiotics against…”
Get full text

Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Yoshida, Junjiro, Masuda, Tohru, Yamasaki, Manabu, Usami, Ihomi, Sakamoto, Shuichi, Abe, Hikaru, Watanabe, Takumi, Yamori, Takao, Shibasaki, Masakatsu, Nomoto, Akio

“…Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified…”
Get full text

Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis by Wada, Shun‐ichi, Usami, Ihomi, Umezawa, Yoji, Inoue, Hiroyuki, Ohba, Shun‐ichi, Someno, Tetsuya, Kawada, Manabu, Ikeda, Daishiro

“…(Cancer Sci 2010; 101: 743–750) Although cytostatin analog protein phosphatase 2A (PP2A)‐specific inhibitors are promising candidates of a new type of…”
Get full text

Rediscovery of 4‐Trehalosamine as a Biologically Stable, Mass‐Producible, and Chemically Modifiable Trehalose Analog by Wada, Shun‐ichi, Arimura, Honami, Nagayoshi, Miho, Sawa, Ryuichi, Kubota, Yumiko, Matoba, Kazuaki, Hayashi, Chigusa, Shibuya, Yuko, Hatano, Masaki, Takehana, Yasuhiro, Ohba, Shun‐ichi, Kobayashi, Yoshihiko, Watanabe, Takumi, Shibasaki, Masakatsu, Igarashi, Masayuki

“…Nonreducing disaccharide trehalose is used as a stabilizer and humectant in various products and is a potential medicinal drug, showing curative effects on the…”
Get full text

Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose by Wada, Shun-ichi, Sawa, Ryuichi, Ohba, Shun-ichi, Hayashi, Chigusa, Umekita, Maya, Shibuya, Yuko, Iijima, Kiyoko, Iwanami, Fumiki, Igarashi, Masayuki

“…Trehalose is widely used as a sweetener, humectant, and stabilizer, but is ubiquitously degraded by the enzyme trehalase expressed in a broad variety of…”
Get full text

Biological activity of intervenolin analogs with a phenyl substituent by Abe, Hikaru, Kawada, Manabu, Igarashi, Masayuki, Ohba, Shun-ichi, Hayashi, Chigusa, Sakashita, Chiharu, Watanabe, Takumi, Shibasaki, Masakatsu

“…Intervenolin analogs with a phenyl substituent at the 2- or 3-position were synthesized. The compounds ( 3 – 11 ) showed weak or no inhibitory activity toward…”
Get full text

Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment by Yoshida, Junjiro, Ohishi, Tomokazu, Abe, Hikaru, Ohba, Shun-ichi, Inoue, Hiroyuki, Usami, Ihomi, Amemiya, Masahide, Oriez, Raphael, Sakashita, Chiharu, Dan, Shingo, Sugawara, Minoru, Kawaguchi, Tokuichi, Ueno, Junko, Asano, Yuko, Ikeda, Ami, Takamatsu, Manabu, Amori, Gulanbar, Kondoh, Yasumitsu, Honda, Kaori, Osada, Hiroyuki, Noda, Tetsuo, Watanabe, Takumi, Shimizu, Takao, Shibasaki, Masakatsu, Kawada, Manabu

“…The disruption of the tumor microenvironment (TME) is a promising anti-cancer strategy, but its effective targeting for solid tumors remains unknown. Here, we…”
Get full text

In vivo imaging of proteasome inhibition using a proteasome‐sensitive fluorescent reporter by Momose, Isao, Tatsuda, Daisuke, Ohba, Shun‐ichi, Masuda, Tohru, Ikeda, Daishiro, Nomoto, Akio

“…A proteasome degrades numerous regulatory proteins that are critical for tumor growth and is therefore recognized as a promising anticancer target. Determining…”
Get full text

Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2 by Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Hatano, Masaki, Amemiya, Masahide, Hayashi, Chigusa, Usami, Ihomi, Abe, Hikaru, Watanabe, Takumi, Kinoshita, Naoko, Igarashi, Masayuki, Masuda, Tohru, Ikeda, Daishiro, Nomoto, Akio

“…Because stromal cells can regulate the growth and metastasis of tumor cells, a compound that modulates the interaction between the stromal cells and the tumor…”
Get full text