Search Results - "Ohba, Hiroyuki"

4D deep image prior: dynamic PET image denoising using an unsupervised four-dimensional branch convolutional neural network by Hashimoto, Fumio, Ohba, Hiroyuki, Ote, Kibo, Kakimoto, Akihiro, Tsukada, Hideo, Ouchi, Yasuomi

“…Although convolutional neural networks (CNNs) demonstrate the superior performance in denoising positron emission tomography (PET) images, a supervised…”
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Dynamic PET Image Denoising Using Deep Convolutional Neural Networks Without Prior Training Datasets by Hashimoto, Fumio, Ohba, Hiroyuki, Ote, Kibo, Teramoto, Atsushi, Tsukada, Hideo

“…Deep learning has attracted growing interest for application to medical imaging, such as positron emission tomography (PET), due to its excellent performance…”
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Imaging mitochondrial complex I activation during a vibrotactile stimulation: A PET study using [18F]BCPP-EF in the conscious monkey brain by Fang, Jingwan, Ohba, Hiroyuki, Hashimoto, Fumio, Tsukada, Hideo, Chen, Feiyan, Liu, Huafeng

“…In order to evaluate the capability of 2-tert-butyl-4-chloro-5-{6-[2-(2-[18F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one ([18F]BCPP-EF), a…”
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Animal PET scanner with a large field of view is suitable for high-throughput scanning of rodents by Tomonari, Yuki, Onishi, Yuya, Hashimoto, Fumio, Ote, Kibo, Okamoto, Takashi, Ohba, Hiroyuki

“…Objective In preclinical studies, high-throughput positron emission tomography (PET) imaging, known as simultaneous multiple animal scanning, can reduce the…”
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Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function by García-Varela, Lara, Vállez García, David, Aguiar, Pablo, Kakiuchi, Takeharu, Ohba, Hiroyuki, Harada, Norihiro, Nishiyama, Shingo, Tago, Tetsuro, Elsinga, Philip H., Tsukada, Hideo, Colabufo, Nicola A., Dierckx, Rudi A. J. O., van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert

“…Purpose P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of interest to monitor the P-gp function in vivo using PET. ( R )-[…”
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Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys by YAMAMOTO, Shigeyuki, OHBA, Hiroyuki, NISHIYAMA, Shingo, HARADA, Norihiro, KAKIUCHI, Takeharu, TSUKADA, Hideo, DOMINO, Edward F

“…Subanesthetic doses of ketamine, an N-methyl-D-aspartic acid (NMDA) antagonist, have a rapid antidepressant effect which lasts for up to 2 weeks. However, the…”
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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study by Yamagishi, Satoru, Iga, Yurika, Nakamura, Masato, Takizawa, Chika, Fukumoto, Dai, Kakiuchi, Takeharu, Nishiyama, Shingo, Ohba, Hiroyuki, Tsukada, Hideo, Sato, Kohji, Ouchi, Yasuomi

“…Microglial cells are activated in response to changes in brain homeostasis during aging, dementia, and stroke. Type 2 endocannabinoid receptors (CB2) and…”
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PET Imaging of Ischemia-Induced Impairment of Mitochondrial Complex I Function in Monkey Brain by Tsukada, Hideo, Ohba, Hiroyuki, Nishiyama, Shingo, Kanazawa, Masakatsu, Kakiuchi, Takeharu, Harada, Norihiro

“…To assess the capability of 18F-2-tert-butyl-4-chloro-5-{6-[2-(2-fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one (18F-BCPP-EF), a novel positron…”
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In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study by Hosoya, Teruyo, Fukumoto, Dai, Kakiuchi, Takeharu, Nishiyama, Shingo, Yamamoto, Shigeyuki, Ohba, Hiroyuki, Tsukada, Hideo, Ueki, Takatoshi, Sato, Kohji, Ouchi, Yasuomi

“…Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of…”
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In vivo alterations of mitochondrial activity and amyloidosis in early-stage senescence-accelerated mice: a positron emission tomography study by Yamagishi, Satoru, Iga, Yurika, Ikegaya, Shunsuke, Kakiuchi, Takeharu, Ohba, Hiroyuki, Nishiyama, Shingo, Fukomoto, Daisuke, Kanazawa, Masakatsu, Harada, Norihiro, Tsukada, Hideo, Sato, Kohji, Ouchi, Yasuomi

“…While marked reductions in neural activity and mitochondrial function have been reported in Alzheimer's disease (AD), the degree of mitochondrial activity in…”
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Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity by Hosoi, Rie, Fujii, Yuka, Hiroyuki, Ohba, Shukuri, Miho, Nishiyama, Shingo, Kanazawa, Masakatsu, Todoroki, Kenichiro, Arano, Yasushi, Sakai, Toshihiro, Tsukada, Hideo, Inoue, Osamu

“…Purpose Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative…”
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Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography by Mitsui, Katsukuni, Morimoto, Noriko, Niwa, Tomohiro, Yamaura, Yoshiyuki, Ohba, Hiroyuki, Tsukada, Hideo, Katsumata, Seishi

“…We have previously shown that ONO-2952, a novel 18-kDa translocator protein (TSPO) antagonist, inhibits stress-induced accumulation of neurosteroids and…”
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Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide by Hata, Saori, Saito, Haruka, Kakiuchi, Takeharu, Fukumoto, Dai, Yamamoto, Shigeyuki, Kasuga, Kensaku, Kimura, Ayano, Moteki, Koichi, Abe, Ruriko, Adachi, Shungo, Kinoshita, Shoich, Yoshizawa‐Kumagaye, Kumiko, Nishio, Hideki, Saito, Takashi, Saido, Takaomi C, Yamamoto, Tohru, Nishimura, Masaki, Taru, Hidenori, Sobu, Yuriko, Ohba, Hiroyuki, Nishiyama, Shingo, Harada, Norihiro, Ikeuchi, Takeshi, Tsukada, Hideo, Ouchi, Yasuomi, Suzuki, Toshiharu

“…We propose a new therapeutic strategy for Alzheimer's disease (AD). Brain peptide p3‐Alcβ37 is generated from the neuronal protein alcadein β through cleavage…”
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Pharmacokinetic Modeling of ( R )-[ 11 C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates by García-Varela, Lara, García, David Vállez, Kakiuchi, Takeharu, Ohba, Hiroyuki, Nishiyama, Shingo, Tago, Tetsuro, Elsinga, Philip H, Tsukada, Hideo, Colabufo, Nicola A, Dierckx, Rudi A J O, van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert

“…( )-[ C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Several studies have…”
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Synthesis of 6-[11C]methyl-m-tyrosine ([11C]6MemTyr) for dopamine synthesis imaging in living brain using PET by Kanazawa, Masakatsu, Ohba, Hiroyuki, Iwazaki, Aiko, Kakiuchi, Takeharu, Tsukada, Hideo

“…[Display omitted] A novel PET probe, 6-[11C]methyl-m-tyrosine ([11C]6MemTyr), was developed for quantitative imaging of presynaptic dopamine (DA) synthesis in…”
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Synthesis and evaluation of N-isopropyl-p-[11C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography by Toyohara, Jun, Harada, Norihiro, Kakiuchi, Takeharu, Ohba, Hiroyuki, Kanazawa, Masakatsu, Tago, Tetsuro, Sakata, Muneyuki, Ishiwata, Kiichi

“…Introduction Increases in fasting plasma glucose (PG) levels lead to a decrease in 2-deoxy-2-[ 18 F]fluoro- d -glucose ([ 18 F]FDG) uptake in the normal brain,…”
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Effect of Oxygen Affinity of Liposome‐Encapsulated Hemoglobin on Cerebral Ischemia and Reperfusion as Detected by Positron Emission Tomography in Nonhuman Primates by Kawaguchi, Akira T., Yamano, Mariko, Haida, Munetaka, Ohba, Hiroyuki, Kakiuchi, Takeharu, Tsukada, Hideo

“…We tested a hypothesis that liposome‐encapsulated hemoglobin (LEH) with high oxygen (O2) affinity (h‐LEH, P50O2 = 10 mm Hg) may work better than LEH with low…”
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Differential effects of stress on [11C]raclopride and [11C]MNPA binding to striatal D2/D3 dopamine receptors: A PET study in conscious monkeys by Tsukada, Hideo, Ohba, Hiroyuki, Nishiyama, Shingo, Kakiuchi, Takeharu

“…It has been reported that stress and facilitation of dopamine neuronal system are closely related. In the present study, the effects of stress on the binding…”
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[11C]CHIBA-1001 as a Novel PET Ligand for α7 Nicotinic Receptors in the Brain: A PET Study in Conscious Monkeys by Hashimoto, Kenji, Nishiyama, Shingo, Ohba, Hiroyuki, Matsuo, Masaaki, Kobashi, Tatsuhiko, Takahagi, Makoto, Iyo, Masaomi, Kitashoji, Takeru, Tsukada, Hideo

“…Background The α7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia…”
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In Vivo Evaluation of 11C-Preladenant for PET Imaging of Adenosine A2A Receptors in the Conscious Monkey by Zhou, Xiaoyun, Boellaard, Ronald, Ishiwata, Kiichi, Sakata, Muneyuki, Dierckx, Rudi A J O, de Jong, Johan R, Nishiyama, Shingo, Ohba, Hiroyuki, Tsukada, Hideo, de Vries, Erik F J, Elsinga, Philip H

“…11C-preladenant was developed as a novel PET ligand for the adenosine A2A receptors (A2ARs). The present study aimed to evaluate the suitability of…”
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