Search Results - "Ohayon, Renee"
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Targeting of the Dual Oxidase 2 N-terminal Region to the Plasma Membrane
Published in The Journal of biological chemistry (16-07-2004)“…Dual oxidase 2 (Duox2) is a cell surface glycoprotein that probably provides thyroperoxidase with the H 2 O 2 required to catalyze thyroid hormone synthesis…”
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Biochemical characterization of a Ca/NAD(P)H-dependent H2O2 generator in human thyroid tissue
Published in Biochimie (01-04-1999)“…An NAD(P)H-dependent H2O2 forming activity has been evidenced in thyroid tissue from patients with Grave's disease. Its biochemical properties were compared to…”
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Dual oxidase2 is expressed all along the digestive tract
Published in American journal of physiology: Gastrointestinal and liver physiology (01-05-2005)“…The dual oxidase (Duox)2 flavoprotein is strongly expressed in the thyroid gland, where it plays a critical role in the synthesis of thyroid hormones by…”
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Effect of Iodide on Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity and Duox2 Protein Expression in Isolated Porcine Thyroid Follicles
Published in Endocrinology (Philadelphia) (01-04-2003)“…Thyroperoxidase requires H2O2 to catalyze the biosynthesis of thyroxine residues on thyroglobulin. Iodide inhibits the generation of H2O2, and consequently the…”
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Identification of a Truncated Dual Oxidase 2 (DUOX2) Messenger Ribonucleic Acid (mRNA) in Two Rat Thyroid Cell Lines. Insulin and Forskolin Regulation of DUOX2 mRNA Levels in FRTL-5 Cells and Porcine Thyrocytes
Published in Endocrinology (Philadelphia) (01-02-2003)“…The Duox2 flavoprotein is strongly expressed in the thyroid gland, where it plays a critical role in the synthesis of thyroid hormones likely by providing…”
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Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site
Published in The FASEB journal (01-10-2004)Get full text
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Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase
Published in The Journal of biological chemistry (01-12-1999)“…Hydrogen peroxide is the final electron acceptor for the biosynthesis of thyroid hormone catalyzed by thyroperoxidase at the apical surface of thyrocytes. Pig…”
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Dual Oxidase-2 Has an Intrinsic Ca super(2+)-dependent H sub(2)O sub(2)-generating Activity
Published in The Journal of biological chemistry (01-08-2005)“…Duox2 (and probably Duox1) is a glycoflavoprotein involved in thyroid hormone biosynthesis, as the thyroid H sub(2)O sub(2) generator functionally associated…”
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Inhibition of thyroid NADPH-oxidase by 2-iodohexadecanal in a cell-free system
Published in Molecular and cellular endocrinology (01-02-1994)“…The major nonpolar iodolipid formed in horse thyroid cells has recently been identified as 2-iodohexadecanal (2-IHDA). We have investigated in vitro the effect…”
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Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas
Published in The Journal of biological chemistry (24-12-1999)“…Hydrogen peroxide is the final electron acceptor for the biosynthesis of thyroid hormone catalyzed by thyroperoxidase at the apical surface of thyrocytes. Pig…”
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Dual Oxidase-2 Has an Intrinsic Ca2+-dependent H2O2-generating Activity
Published in The Journal of biological chemistry (26-08-2005)“…Duox2 (and probably Duox1) is a glycoflavoprotein involved in thyroid hormone biosynthesis, as the thyroid H2O2 generator functionally associated with Tpo…”
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Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site
Published in The FASEB journal (01-10-2004)“…ABSTRACT In the thyroid, iodotyrosine dehalogenase acts on the mono and diiodotyrosines released during the hydrolysis of thyroglobulin to liberate iodide,…”
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Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues
Published in The journal of clinical endocrinology and metabolism (01-07-2001)“…The large homolog of NADPH oxidase flavoprotein LNOX2, and probably LNOX1, are flavoproteins involved in the thyroid H(2)O(2) generator. Western blot analysis…”
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Cloning and characterization of a novel isoform of iodotyrosine dehalogenase 1 (DEHAL1) DEHAL1C from human thyroid: comparisons with DEHAL1 and DEHAL1B
Published in Thyroid (New York, N.Y.) (01-08-2006)“…The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published in GenBank, both of which…”
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Thyroid Oxidase (THOX2) Gene Expression in the Rat Thyroid Cell Line FRTL-5
Published in Biochemical and biophysical research communications (22-10-2000)“…A cDNA encoding an NADPH oxidase flavoprotein was isolated from the rat thyroid gland. The predicted 1517-residue polypeptide was 82.5% identical to the human…”
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Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue
Published in Biochimie (01-04-1999)“…An NAD(P)H-dependent H2O2 forming activity has been evidenced in thyroid tissue from patients with Grave's disease. Its biochemical properties were compared to…”
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Thyroidal cAMP-dependent protein kinases. Particular of the type I kinase, and compartmentalization of the two isoenzymes
Published in European journal of biochemistry (01-07-1982)“…Thyroidal cyclic-AMP-dependent protein kinases, present in two subcellular compartments (cytosol and particulate fraction), were characterized using several…”
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Expression of Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase (ThoX, LNOX, Duox) Genes and Proteins in Human Thyroid Tissues1
Published in The journal of clinical endocrinology and metabolism (01-07-2001)“…The large homolog of NADPH oxidase flavoprotein LNOX2, and probably LNOX1, are flavoproteins involved in the thyroid H2O2 generator. Western blot analysis of…”
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Regulation of the thyroid NADPH-dependent H2O2 generator by Ca2+: studies with phenylarsine oxide in thyroid plasma membrane
Published in Biochemical journal (15-01-1997)“…Pig thyroid plasma membranes contain a Ca(2+)-dependent NADPH:O2 oxidoreductase, the thyroid NADPH-dependent H2O2 generator. This provided the H2O2 for the…”
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