Search Results - "Ohashi, Yoshifumi"

Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis by Ohashi, Yoshifumi, Takahashi, Nobunori, Terabe, Kenya, Tsuchiya, Saho, Kojima, Toshihisa, Knudson, Cheryl B., Knudson, Warren, Imagama, Shiro

“…Metabolic dysfunction in chondrocytes drives the pro-catabolic phenotype associated with osteoarthritic cartilage. In this study, substitution of galactose for…”
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Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism by Terabe, Kenya, Ohashi, Yoshifumi, Tsuchiya, Saho, Ishizuka, Shinya, Knudson, Cheryl B., Knudson, Warren

“…Hyaluronan is a critical component of articular cartilage and partially helps retain aggrecan within the extracellular matrix of this tissue. During…”
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Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway by Hattori, Kyosuke, Takahashi, Nobunori, Terabe, Kenya, Ohashi, Yoshifumi, Kishimoto, Kenji, Yokota, Yutaka, Suzuki, Mochihito, Kojima, Toshihisa, Imagama, Shiro

“…Transient receptor potential vanilloid 4 (TRPV4) plays an important role in chondrocytes via Ca 2+ signaling. However, its role in the progression of…”
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Metabolic changes in synovial cells in early inflammation: Involvement of CREB phosphorylation in the anti-inflammatory effect of 2-deoxyglucose by Kishimoto, Kenji, Terabe, Kenya, Takahashi, Nobunori, Yokota, Yutaka, Ohashi, Yoshifumi, Hattori, Kyosuke, Kihira, Daisuke, Maeda, Masataka, Kojima, Toshihisa, Imagama, Shiro

“…The involvement of metabolic reprogramming has been suggested to contribute to the pathophysiology of rheumatoid arthritis (RA). Glycolysis is enhanced in…”
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Hyaluronan synthase 2 (HAS2) overexpression diminishes the procatabolic activity of chondrocytes by a mechanism independent of extracellular hyaluronan by Ishizuka, Shinya, Tsuchiya, Saho, Ohashi, Yoshifumi, Terabe, Kenya, Askew, Emily B., Ishizuka, Naoko, Knudson, Cheryl B., Knudson, Warren

“…Osteoarthritis (OA) is a progressive degenerative disease of the joints caused in part by a change in the phenotype of resident chondrocytes within affected…”
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Validation of grip strength as a measure of frailty in rheumatoid arthritis by Sobue, Yasumori, Suzuki, Mochihito, Ohashi, Yoshifumi, Koshima, Hiroshi, Okui, Nobuyuki, Funahashi, Koji, Ishikawa, Hisato, Inoue, Hidenori, Kojima, Masayo, Asai, Shuji, Terabe, Kenya, Kishimoto, Kenji, Maeda, Masataka, Kihira, Daisuke, Imagama, Shiro, Kojima, Toshihisa

“…Rheumatoid arthritis (RA) patients often exhibit finger/wrist joint symptoms and reduced grip strength. This study aimed to validate grip strength as a measure…”
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Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage by Sobue, Yasumori, Suzuki, Mochihito, Ohashi, Yoshifumi, Koshima, Hiroshi, Okui, Nobuyuki, Funahashi, Koji, Ishikawa, Hisato, Asai, Shuji, Terabe, Kenya, Yokota, Yutaka, Kishimoto, Kenji, Takahashi, Nobunori, Imagama, Shiro, Kojima, Toshihisa

“…This study aimed to evaluate the association between locomotive syndrome (LS) and frailty in rheumatoid arthritis (RA) patients. Subjects were 538 RA patients…”
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Suppression of murine osteoarthritis by 4‐methylumbelliferone by Tsuchiya, Saho, Ohashi, Yoshifumi, Ishizuka, Shinya, Ishiguro, Naoki, O'Rourke, Dorcas P., Knudson, Cheryl B., Knudson, Warren

“…ABSTRACT Using in vitro models, we previously reported that 4‐methylumbelliferone (4‐MU) blocked many of the pro‐catabolic features of activated chondrocytes…”
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Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells by Suzuki, Mochihito, Takahashi, Nobunori, Sobue, Yasumori, Ohashi, Yoshifumi, Kishimoto, Kenji, Hattori, Kyosuke, Ishiguro, Naoki, Kojima, Toshihisa

“…Cathepsin K is a protease known to be involved in not only bone remodeling and resorption, but also articular cartilage degradation that leads to…”
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Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study by Sobue, Yasumori, Kojima, Toshihisa, Funahashi, Koji, Okui, Nobuyuki, Takahashi, Nobunori, Asai, Shuji, Terabe, Kenya, Nishiume, Tsuyoshi, Suzuki, Mochihito, Yokota, Yutaka, Ohashi, Yoshifumi, Ishiguro, Naoki

“…This study aimed to longitudinally evaluate the association between rheumatoid arthritis (RA) and locomotive syndrome (LS) in RA patients using the 25-question…”
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Influence of frailty on patient global assessment in rheumatoid arthritis by Suzuki, Mochihito, Asai, Shuji, Sobue, Yasumori, Ohashi, Yoshifumi, Koshima, Hiroshi, Okui, Nobuyuki, Ishikawa, Hisato, Takahashi, Nobunori, Terabe, Kenya, Kishimoto, Kenji, Hattori, Kyosuke, Imagama, Shiro, Kojima, Toshihisa

“…Aim Patient Global Assessment (PtGA; range 0–10 cm) is an important indicator of clinical outcomes, including physical function, in self‐assessment of patients…”
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Association between heated tobacco product use and airway obstruction: a single-centre observational study, Japan by Odani, Satomi, Koyama, Shihoko, Miyashiro, Isao, Tanigami, Hironobu, Ohashi, Yoshifumi, Tabuchi, Takahiro

“…BackgroundWhile heated tobacco products (HTPs) may affect pulmonary function, the evidence supporting the utility of screening for HTP use in clinical settings…”
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Inhibition of CD44 intracellular domain production suppresses bovine articular chondrocyte de-differentiation induced by excessive mechanical stress loading by Sobue, Yasumori, Takahashi, Nobunori, Ohashi, Yoshifumi, Suzuki, Mochihito, Nishiume, Tsuyoshi, Kobayakawa, Tomonori, Terabe, Kenya, Knudson, Warren, Knudson, Cheryl, Ishiguro, Naoki, Kojima, Toshihisa

“…CD44 fragmentation is enhanced in chondrocytes of osteoarthritis (OA) patients. We hypothesized that mechanical stress-induced enhancement of…”
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Factors associated with frailty in rheumatoid arthritis patients with decreased renal function by Ohashi, Yoshifumi, Takahashi, Nobunori, Sobue, Yasumori, Suzuki, Mochihito, Hattori, Kyosuke, Kishimoto, Kenji, Terabe, Kenya, Asai, Shuji, Kojima, Toshihisa, Kojima, Masayo, Imagama, Shiro

“…ABSTRACT Objectives To investigate factors associated with frailty in rheumatoid arthritis (RA) patients with decreased renal function. Methods RA patients who…”
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Effectiveness of tacrolimus concomitant with biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis by Terabe, Kenya, Takahashi, Nobunori, Asai, Shuji, Hirano, Yuji, Kanayama, Yasuhide, Yabe, Yuichiro, Oguchi, Takeshi, Fujibayashi, Takayoshi, Ishikawa, Hisato, Hanabayashi, Masahiro, Hattori, Yosuke, Suzuki, Mochihito, Kishimoto, Kenji, Ohashi, Yoshifumi, Imaizumi, Takahiro, Imagama, Shiro, Kojima, Toshihisa

“…ABSTRACT Objectives The study aimed to investigate the effectiveness and tolerance of biological disease-modifying antirheumatic drugs (bDMARDs) therapy…”
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Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic by Sobue, Yasumori, Suzuki, Mochihito, Ohashi, Yoshifumi, Koshima, Hiroshi, Okui, Nobuyuki, Funahashi, Koji, Ishikawa, Hisato, Inoue, Hidenori, Kojima, Masayo, Asai, Shuji, Terabe, Kenya, Hattori, Kyosuke, Kishimoto, Kenji, Takahashi, Nobunori, Imagama, Shiro, Kojima, Toshihisa

“…This study aimed to longitudinally evaluate the development of locomotive syndrome (LS) in rheumatoid arthritis (RA) patients during the COVID-19 pandemic…”
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Association between locomotive syndrome and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients: A retrospective observational study by Sobue, Yasumori, Suzuki, Mochihito, Ohashi, Yoshifumi, Koshima, Hiroshi, Okui, Nobuyuki, Funahashi, Koji, Ishikawa, Hisato, Inoue, Hidenori, Kojima, Masayo, Asai, Shuji, Terabe, Kenya, Hattori, Kyosuke, Kishimoto, Kenji, Takahashi, Nobunori, Imagama, Shiro, Kojima, Toshihisa

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Verification of grip strength as an evaluation tool for locomotive syndrome in rheumatoid arthritis by Sobue, Yasumori, Suzuki, Mochihito, Ohashi, Yoshifumi, Sato, Ryo, Kosugiyama, Hironobu, Ohno, Yusuke, Hasegawa, Junya, Sugiura, Takaya, Terabe, Kenya, Asai, Shuji, Imagama, Shiro

“…Locomotive syndrome (LS) leads to reduced physical function and a high risk of becoming bedridden. Grip strength serves as an indicator of upper limb and…”
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Ketamine Inhibits Maturation of Bone Marrow-Derived Dendritic Cells and Priming of the Th1-Type Immune Response by Ohta, Noriyuki, Ohashi, Yoshifumi, Fujino, Yuji

“…Dendritic cells (DCs) play a key role as antigen-presenting cells and growing evidence suggests that DCs influence T-cell activation and regulate the polarity…”
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Periprosthetic humeral fracture revision using a massive allograft in a patient with rheumatoid arthritis: A case report by Kishimoto, Kenji, Kojima, Toshihisa, Takahashi, Nobunori, Asai, Shuji, Terabe, Kenya, Suzuki, Mochihito, Ohashi, Yoshifumi, Kihira, Daisuke, Maeda, Masataka, Tatebe, Masahiro, Imagama, Shiro

“…ABSTRACT Total elbow arthroplasty (TEA) is a surgical option for patients with rheumatoid arthritis (RA). Periprosthetic fractures during and after TEA are one…”
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