Search Results - "Ohashi, Yohei"

Activation Mechanisms of the VPS34 Complexes by Ohashi, Yohei

“…Phosphatidylinositol-3-phosphate (PtdIns(3)P) is essential for cell survival, and its intracellular synthesis is spatially and temporally regulated. It has…”
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Membrane delivery to the yeast autophagosome from the Golgi-endosomal system by Ohashi, Yohei, Munro, Sean

“…While many of the proteins required for autophagy have been identified, the source of the membrane of the autophagosome is still unresolved with the…”
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VPS34 complexes from a structural perspective by Ohashi, Yohei, Tremel, Shirley, Williams, Roger L.

“…VPS34 phosphorylates phosphatidylinositol to produce PtdIns3P and is the progenitor of the phosphoinositide 3-kinase (PI3K) family. VPS34 has a simpler domain…”
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Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes by Tremel, Shirley, Ohashi, Yohei, Morado, Dustin R., Bertram, Jessie, Perisic, Olga, Brandt, Laura T. L., von Wrisberg, Marie-Kristin, Chen, Zhuo A., Maslen, Sarah L., Kovtun, Oleksiy, Skehel, Mark, Rappsilber, Juri, Lang, Kathrin, Munro, Sean, Briggs, John A. G., Williams, Roger L.

“…The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its…”
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Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes by Rostislavleva, Ksenia, Soler, Nicolas, Ohashi, Yohei, Zhang, Lufei, Pardon, Els, Burke, John E., Masson, Glenn R., Johnson, Chris, Steyaert, Jan, Ktistakis, Nicholas T., Williams, Roger L.

“…Phosphatidylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting, cytokinesis, and autophagy. We present the 4.4…”
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Arabidopsis PLDζ1 and PLDζ2 localize to post-Golgi membrane compartments in a partially overlapping manner by Shimamura, Ryota, Ohashi, Yohei, Taniguchi, Yukimi Yamamoto, Kato, Mariko, Tsuge, Tomohiko, Aoyama, Takashi

“…Key message Arabidopsis PLDζ1 and PLDζ2 localize to the trans -Golgi network and to compartments including the trans -Golgi network, multi-vesicular bodies,…”
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Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes by Ohashi, Yohei, Tremel, Shirley, Masson, Glenn Robert, McGinney, Lauren, Boulanger, Jerome, Rostislavleva, Ksenia, Johnson, Christopher M, Niewczas, Izabella, Clark, Jonathan, Williams, Roger L

“…The lipid kinase VPS34 orchestrates diverse processes, including autophagy, endocytic sorting, phagocytosis, anabolic responses and cell division. VPS34 forms…”
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Tor forms a dimer through an N-terminal helical solenoid with a complex topology by Baretić, Domagoj, Berndt, Alex, Ohashi, Yohei, Johnson, Christopher M., Williams, Roger L.

“…The target of rapamycin (Tor) is a Ser/Thr protein kinase that regulates a range of anabolic and catabolic processes. Tor is present in two complexes, TORC1…”
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Impact on visual acuity and psychological outcomes of ranibizumab and subsequent treatment for diabetic macular oedema in Japan (MERCURY) by Sakamoto, Taiji, Shimura, Masahiko, Kitano, Shigehiko, Ohji, Masahito, Ogura, Yuichiro, Yamashita, Hidetoshi, Suzaki, Makoto, Mori, Kimie, Ohashi, Yohei, Yap, Poh Sin, Kaneko, Takeumi, Ishibashi, Tatsuro

“…Purpose The MERCURY study aimed to evaluate the effects on visual acuity and psychological symptoms, and safety, of ranibizumab and subsequent treatment in…”
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The randomized ZIPANGU trial of ranibizumab and adjunct laser for macular edema following branch retinal vein occlusion in treatment-naïve patients by Murata, Toshinori, Kondo, Mineo, Inoue, Makoto, Nakao, Shintaro, Osaka, Rie, Shiragami, Chieko, Sogawa, Kenji, Mochizuki, Akikazu, Shiraga, Rumiko, Ohashi, Yohei, Kaneko, Takeumi, Chandrasekhar, Chikatapu, Tsujikawa, Akitaka, Kamei, Motohiro

“…The ZIPANGU study assessed the efficacy and safety of ranibizumab as a one loading dose +  pro re nata (one + PRN) regimen with/without focal/grid laser among…”
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Author Correction: The randomized ZIPANGU trial of ranibizumab and adjunct laser for macular edema following branch retinal vein occlusion in treatment‑naïve patients by Murata, Toshinori, Kondo, Mineo, Inoue, Makoto, Nakao, Shintaro, Osaka, Rie, Shiragami, Chieko, Sogawa, Kenji, Mochizuki, Akikazu, Shiraga, Rumiko, Ohashi, Yohei, Kaneko, Takeumi, Chandrasekhar, Chikatapu, Tsujikawa, Akitaka, Kamei, Motohiro

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Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex by Ohashi, Yohei, Soler, Nicolas, García Ortegón, Miguel, Zhang, Lufei, Kirsten, Marie L., Perisic, Olga, Masson, Glenn R., Burke, John E., Jakobi, Arjen J., Apostolakis, Apostolos A., Johnson, Christopher M., Ohashi, Maki, Ktistakis, Nicholas T., Sachse, Carsten, Williams, Roger L.

“…The phosphatidylinositol 3-kinase Vps34 is part of several protein complexes. The structural organization of heterotetrameric complexes is starting to emerge,…”
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A glass-coated tungsten microelectrode enclosing optical fibers for optogenetic exploration in primate deep brain structures by Tamura, Keita, Ohashi, Yohei, Tsubota, Tadashi, Takeuchi, Daigo, Hirabayashi, Toshiyuki, Yaguchi, Masae, Matsuyama, Makoto, Sekine, Takeru, Miyashita, Yasushi

“…[Display omitted] ► We have developed a glass-coated tungsten optrode enclosing optical fibers. ► The optrode was sharp and smooth to reduce tissue damage…”
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Real-world outcomes of the Xarelto Post-Authorization Safety & Effectiveness Study in Japanese Patients with Atrial Fibrillation (XAPASS) by Ikeda, Takanori, Ogawa, Satoshi, Kitazono, Takanari, Nakagawara, Jyoji, Minematsu, Kazuo, Miyamoto, Susumu, Murakawa, Yuji, Takeichi, Makiko, Ohashi, Yohei, Okayama, Yutaka, Sunaya, Toshiyuki, Yamanaka, Satoshi

“…•Non-valvular atrial fibrillation patients newly prescribed rivaroxaban for stroke/systemic embolism prevention were included.•The 1-year outcomes of the…”
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Optogenetics in the cerebellum: Purkinje cell-specific approaches for understanding local cerebellar functions by Tsubota, Tadashi, Ohashi, Yohei, Tamura, Keita

“…•The cerebellar cortex is subdivided by anatomical and genetic characteristics.•Functional differences among these subdivisions are not fully…”
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Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells by Tabuse, Masanao, Ohta, Shigeki, Ohashi, Yohei, Fukaya, Raita, Misawa, Aya, Yoshida, Kazunari, Kawase, Takeshi, Saya, Hideyuki, Thirant, Cécile, Chneiweiss, Hérve, Matsuzaki, Yumi, Okano, Hideyuki, Kawakami, Yutaka, Toda, Masahiro

“…HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development…”
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Optogenetic manipulation of cerebellar Purkinje cell activity in vivo by Tsubota, Tadashi, Ohashi, Yohei, Tamura, Keita, Sato, Ayana, Miyashita, Yasushi

“…Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex. Although their anatomical connections and physiological response properties have…”
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Point-of-Care Device for Warfarin Monitoring Used in the J-ROCKET AF Study by On behalf of the J-ROCKET AF Study Investigators, Hori, Masatsugu, Ohashi, Yohei, Pan, Guohua, Kato, Masaharu, Kajikawa, Mariko

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Avian sarcoma leukosis virus receptor-envelope system for simultaneous dissection of multiple neural circuits in mammalian brain by Matsuyama, Makoto, Ohashi, Yohei, Tsubota, Tadashi, Yaguchi, Masae, Kato, Shigeki, Kobayashi, Kazuto, Miyashita, Yasushi

“…Pathway-specific gene delivery is requisite for understanding complex neuronal systems in which neurons that project to different target regions are locally…”
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Modulation of Phospholipid Signaling by GLABRA2 in Root-Hair Pattern Formation by Ohashi, Yohei, Oka, Atsuhiro, Rodrigues-Pousada, Renato, Possenti, Marco, Ruberti, Ida, Morelli, Giorgio, Aoyama, Takashi

“…The root-hair pattern of Arabidopsis is determined through a regulatory circuit composed of transcription factor genes. The homeobox gene GLABRA2 (GL2) has…”
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