Search Results - "Ohara Osamu"

Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis by Kawashima, Yusuke, Watanabe, Eiichiro, Umeyama, Taichi, Nakajima, Daisuke, Hattori, Masahira, Honda, Kenya, Ohara, Osamu

“…Data-independent acquisition (DIA)-mass spectrometry (MS)-based proteomic analysis overtop the existing data-dependent acquisition (DDA)-MS-based proteomic…”
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Toward proteome‐wide exploration of proteins in dried blood spots using liquid chromatography‐coupled mass spectrometry by Nakajima, Daisuke, Ohara, Osamu, Kawashima, Yusuke

“…Dried blood spot (DBS) sampling is a method with advantages over conventional blood sampling in relation to collection, cost, storage, and transportation. Such…”
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Acetate differentially regulates IgA reactivity to commensal bacteria by Takeuchi, Tadashi, Miyauchi, Eiji, Kanaya, Takashi, Kato, Tamotsu, Nakanishi, Yumiko, Watanabe, Takashi, Kitami, Toshimori, Taida, Takashi, Sasaki, Takaharu, Negishi, Hiroki, Shimamoto, Shu, Matsuyama, Akinobu, Kimura, Ikuo, Williams, Ifor R., Ohara, Osamu, Ohno, Hiroshi

“…The balance between bacterial colonization and its containment in the intestine is indispensable for the symbiotic relationship between humans and their…”
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Cysteinyl leukotriene metabolism of human eosinophils in allergic disease by Miyata, Jun, Fukunaga, Koichi, Kawashima, Yusuke, Ohara, Osamu, Arita, Makoto

“…Eosinophils are multifaceted immune cells with diverse functions that enhance allergic inflammation. Cysteinyl leukotrienes (cys-LTs), mainly synthesized in…”
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Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system by Wakiyama, Motoaki, Takimoto, Koji, Ohara, Osamu, Yokoyama, Shigeyuki

“…MicroRNAs (miRNAs) are incorporated into miRNP complexes and regulate protein expression post-transcriptionally through binding to 3'-untranslated regions of…”
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Development of a Simple and Stable NanoESI Spray System Using Suction Wind from the MS Inlet by Kawashima, Yusuke, Ishikawa, Masaki, Konno, Ryo, Nakajima, Daisuke, Ohara, Osamu

“…Improving the reproducibility of proteome analysis systems presents a challenge; therefore, in this study, we developed a new insertion spray ionization…”
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Data-Independent Acquisition Mass Spectrometry-Based Deep Proteome Analysis for Hydrophobic Proteins from Dried Blood Spots Enriched by Sodium Carbonate Precipitation by Nakajima, Daisuke, Ohara, Osamu, Kawashima, Yusuke

“…Dried blood spots (DBS) are widely used for screening molecular profiles, including enzymatic activity. However, hydrophilic proteins present in large amounts…”
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Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation by Motomura, Yasutaka, Morita, Hideaki, Moro, Kazuyo, Nakae, Susumu, Artis, David, Endo, Takaho A., Kuroki, Yoko, Ohara, Osamu, Koyasu, Shigeo, Kubo, Masato

“…Allergic asthma is an inflammatory disease characterized by lung eosinophilia controlled by type 2 cytokines. Cysteine proteases are potent triggers…”
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A cell competition system with one gene expression from a single-copy gene in one cell by Hasegawa, Yoshinori, Nakano, Megumi, Hosouchi, Tsutomu, Watanabe, Takashi, Yamaguchi, Izumi, Nakayama, Manabu, Ohara, Osamu

“…Even with advanced plasmid and viral vectors, attaining copy numbers of multiple genes among different transfected cells is challenging. We achieved one gene…”
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Generation of orthotopically functional salivary gland from embryonic stem cells by Tanaka, Junichi, Ogawa, Miho, Hojo, Hironori, Kawashima, Yusuke, Mabuchi, Yo, Hata, Kenji, Nakamura, Shiro, Yasuhara, Rika, Takamatsu, Koki, Irié, Tarou, Fukada, Toshiyuki, Sakai, Takayoshi, Inoue, Tomio, Nishimura, Riko, Ohara, Osamu, Saito, Ichiro, Ohba, Shinsuke, Tsuji, Takashi, Mishima, Kenji

“…Organoids generated from pluripotent stem cells are used in the development of organ replacement regenerative therapy by recapitulating the process of…”
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Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders by Kadowaki, Tomonori, Ohnishi, Hidenori, Kawamoto, Norio, Hori, Tomohiro, Nishimura, Kenichi, Kobayashi, Chie, Shigemura, Tomonari, Ogata, Shohei, Inoue, Yuzaburo, Kawai, Tomoki, Hiejima, Eitaro, Takagi, Masatoshi, Imai, Kohsuke, Nishikomori, Ryuta, Ito, Shuichi, Heike, Toshio, Ohara, Osamu, Morio, Tomohiro, Fukao, Toshiyuki, Kanegane, Hirokazu

“…[...]the refractory cases in our cohort were treated with anti–TNF-α agents, and it successfully induced the remission. [...]our study demonstrated that HA20…”
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Low-frequency mosaicism in cryopyrin-associated periodic fever syndrome: mosaicism in systemic autoinflammatory diseases by Nishikomori, Ryuta, Izawa, Kazushi, Kambe, Naotomo, Ohara, Osamu, Yasumi, Takahiro

“…Abstract Autoinflammatory disease is an ‘inborn error of immunity’, resulting in systemic inflammation. Cryopyrin-associated periodic syndrome (CAPS) is a…”
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An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer by Karasaki, Takahiro, Nagayama, Kazuhiro, Kuwano, Hideki, Nitadori, Jun-Ichi, Sato, Masaaki, Anraku, Masaki, Hosoi, Akihiro, Matsushita, Hirokazu, Morishita, Yasuyuki, Kashiwabara, Kosuke, Takazawa, Masaki, Ohara, Osamu, Kakimi, Kazuhiro, Nakajima, Jun

“…The interaction of immune cells and cancer cells shapes the immunosuppressive tumor microenvironment. For successful cancer immunotherapy, comprehensive…”
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Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells by Miyauchi, Kosuke, Adachi, Yu, Tonouchi, Keisuke, Yajima, Taiki, Harada, Yasuyo, Fukuyama, Hidehiro, Deno, Senka, Iwakura, Yoichiro, Yoshimura, Akihiko, Hasegawa, Hideki, Yugi, Katsuyuki, Fujii, Shin-ichiro, Ohara, Osamu, Takahashi, Yoshimasa, Kubo, Masato

“…Influenza viruses are a major public health problem. Vaccines are the best available countermeasure to induce effective immunity against infection with…”
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PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes by Endoh, Mitsuhiro, Endo, Takaho A, Shinga, Jun, Hayashi, Katsuhiko, Farcas, Anca, Ma, Kit-Wan, Ito, Shinsuke, Sharif, Jafar, Endoh, Tamie, Onaga, Naoko, Nakayama, Manabu, Ishikura, Tomoyuki, Masui, Osamu, Kessler, Benedikt M, Suda, Toshio, Ohara, Osamu, Okuda, Akihiko, Klose, Robert, Koseki, Haruhiko

“…The ring finger protein PCGF6 (polycomb group ring finger 6) interacts with RING1A/B and E2F6 associated factors to form a non-canonical PRC1 (polycomb…”
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TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia by Ochiiwa, Hiroaki, Ailiken, Guzhanuer, Yokoyama, Masataka, Yamagata, Kazuyuki, Nagano, Hidekazu, Yoshimura, Chihoko, Muraoka, Hiromi, Ishida, Keiji, Haruma, Tomonori, Nakayama, Akitoshi, Hashimoto, Naoko, Murata, Kazutaka, Nishimura, Motoi, Kawashima, Yusuke, Ohara, Osamu, Ohkubo, Shuichi, Tanaka, Tomoaki

“…TAS4464, a potent, selective small molecule NEDD8-activating enzyme (NAE) inhibitor, leads to inactivation of cullin-RING E3 ubiquitin ligases (CRLs) and…”
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PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations by Yamaguchi, Izumi, Watanabe, Takashi, Ohara, Osamu, Hasegawa, Yoshinori

“…In this study, we describe the development of a PCR-free whole exome sequencing method. Using this method, 2 μg DNA was sufficient for library preparation for…”
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Proteome Analysis of Serum Purified Using Solanum tuberosum and Lycopersicon esculentum Lectins by Nakajima, Daisuke, Konno, Ryo, Miyashita, Yasuomi, Ishikawa, Masaki, Ohara, Osamu, Kawashima, Yusuke

“…Serum and plasma exhibit a broad dynamic range of protein concentrations, posing challenges for proteome analysis. Various technologies have been developed to…”
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A novel mucosal vaccine targeting Peyer's patch M cells induces protective antigen-specific IgA responses by Shima, Hideaki, Watanabe, Takashi, Fukuda, Shinji, Fukuoka, Shin-Ichi, Ohara, Osamu, Ohno, Hiroshi

“…Mucosal vaccines can induce mucosal immunity, including antigen-specific secretory IgA production, to protect from invasion by pathogens and to neutralize…”
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Autosomal recessive complete STAT1 deficiency caused by compound heterozygous intronic mutations by Sakata, Sonoko, Tsumura, Miyuki, Matsubayashi, Tadashi, Karakawa, Shuhei, Kimura, Shunsuke, Tamaura, Moe, Okano, Tsubasa, Naruto, Takuya, Mizoguchi, Yoko, Kagawa, Reiko, Nishimura, Shiho, Imai, Kohsuke, Le Voyer, Tom, Casanova, Jean-Laurent, Bustamante, Jacinta, Morio, Tomohiro, Ohara, Osamu, Kobayashi, Masao, Okada, Satoshi

“…Abstract Autosomal recessive (AR) complete signal transducer and activator of transcription 1 (STAT1) deficiency is an extremely rare primary immunodeficiency…”
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