Search Results - "Ohara, Yuuki"

Drug-exposed cancer-associated fibroblasts facilitate gastric cancer cell progression following chemotherapy by Ishii, Takahiro, Suzuki, Ayako, Kuwata, Takeshi, Hisamitsu, Shoshi, Hashimoto, Hiroko, Ohara, Yuuki, Yanagihara, Kazuyoshi, Mitsunaga, Shuichi, Yoshino, Takayuki, Kinoshita, Takahiro, Ochiai, Atsushi, Shitara, Kohei, Ishii, Genichiro

“…Background Cancer progression following chemotherapy is a significant barrier to effective cancer treatment. We aimed to evaluate the role of drug-exposed…”
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Phlebotomy as a preventive measure for crocidolite‐induced mesothelioma in male rats by Ohara, Yuuki, Chew, Shan‐Hwu, Shibata, Takahiro, Okazaki, Yasumasa, Yamashita, Kyoko, Toyokuni, Shinya

“…Malignant mesothelioma (MM) is a rare but socially important neoplasm due to its association with asbestos exposure. Malignant mesothelioma is difficult to…”
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Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner by Sato, Kotaro, Shi, Lei, Ito, Fumiya, Ohara, Yuuki, Motooka, Yashiro, Tanaka, Hiromasa, Mizuno, Masaaki, Hori, Masaru, Hirayama, Tasuku, Hibi, Hideharu, Toyokuni, Shinya

“…Oral cancer accounts for ~2% of all cancers worldwide, and therapeutic intervention is closely associated with quality of life. Here, we evaluated the effects…”
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SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer by Ohara, Yuuki, Tang, Wei, Liu, Huaitian, Yang, Shouhui, Dorsey, Tiffany H., Cawley, Helen, Moreno, Paloma, Chari, Raj, Guest, Mary R., Azizian, Azadeh, Gaedcke, Jochen, Ghadimi, Michael, Hanna, Nader, Ambs, Stefan, Hussain, S. Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) exhibits distinct molecular subtypes: classical/progenitor and basal-like/squamous. Our study aimed to identify genes…”
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Dual preventive benefits of iron elimination by desferal in asbestos‐induced mesothelial carcinogenesis by Jiang, Li, Chew, Shan‐Hwu, Nakamura, Kosuke, Ohara, Yuuki, Akatsuka, Shinya, Toyokuni, Shinya

“…Asbestos‐induced mesothelial carcinogenesis is currently a profound social issue due to its extremely long incubation period and high mortality rate…”
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Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model by Ohara, Yuuki, Chew, Shan Hwu, Misawa, Nobuaki, Wang, Shenqi, Somiya, Daiki, Nakamura, Kae, Kajiyama, Hiroaki, Kikkawa, Fumitaka, Tsuyuki, Yuta, Jiang, Li, Yamashita, Kyoko, Sekido, Yoshitaka, Lipson, Kenneth E, Toyokuni, Shinya

“…Malignant mesothelioma is an aggressive neoplasm with no particularly effective treatments. We previously reported that overexpression of connective tissue…”
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Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification by Yamashita, Kyoko, Kohashi, Kenichi, Yamada, Yuichi, Ishii, Takeaki, Nishida, Yoshihiro, Urakawa, Hiroshi, Ito, Ichiro, Takahashi, Mitsuru, Inoue, Takeshi, Ito, Masafumi, Ohara, Yuuki, Oda, Yoshinao, Toyokuni, Shinya

“…Aims Ossification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is…”
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An autopsy case report: Differences in radiological images correlate with histology in Erdheim–Chester disease by Ohara, Yuuki, Kato, Seiichi, Yamashita, Daisuke, Satou, Akira, Shimoyama, Yoshie, Hamaie, Chie, Sato, Motoki, Ban, Nobutaro, Yamamoto, Koji, Yamada, Takehiro, Kawai, Hisashi, Ohshima, Koichi, Nakamura, Shigeo, Toyokuni, Shinya

“…p16 activation caused by oncogenic mutations may represent oncogene‐induced senescence (OIS), a protective mechanism against oncogenic events. However, OIS can…”
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Acute fulminant invasive pulmonary aspergillosis in an immunocompetent host: An autopsy case report by Ohara, Yuuki, Ito, Takahiko, Ito, Makoto, Yamashita, Kyoko, Toyokuni, Shinya

“…A 62-year-old previously healthy male who was a welder/smoker/drinker was admitted to Kani Tono Hospital for severe hypoxemia (Day 0). Initial physical and…”
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Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments by Kumagai, Shogo, Koyama, Shohei, Itahashi, Kota, Tanegashima, Tokiyoshi, Lin, Yi-tzu, Togashi, Yosuke, Kamada, Takahiro, Irie, Takuma, Okumura, Genki, Kono, Hidetoshi, Ito, Daisuke, Fujii, Rika, Watanabe, Sho, Sai, Atsuo, Fukuoka, Shota, Sugiyama, Eri, Watanabe, Go, Owari, Takuya, Nishinakamura, Hitomi, Sugiyama, Daisuke, Maeda, Yuka, Kawazoe, Akihito, Yukami, Hiroki, Chida, Keigo, Ohara, Yuuki, Yoshida, Tatsuya, Shinno, Yuki, Takeyasu, Yuki, Shirasawa, Masayuki, Nakama, Kenta, Aokage, Keiju, Suzuki, Jun, Ishii, Genichiro, Kuwata, Takeshi, Sakamoto, Naoya, Kawazu, Masahito, Ueno, Toshihide, Mori, Taisuke, Yamazaki, Naoya, Tsuboi, Masahiro, Yatabe, Yasushi, Kinoshita, Takahiro, Doi, Toshihiko, Shitara, Kohei, Mano, Hiroyuki, Nishikawa, Hiroyoshi

“…The balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T (Treg) cells in the tumor microenvironment (TME) determines the clinical…”
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The interactive role of inflammatory mediators and metabolic reprogramming in pancreatic cancer by Ohara, Yuuki, Valenzuela, Paloma, Hussain, S Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by its highly reactive inflammatory desmoplastic stroma with evidence of an extensive tumor stromal…”
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The critical role of CD4+ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma by Nagasaki, Joji, Togashi, Yosuke, Sugawara, Takeaki, Itami, Makiko, Yamauchi, Nobuhiko, Yuda, Junichiro, Sugano, Masato, Ohara, Yuuki, Minami, Yosuke, Nakamae, Hirohisa, Hino, Masayuki, Takeuchi, Masahiro, Nishikawa, Hiroyoshi

“…Classic Hodgkin lymphoma (cHL) responds markedly to PD-1 blockade therapy, and the clinical responses are reportedly dependent on expression of major…”
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LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism by Ohara, Yuuki, Craig, Amanda J, Liu, Huaitian, Yang, Shouhui, Moreno, Paloma, Dorsey, Tiffany H, Cawley, Helen, Azizian, Azadeh, Gaedcke, Jochen, Ghadimi, Michael, Hanna, Nader, Ambs, Stefan, Hussain, S Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) encompasses diverse molecular subtypes, including the classical/progenitor and basal-like/squamous subtypes, each…”
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ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer by Ohara, Yuuki, Liu, Huaitian, Craig, Amanda J, Yang, Shouhui, Moreno, Paloma, Dorsey, Tiffany H, Cawley, Helen, Azizian, Azadeh, Gaedcke, Jochen, Ghadimi, Michael, Hanna, Nader, Ambs, Stefan, Hussain, S Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous…”
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ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer by Moreno, Paloma, Ohara, Yuuki, Craig, Amanda J, Liu, Huaitian, Yang, Shouhui, Dorsey, Tiffany H, Zhang, Lin, Panigrahi, Gatikrushna, Cawley, Helen, Azizian, Azadeh, Gaedcke, Jochen, Ghadimi, Michael, Hanna, Nader, Hussain, S Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) manifests diverse molecular subtypes, including the classical/progenitor and basal-like/squamous subtypes, with the…”
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MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways by Yang, Shouhui, Tang, Wei, Azizian, Azadeh, Gaedcke, Jochen, Ohara, Yuuki, Cawley, Helen, Hanna, Nader, Ghadimi, Michael, Lal, Trisha, Sen, Subrata, Creighton, Chad J, Gao, Jianjun, Putluri, Nagireddy, Ambs, Stefan, Hussain, Perwez

“…Abstract Inflammation and aberrant cellular metabolism are widely recognized as hallmarks of cancer. In pancreatic ductal adenocarcinoma (PDAC), inflammatory…”
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Dysregulation of HNF1B/Clusterin axis enhances disease progression in a highly aggressive subset of pancreatic cancer patients by Yang, Shouhui, Tang, Wei, Azizian, Azadeh, Gaedcke, Jochen, Ströbel, Philipp, Wang, Limin, Cawley, Helen, Ohara, Yuuki, Valenzuela, Paloma, Zhang, Lin, Lal, Trisha, Sinha, Sanju, Rupin, Eythan, Hanna, Nader, Ghadimi, B Michael, Hussain, S Perwez

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is largely refractory to available treatments. Identifying key pathways associated with…”
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291 - Preclinical Use of CTGF-Specific Monoclonal Antibody for the Treatment of Malignant Mesothelioma by Ohara, Yuuki, Wang, Shenqi, Jiang, Li, Toyokuni, Shinya

“…Malignant mesothelioma (MM) is a tumor mostly caused by asbestos exposure. There are several theories of carcinogenesis, including oxidative stress theory…”
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Preclinical Use of CTGF-Specific Monoclonal Antibody for the Treatment of Malignant Mesothelioma by Ohara, Yuuki, Wang, Shenqi, Jiang, Li, Toyokuni, Shinya

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Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma by Ohara, Yuuki, Enomoto, Atsushi, Tsuyuki, Yuta, Sato, Kotaro, Iida, Tadashi, Kobayashi, Hiroki, Mizutani, Yasuyuki, Miyai, Yuki, Hara, Akitoshi, Mii, Shinji, Suzuki, Jun, Yamashita, Kyoko, Ito, Fumiya, Motooka, Yashiro, Misawa, Nobuaki, Fukui, Takayuki, Kawaguchi, Koji, Yokoi, Kohei, Toyokuni, Shinya

“…Malignant mesothelioma is an aggressive neoplasm for which effective treatments are lacking. We often encounter mesothelioma cases with a profound desmoplastic…”
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