Search Results - "Ohara, Makoto"

Relationship between daily and day-to-day glycemic variability and increased oxidative stress in type 2 diabetes by Ohara, Makoto, Fukui, Tomoyasu, Ouchi, Motoshi, Watanabe, Kentaro, Suzuki, Tatsuya, Yamamoto, Saki, Yamamoto, Takeshi, Hayashi, Toshiyuki, Oba, Kenzo, Hirano, Tsutomu

“…Highlights • Day-to-day glucose variability and oxidative stress correlation in T2DM is reported. • Daily and day-to-day glucose variability is associated with…”
Get full text

Glucose-Dependent Insulinotropic Polypeptide Inhibits AGE-Induced NADPH Oxidase-Derived Oxidative Stress Generation and Foam Cell Formation in Macrophages Partly via AMPK Activation by Terasaki, Michishige, Yashima, Hironori, Mori, Yusaku, Saito, Tomomi, Inoue, Naoto, Matsui, Takanori, Osaka, Naoya, Fujikawa, Tomoki, Ohara, Makoto, Yamagishi, Sho-Ichi

“…Glucose-dependent insulinotropic polypeptide (GIP) of the incretin group has been shown to exert pleiotropic actions. There is growing evidence that advanced…”
Get full text

DNA Aptamer Raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing Receptors for Advanced Glycation End Product-Induced Oxidative Stress and Inflammation in the Testes of Diabetic Mice by Mori, Yusaku, Terasaki, Michishige, Osaka, Naoya, Fujikawa, Tomoki, Yashima, Hironori, Saito, Tomomi, Kataoka, Yurie, Ohara, Makoto, Higashimoto, Yuichiro, Matsui, Takanori, Yamagishi, Sho-Ichi

“…Type 2 diabetes mellitus (T2DM) is a risk factor for male infertility, but the underlying molecular mechanisms remain unclear. Advanced glycation end products…”
Get full text

A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression by Terasaki, Michishige, Yashima, Hironori, Mori, Yusaku, Saito, Tomomi, Matsui, Takanori, Hiromura, Munenori, Kushima, Hideki, Osaka, Naoya, Ohara, Makoto, Fukui, Tomoyasu, Hirano, Tsutomu, Yamagishi, Sho-Ichi

“…Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2…”
Get full text

SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis by Terasaki, Michishige, Shibata, Keita, Mori, Yusaku, Saito, Tomomi, Matsui, Takanori, Ohara, Makoto, Fukui, Tomoyasu, Hasumi, Keiji, Higashimoto, Yuichiro, Nobe, Koji, Yamagishi, Sho-Ichi

“…SMTP-44D has been reported to have anti-oxidative and anti-inflammatory reactions, including reduced expression of receptor for advanced glycation end products…”
Get full text

Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling by Mori, Yusaku, Terasaki, Michishige, Hiromura, Munenori, Saito, Tomomi, Kushima, Hideki, Koshibu, Masakazu, Osaka, Naoya, Ohara, Makoto, Fukui, Tomoyasu, Ohtaki, Hirokazu, Tsutomu, Hirano, Yamagishi, Sho-Ichi

“…Excess fat deposition could induce phenotypic changes of perivascular adipose tissue (PVAT remodeling), which may promote the progression of atherosclerosis…”
Get full text

Efficacy of a new enzyme-linked immunosorbent assay system for three islet cell autoantibodies in Japanese patients with acute-onset type 1 diabetes by Fukui, Tomoyasu, Takehana, Nobuaki, Mori, Yusaku, Hiromura, Munenori, Terasaki, Michishige, Kushima, Hideki, Takada, Michiya, Tomoyasu, Masako, Sato, Nobuko, Hayashi, Toshiyuki, Ohara, Makoto, Kikuchi, Tsuyoshi, Ito, Yoshihisa, Kobayashi, Tetsuro, Yamagishi, Sho-ichi

“…To evaluate the clinical efficacy of a new enzyme-linked immunosorbent assay (ELISA) system for simultaneously detecting three islet cell autoantibodies…”
Get full text

AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation by Yashima, Hironori, Terasaki, Michishige, Sotokawauchi, Ami, Matsui, Takanori, Mori, Yusaku, Saito, Tomomi, Osaka, Naoya, Kushima, Hideki, Hiromura, Munenori, Ohara, Makoto, Fukui, Tomoyasu, Yamagishi, Sho-Ichi

“…Advanced glycation end products (AGEs) are localized in macrophage-derived foam cells within atherosclerotic lesions, which could be associated with the…”
Get full text

Analysis of pancreatic volume in acute‐onset, slowly‐progressive and fulminant type 1 diabetes in a Japanese population by Sasamori, Hiroto, Fukui, Tomoyasu, Hayashi, Toshiyuki, Yamamoto, Takeshi, Ohara, Makoto, Yamamoto, Saki, Kobayashi, Tetsuro, Hirano, Tsutomu

“…Aims/Introduction A decrease in the size of the pancreas is observed in islet autoantibody‐positive non‐diabetic donors and acute‐onset type 1 diabetes…”
Get full text

Very rare case of Graves’ disease with resistance to methimazole: a case report and literature review by Mori, Yusaku, Hiromura, Munenori, Terasaki, Michishige, Kushima, Hideki, Ohara, Makoto, Fukui, Tomoyasu, Takahashi, Yasuyoshi, Yamagishi, Sho-ichi

“…Background Methimazole (MMI) is used to treat hyperthyroidism in Graves’ disease. It is rare to encounter patients in whom hyperthyroidism cannot be controlled…”
Get full text

Sequential screening of biomarkers in a case of drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms occurring with virus reactivation and autoimmune disease by Lee, EunSeon, Lee, Suni, Tashiro, Yasuya, Ogihara, Mari, Watanabe, Hideaki, Ishibashi, Satoshi, Nagata, Shigeki, Miyo, Kana, Ohara, Makoto, Otsuki, Takemi, Sueki, Hirohiko

Get full text

Luseogliflozin inhibits high glucose-induced TGF-β2 expression in mouse cardiomyocytes by suppressing NHE-1 activity by Osaka, Naoya, Mori, Yusaku, Terasaki, Michishige, Hiromura, Munenori, Saito, Tomomi, Yashima, Hironori, Shiraga, Yoshie, Kawakami, Raichi, Ohara, Makoto, Fukui, Tomoyasu, Yamagishi, Sho-ichi

“…Objective Sodium-glucose cotransporter-2 (SGLT2) inhibitors exhibit cardioprotective properties in patients with diabetes. However, SGLT2 is not expressed in…”
Get full text

Prospective randomized comparative study of the effect of pemafibrate add‐on or double statin dose on small dense low‐density lipoprotein‐cholesterol in patients with type 2 diabetes and hypertriglyceridemia on statin therapy by Hirano, Tsutomu, Hayashi, Toshiyuki, Sugita, Hiroe, Tamasawa, Atsuko, Goto, Satoshi, Tomoyasu, Masako, Yamamoto, Takeshi, Ohara, Makoto, Terasaki, Michishige, Kushima, Hideki, Ito, Yasuki, Yamagishi, Sho‐ichi, Mori, Yusaku

“…Aims/Introduction Small dense low‐density lipoprotein (sdLDL) is a more potent atherogenic lipoprotein than LDL. As sdLDL‐cholesterol (C) levels are determined…”
Get full text

Comparison of positive rates between glutamic acid decarboxylase antibodies and ElisaRSR™ 3 Screen ICA™ in recently obtained sera from patients who had been previously diagnosed with slowly progressive type 1 diabetes by Takehana, Nobuaki, Fukui, Tomoyasu, Mori, Yusaku, Hiromura, Munenori, Terasaki, Michishige, Ohara, Makoto, Takada, Michiya, Tomoyasu, Masako, Ito, Yoshihisa, Kobayashi, Tetsuro, Yamagishi, Sho‐ichi

“…Aims/Introduction This study aimed to compare the positivity rates of glutamic acid decarboxylase autoantibodies (GADA) and ElisaRSR™ 3 Screen ICA™ (3 Screen…”
Get full text

Association between insulin-like growth factor 1 and pancreatic volume in type 1 and type 2 diabetes: cross-sectional study of a Japanese population by Fukui, Tomoyasu, Fukase, Ayako, Sasamori, Hiroto, Ohara, Makoto, Mori, Yusaku, Terasaki, Michishige, Hiromura, Munenori, Kushima, Hideki, Kobayashi, Tetsuro, Yamagishi, Sho-ichi

“…Although IGF-1 is known to promote organ growth, including exocrine pancreas, the association between plasma IGF-1 levels and pancreatic size remains unclear…”
Get full text

Circulating anti‐glutamic acid decarboxylase‐65 antibody titers are positively associated with the capacity of insulin secretion in acute‐onset type 1 diabetes with short duration in a Japanese population by Yamamura, So, Fukui, Tomoyasu, Mori, Yusaku, Hayashi, Toshiyuki, Yamamoto, Takeshi, Ohara, Makoto, Fukase, Ayako, Sasamori, Hiroto, Kobayashi, Tetsuro, Hirano, Tsutomu

“…Aims/Introduction To elucidate the relationship between titers of islet autoantibodies, the C‐X‐C motif chemokine 10 – a circulating chemokine that activates…”
Get full text

Effect of Dulaglutide Versus Liraglutide on Glucose Variability, Oxidative Stress, and Endothelial Function in Type 2 Diabetes: A Prospective Study by Nagaike, Hiroe, Ohara, Makoto, Kohata, Yo, Hiromura, Munenori, Tomoyasu, Masako, Takada, Michiya, Yamamoto, Takeshi, Hayashi, Toshiyuki, Fukui, Tomoyasu, Hirano, Tsutomu

“…Introduction To compare the effect of dulaglutide and liraglutide on oxidative stress and endothelial function in patients with type 2 diabetes mellitus…”
Get full text

Comparison of liraglutide plus basal insulin and basal-bolus insulin therapy (BBIT) for glycemic control, body weight stability, and treatment satisfaction in patients treated using BBIT for type 2 diabetes without severe insulin deficiency: A randomized prospective pilot study by Yamamoto, Saki, Hayashi, Toshiyuki, Ohara, Makoto, Goto, Satoshi, Sato, Jun, Nagaike, Hiroe, Fukase, Ayako, Sato, Nobuko, Hiromura, Munenori, Tomoyasu, Masako, Nakanishi, Noriko, Lee, Soushou, Osamura, Anna, Yamamoto, Takeshi, Fukui, Tomoyasu, Hirano, Tsutomu

“…We examined whether 0.9 mg/day liraglutide plus basal insulin (Lira-basal) is superior to basal-bolus insulin therapy (BBIT) for type 2 diabetes (T2DM) without…”
Get full text

Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice by Mori, Yusaku, Ohara, Makoto, Terasaki, Michishige, Osaka, Naoya, Yashima, Hironori, Saito, Tomomi, Otoyama-Kataoka, Yurie, Omachi, Takemasa, Higashimoto, Yuichiro, Matsui, Takanori, Fukui, Tomoyasu, Yamagishi, Sho-Ichi

“…We have developed DNA aptamers that can inhibit the toxic effects of advanced glycation end products (AGE-Apts). We herein evaluated the effects of AGE-Apts on…”
Get full text

Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes by Fukase, Ayako, Fukui, Tomoyasu, Sasamori, Hiroto, Hiromura, Munenori, Terasaki, Michishige, Mori, Yusaku, Hayashi, Toshiyuki, Yamamoto, Takeshi, Ohara, Makoto, Goto, Satoshi, Nagaike, Hiroe, Hirano, Tsutomu, Yamagishi, Sho‐ichi

“…Aims To clarify the clinical impact of pancreatic fat volume on beta cell function in type 2 diabetes patients. Materials and Methods One hundred thirty two…”
Get full text