Search Results - "Ohannesian, David"

Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells by OHANNESIAN, D. W, LOTAN, D, THOMAS, P, JESSUP, T. M, FUKUDA, M, GABIUS, H.-J, LOTAN, R

“…Galectin-1 and galectin-3, galactoside-binding lectins with molecular weights of M(r) 14,500 and 31,000, respectively, are expressed in normal and malignant…”
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Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea by Zhang, Qiwei, Ohannesian, David W, Erickson, Leonard C

“…O(6)-Methylguanine DNA methyltransferase (MGMT) protects tumor cells from the cytotoxic effects of DNA-alkylating agents such as…”
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Synthesis and preliminary biological evaluation of 6- O-[ 11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT by Liu, Xuan, Zheng, Qi-Huang, Fei, Xiangshu, Wang, Ji-Quan, Ohannesian, David W, Erickson, Leonard C, Stone, K.Lee, Hutchins, Gary D

“…Novel radiolabeled O 6-benzylguanine derivatives, 6- O-[ 11C]-[(methoxymethyl)benzyl]guanines ([ 11C] p- O 6-MMBG, 1a; [ 11C] m- O 6-MMBG, 1b; ([ 11C] o- O…”
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Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate by OHANNESIAN, D. W, LOTAN, D, LOTAN, R

“…Galactoside-binding lectins (galectins) with molecular masses of about 14.5 kilodaltons (galectin-1) and 31 kilodaltons (galectin-3) have been found in a…”
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Increased content of an endogenous lactose-binding lectin in human colorectal carcinoma progressed to metastatic stages by IRIMURA, T, MATSUSHITA, Y, SUTTON, R. C, CARRALERO, D, OHANNESIAN, D. W, CLEARY, K. R, OTA, D. M, NICOLSON, G. L, LOTAN, R

“…The quantity and localization of two lactose-binding lectins with molecular weights of 31,000 and 14,500 in human colorectal carcinoma tissue specimens…”
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Synthesis and preliminary biological evaluation of radiolabeled O6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in breast cancer by ZHENG, Qi-Huang, XUAN LIU, XIANGSHU FEI, WANG, Ji-Quan, OHANNESIAN, David W, ERICKSON, Leonard C, LEE STONE, K, HUTCHINS, Gary D

“…Novel radiolabeled O(6)-benzylguanine (O(6)-BG) derivatives, 2-amino-6-O-[(11)C]-[(methoxymethyl)benzyloxy]-9-methyl purines ([(11)C]p-O(6)-AMMP, 1a;…”
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Synthesis of radiolabeled O6-benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase by Zheng, Qi-Huang, Liu, Xuan, Fei, Xiangshu, Wang, Ji-Quan, Ohannesian, David W., Erickson, Leonard C., Stone, K. Lee, Martinez, Tanya D., Miller, Kathy D., Hutchins, Gary D.

“…Novel radiolabeled O6‐benzylguanine derivatives, 2‐amino‐6‐O‐[11C]‐[(methoxymethyl)benzyloxy]‐9‐benzyl purines ([11C]p‐O6‐AMBP, 1a; [11C]m‐O6‐AMBP, 1b;…”
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Mutational Analysis of a Leucine Heptad Repeat Motif in a Class I Aminoacyl-tRNA Synthetase by Ohannesian, David W, Oh, John, Hou, Ya-Ming

“…Aminoacyl-tRNA synthetases activate amino acids with ATP to form aminoacyl adenylates as the essential intermediates for aminoacylation of their cognate tRNAs…”
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Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression by Lotan, R, Matsushita, Y, Ohannesian, D, Carralero, D, Ota, D M, Cleary, K R, Nicolson, G L, Irimura, T

“…Lactose-binding lectins having Mr values of approximately 14,000 (L-14.5) and approximately 35,000 Da have been found in a variety of vertebrate tissues,…”
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Abstract LB-396: Molecular characterization of ED-SCLC: high-resolution SNP 6.0 arrays, mRNA expression, and miRNA arrays from the phase III GALES trial by Sandanaraj, Edwin, Myrand, Scott P., Aggarwal, Amit, Guba, Susan C., Ohannesian, David, Wang, Jian WJ, Yang, Yong YY, Scagliotti, Giorgio V., Smit, Egbert F.

“…Background Extensive-stage disease, small-cell lung cancer (ED-SCLC) is a lethal disease with poor clinical outcomes given current systemic therapy options…”
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Synthesis and preliminary biological evaluation of radiolabeled O 6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O 6-alkylguanine-DNA alkyltransferase in breast cancer by Zheng, Qi-Huang, Liu, Xuan, Fei, Xiangshu, Wang, Ji-Quan, Ohannesian, David W., Erickson, Leonard C., Lee Stone, K., Hutchins, Gary D.

“…Novel radiolabeled O 6-benzylguanine (O 6-BG) derivatives, 2-amino-6-O-[ 11C]-[(methoxymethyl)benzyloxy]-9-methyl purines ([ 11C] p-O 6-AMMP, 1a; [ 11C] m-O…”
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Synthesis of radiolabeled O 6 ‐benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O 6 ‐alkylguanine‐DNA alkyltransferase by Zheng, Qi‐Huang, Liu, Xuan, Fei, Xiangshu, Wang, Ji‐Quan, Ohannesian, David W., Erickson, Leonard C., Stone, K. Lee, Martinez, Tanya D., Miller, Kathy D., Hutchins, Gary D.

“…Novel radiolabeled O 6 ‐benzylguanine derivatives, 2‐amino‐6‐O‐[ 11 C]‐[(methoxymethyl)benzyloxy]‐9‐benzyl purines ([ 11 C] p ‐O 6 ‐AMBP, 1a ; [ 11 C] m ‐O 6…”
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Analysis of galectin expression and identification of endogenous ligands in a human colon carcinoma cell line by Ohannesian, David William

“…The 14.5 kDa (galectin-1) and 31 kDa (galectin-3) lectins are the most well characterized members of a family of vertebrate carbohydrate-binding proteins known…”
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