Search Results - "Ohama, Tohru"

Anti-GPIHBP1 Antibody-Positive Autoimmune Hyperchylomicronemia and Immune Thrombocytopenia by Tanaka, Katsunao, Koseki, Masahiro, Kato, Hisashi, Miyashita, Kazuya, Okada, Takeshi, Kanno, Kotaro, Saga, Ayami, Chang, Jiuyang, Omatsu, Takashi, Inui, Hiroyasu, Ohama, Tohru, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Primary hyperchylomicronemia is characterized by marked hypertriglyceridemia exceeding 1,000 mg/dL. It is caused by dysfunctional mutations in specific genes,…”
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Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction by Liu, Jingyi, Nishida, Makoto, Inui, Hiroyasu, Chang, Jiuyang, Zhu, Yinghong, Kanno, Kotaro, Matsuda, Hibiki, Sairyo, Masami, Okada, Takeshi, Nakaoka, Hajime, Ohama, Tohru, Masuda, Daisaku, Koseki, Masahiro, Yamashita, Shizuya, Sakata, Yasushi

“…Aim: A direct oral anti-coagulant, FXa inhibitor, has been applied to the clinical treatment of myocardial infarction (MI). Experimental studies in mice…”
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Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Coronary Heart Disease (PROSPECTIVE) by Yamashita, Shizuya, Arai, Hidenori, Bujo, Hideaki, Masuda, Daisaku, Ohama, Tohru, Ishibashi, Toshiyuki, Yanagi, Koji, Doi, Yasuji, Nakagawa, Satoshi, Yamashiro, Koichi, Tanabe, Kenichiro, Kita, Toru, Matsuzaki, Masunori, Saito, Yasushi, Fukushima, Masanori, Matsuzawa, Yuji, on Behalf of the PROSPECTIVE Study Group

“…Aims: Although intensive statin therapy reduced cardiovascular risks, cardiovascular events have not been completely prevented. Probucol is a potent…”
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Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy by Kanno, Kotaro, Koseki, Masahiro, Chang, Jiuyang, Saga, Ayami, Inui, Hiroyasu, Okada, Takeshi, Tanaka, Katsunao, Asaji, Masumi, Zhu, Yinghong, Ide, Seiko, Saito, Shigeyoshi, Higo, Tomoaki, Okuzaki, Daisuke, Ohama, Tohru, Nishida, Makoto, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Yamashita, Shizuya, Sakata, Yasushi

“…Although patients with nonalcoholic fatty liver disease have been reported to have cardiac dysfunction, and appropriate model has not been reported. We…”
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Development and Clinical Application of an Enzyme-Linked Immunosorbent Assay for Oxidized High-Density Lipoprotein by Okada, Takeshi, Sumida, Mizuki, Ohama, Tohru, Katayama, Yuki, Saga, Ayami, Inui, Hiroyasu, Kanno, Kotaro, Masuda, Daisaku, Koseki, Masahiro, Nishida, Makoto, Sakata, Yasushi, Yamashita, Shizuya

“…Aims: HDL particles have various anti-atherogenic functions, whereas HDL from atherosclerotic patients was demonstrated to be dysfunctional. One possible…”
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Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice by Nishihara, Sae, Koseki, Masahiro, Tanaka, Katsunao, Omatsu, Takashi, Saga, Ayami, Sawabe, Hiroshi, Inui, Hiroyasu, Okada, Takeshi, Ohama, Tohru, Okuzaki, Daisuke, Kamada, Yoshihiro, Ono, Masafumi, Nishida, Makoto, Watanabe, Mikio, Sakata, Yasushi

“…We previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular…”
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Proteomic Analysis of Human Chylomicron Remnants Isolated by Apolipoprotein B-48 Immunoprecipitation by Masuda, Daisaku, Okada, Takeshi, Sairyou, Masami, Takafuji, Kazuaki, Ohama, Tohru, Koseki, Masahiro, Nishida, Makoto, Sakata, Yasushi, Yamashita, Shizuya

“…Aim: Postprandial hypertriglyceridemia (PHTG) is an independent risk factor for coronary heart diseases. PHTG exhibits accumulation of apoB-48 containing…”
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Twin Study: The Factors Affecting the Serum LDL-C and HDL-C Levels and an RNA-Seq Analysis in Mononuclear Cells in Monozygotic Twins by Nishihara, Sae, Koseki, Masahiro, Tanaka, Katsunao, Omatsu, Takashi, Sawabe, Hiroshi, Inui, Hiroyasu, Saga, Ayami, Okada, Takeshi, Higo, Tomoaki, Ohama, Tohru, Nishida, Makoto, Sakata, Yasushi, Watanabe, Mikio, Group, Osaka Twin Research

“…Aim: A twin study is a valuable tool for elucidating the acquired factors against lifestyle diseases such as dyslipidemia, diabetes mellitus, and obesity. We…”
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Effects of a Dipeptidyl Peptidase 4 Inhibitor Sitagliptin on Glycemic Control and Lipoprotein Metabolism in Patients with Type 2 Diabetes Mellitus (GLORIA Trial) by Masuda, Daisaku, Kobayashi, Takuya, Sairyou, Masami, Hanada, Hiroyuki, Ohama, Tohru, Koseki, Masahiro, Nishida, Makoto, Maeda, Norikazu, Kihara, Shinji, Minami, Tatsuya, Yanagi, Koji, Sakata, Yasushi, Yamashita, Shizuya

“…Aim: The morbidity of cardiovascular disease in patients with type 2 diabetes mellitus (DM) deteriorates in combination with dyslipidemia. The accumulation of…”
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DEVELOPMENT AND CLINICAL APPLICATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY FOR OXIDIZED HIGH DENSITY LIPOPROTEIN by Okada, Takeshi, Ohama, Tohru, Saga, Ayami, Inui, Hiroyasu, Kanno, Kotaro, Koseki, Masahiro, Nishida, Makoto, Sakata, Hasashi, Yamashita, Shizuya

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Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice by Kawase, Ryota, Ohama, Tohru, Matsuyama, Akifumi, Matsuwaki, Takashi, Okada, Takeshi, Yamashita, Taiji, Yuasa-Kawase, Miyako, Nakaoka, Hajime, Nakatani, Kazuhiro, Inagaki, Miwako, Tsubakio-Yamamoto, Kazumi, Masuda, Daisaku, Nakagawa-Toyama, Yumiko, Nishida, Makoto, Ohmoto, Yasukazu, Nishihara, Masugi, Komuro, Issei, Yamashita, Shizuya

“…Progranulin (PGRN) is a multifunctional protein known to be involved in inflammation. However, the relation between PGRN and atherosclerosis remains elusive…”
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A Novel Selective PPARα Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice by Sairyo, Masami, Kobayashi, Takuya, Masuda, Daisaku, Kanno, Koutaro, Zhu, Yinghong, Okada, Takeshi, Koseki, Masahiro, Ohama, Tohru, Nishida, Makoto, Sakata, Yasushi, Yamashita, Shizuya

“…Aims: Fasting and postprandial hypertriglyceridemia (PHTG) are caused by the accumulation of triglyceride (TG)-rich lipoproteins and their remnants, which have…”
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Klotho-related Molecules Upregulated by Smoking Habit in Apparently Healthy Men: A Cross-sectional Study by Nakanishi, Kaori, Nishida, Makoto, Harada, Masaya, Ohama, Tohru, Kawada, Noritaka, Murakami, Masaaki, Moriyama, Toshiki, Yamauchi-Takihara, Keiko

“…While aging is unavoidable, the aging mechanism is still unclear because of its complexity. Smoking causes premature death and is considered as an…”
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A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice by Saga, Ayami, Koseki, Masahiro, Kanno, Kotaro, Chang, Jiuyang, Higo, Tomoaki, Okuzaki, Daisuke, Okada, Takeshi, Inui, Hiroyasu, Asaji, Masumi, Tanaka, Katsunao, Omatsu, Takashi, Nishihara, Sae, Zhu, Yinghong, Ito, Kaori, Hattori, Hiroaki, Ichi, Ikuyo, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Ohama, Tohru, Hikoso, Shungo, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Patients with psoriasis are at a higher risk of developing nonalcoholic fatty liver disease. We previously identified an oxidized derivative of cholesterol,…”
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Accelerated Atherogenicity in Tangier Disease A Case Accompanied by Extensive Atherosclerotic Lesions, Leriche Syndrome and Bleeding Tendency, and Review of the Literature by Muratsu, Jun, Koseki, Masahiro, Masuda, Daisaku, Yasuga, Yuji, Tomoyama, Satoki, Ataka, Keiji, Yagi, Yoshiki, Nakagawa, Atsushi, Hamada, Hidehumi, Fujita, Shigeki, Hattori, Hiroaki, Ohama, Tohru, Nishida, Makoto, Hiraoka, Hisatoyo, Matsuzawa, Yuji, Yamashita, Shizuya

“…We report a case of Tangier disease with Leriche syndrome and bleeding tendency. In this male patient, nasal hemorrhage had been observed frequently throughout…”
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Molecular Mechanisms of HDL-Cholesterol Elevation by Statins and Its Effects on HDL Functions by Yamashita, Shizuya, Tsubakio-Yamamoto1, Kazumi, Ohama, Tohru, Nakagawa-Toyama, Yumiko, Nishida, Makoto

“…Numerous large-scale clinical studies have revealed that the low-density lipoprotein cholesterol (LDL-C)-lowering effect of 3-hydroxy-3-methylglutaryl-CoA…”
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Smoking Associates With Visceral Fat Accumulation Especially in Women by Nakanishi, Kaori, Nishida, Makoto, Ohama, Tohru, Moriyama, Toshiki, Yamauchi-Takihara, Keiko

“…Background: Smoking and metabolic syndrome (MetS) are major public health problems in modern society and are important risk factors of cardiovascular disease…”
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Particle number analysis of lipoprotein subclasses by gel permeation HPLC in patients with cholesteryl ester transfer protein deficiency by Okada, Takeshi, Ohama, Tohru, Okazaki, Mitsuyo, Kanno, Kotaro, Matsuda, Hibiki, Sairyo, Masami, Zhu, Yinghong, Saga, Ayami, Kobayashi, Takuya, Masuda, Daisaku, Koseki, Masahiro, Nishida, Makoto, Sakata, Yasushi, Yamashita, Shizuya

“…We previously reported that patients with cholesteryl ester transfer protein (CETP) deficiency (CETP-D) have a higher prevalence of atherosclerotic…”
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Dietary Oxysterol, 7-Ketocholesterol Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice by Chang, Jiuyang, Koseki, Masahiro, Saga, Ayami, Kanno, Kotaro, Higo, Tomoaki, Okuzaki, Daisuke, Okada, Takeshi, Inui, Hiroyasu, Tanaka, Katsunao, Asaji, Masumi, Zhu, Yinghong, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Ichi, Ikuyo, Ohama, Tohru, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Non-alcoholic fatty liver disease is strongly associated with obese and type 2 diabetes. It has been reported that an oxidized cholesterol, 7-ketocholesterol…”
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HDL/Apolipoprotein A-I Binds to Macrophage-Derived Progranulin and Suppresses its Conversion into Proinflammatory Granulins by Okura, Hanayuki, Yamashita, Shizuya, Ohama, Tohru, Saga, Ayami, Yamamoto-Kakuta, Aya, Hamada, Yoko, Sougawa, Nagako, Ohyama, Reiko, Sawa, Yoshiki, Matsuyama, Akifumi

“…Aim: HDL has anti-inflammatory effects on macrophages, although the mechanism of action remains unclear. We hypothesized that HDL suppresses the conversion of…”
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