Search Results - "Oh, Chang‐Myung"
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Beneficial Effects of Time-Restricted Eating on Metabolic Diseases: A Systemic Review and Meta-Analysis
Published in Nutrients (29-04-2020)“…Various behavioral and physiological pathways follow a pre-determined, 24 hour cycle known as the circadian rhythm. Metabolic homeostasis is regulated by the…”
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SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
Published in Nature communications (01-05-2020)“…Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type 2 diabetes (T2D); however, the underlying mechanism remains…”
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Combination Immunotherapy Using Oncolytic Virus for the Treatment of Advanced Solid Tumors
Published in International journal of molecular sciences (19-10-2020)“…Oncolytic virus (OV) is a new therapeutic strategy for cancer treatment. OVs can selectively infect and destroy cancer cells, and therefore act as an in situ…”
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The Effect of Anxiety and Depression on Sleep Quality of Individuals With High Risk for Insomnia: A Population-Based Study
Published in Frontiers in neurology (13-08-2019)“…One of the most common sleep disorders, insomnia is a significant public health concern. Several psychiatric disorders, such as anxiety disorders and…”
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Association of low muscle mass and obesity with increased all‐cause and cardiovascular disease mortality in US adults
Published in Journal of cachexia, sarcopenia and muscle (01-02-2024)“…Background Sarcopenic obesity, defined as the coexistence of low muscle mass and high adiposity, is associated with cardiovascular disease (CVD) and mortality…”
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NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
Published in Cell reports (Cambridge) (19-01-2021)“…Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and…”
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Serotonin in the regulation of systemic energy metabolism
Published in Journal of diabetes investigation (01-10-2022)“…Serotonin is a well‐known neurotransmitter that is synthesized from the amino acid, tryptophan. To date, more than 14 different serotonin receptors have been…”
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Development and validation of a new diabetes index for the risk classification of present and new-onset diabetes: multicohort study
Published in Scientific reports (03-08-2021)“…In this study, we aimed to propose a novel diabetes index for the risk classification based on machine learning techniques with a high accuracy for diabetes…”
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Functional Role of Serotonin in Insulin Secretion in a Diet-Induced Insulin-Resistant State
Published in Endocrinology (Philadelphia) (01-02-2015)“…The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model…”
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Visit-to-visit HbA1c and glucose variability and the risks of macrovascular and microvascular events in the general population
Published in Scientific reports (04-02-2019)“…This study evaluate association between glycemic variability and adverse vascular events in nondiabetic middle-aged adults. From 10,020 Ansung-Ansan cohort,…”
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The Interplay of Adipokines and Pancreatic Beta Cells in Metabolic Regulation and Diabetes
Published in Biomedicines (01-09-2023)“…The interplay between adipokines and pancreatic beta cells, often referred to as the adipo-insular axis, plays a crucial role in regulating metabolic…”
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Comparative Transcriptome Profiling of Young and Old Brown Adipose Tissue Thermogenesis
Published in International journal of molecular sciences (05-12-2021)“…Brown adipose tissue (BAT) is a major site for uncoupling protein 1 (UCP1)-mediated non-shivering thermogenesis. BAT dissipates energy via heat generation to…”
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Regulation of systemic energy homeostasis by serotonin in adipose tissues
Published in Nature communications (13-04-2015)“…Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy…”
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Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Published in Experimental & molecular medicine (01-08-2023)“…Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and,…”
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Smoking and passive smoking increases mortality through mediation effect of cadmium exposure in the United States
Published in Scientific reports (08-03-2023)“…Cigarette smoking is one of the leading causes of preventable and premature death worldwide. Even worse, many people are generally exposed to passive smoking,…”
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Integrative single‐cell transcriptome analysis provides new insights into post‐COVID‐19 pulmonary fibrosis and potential therapeutic targets
Published in Journal of medical virology (01-11-2023)“…The global COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 virus has resulted in a significant number of patients experiencing…”
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Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity
Published in Diabetes & metabolism journal (01-04-2016)“…Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT…”
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A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis
Published in International journal of molecular sciences (28-02-2021)“…Obesity has become a global public health and economic problem. Obesity is a major risk factor for a number of complications, such as type 2 diabetes,…”
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Identifying gene function and module connections by the integration of multispecies expression compendia
Published in Genome research (01-12-2019)“…The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two…”
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The influence of physical activity on risk of cardiovascular disease in people who are obese but metabolically healthy
Published in PloS one (26-09-2017)“…The metabolic outcomes of metabolically healthy obesity (MHO) remain controversial. The aim of the present study was to determine the effect of physical…”
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