Search Results - "Oh, Byung Ha"

Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex by Kim, Hyunmin, Kubori, Tomoko, Yamazaki, Kohei, Kwak, Mi-Jeong, Park, Suk-Youl, Nagai, Hiroki, Vogel, Joseph P., Oh, Byung-Ha

“…The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) is extremely versatile, translocating ~300 effector proteins into host cells. This…”
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Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins by Yu, Daseuli, Lee, Hansol, Hong, Jongryul, Jung, Hyunjin, Jo, YoungJu, Oh, Byung-Ha, Park, Byung Ouk, Heo, Won Do

“…Intracellular antibodies have become powerful tools for imaging, modulating and neutralizing endogenous target proteins. Here, we describe an optogenetically…”
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A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy by Giordano-Attianese, Greta, Gainza, Pablo, Gray-Gaillard, Elise, Cribioli, Elisabetta, Shui, Sailan, Kim, Seonghoon, Kwak, Mi-Jeong, Vollers, Sabrina, Corria Osorio, Angel De Jesus, Reichenbach, Patrick, Bonet, Jaume, Oh, Byung-Ha, Irving, Melita, Coukos, George, Correia, Bruno E.

“…Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side…”
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Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX by Ku, Bonsu, Liang, Chengyu, Jung, Jae U, Oh, Byung-Ha

“…Interactions between the BCL-2 family proteins determine the cell＇s fate to live or die. How they interact with each other to regulate apoptosis remains as an…”
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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG by Jung, Jae U, Liang, Chengyu, Feng, Pinghui, Ku, Bonsu, Dotan, Iris, Canaani, Dan, Oh, Byung-Ha

“…Autophagy, the degradation of cytoplasmic components, is an evolutionarily conserved homeostatic process involved in environmental adaptation, lifespan…”
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DeSUMOylating isopeptidase: a second class of SUMO protease by Shin, Eun Ju, Shin, Hyun Mi, Nam, Eori, Kim, Won Seog, Kim, Ji-Hoon, Oh, Byung-Ha, Yun, Yungdae

“…The modification of proteins by small ubiquitin‐like modifier (SUMO) is crucial for the regulation of diverse cellular processes. Protein SUMOylation is…”
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Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization by Diebold-Durand, Marie-Laure, Lee, Hansol, Ruiz Avila, Laura B., Noh, Haemin, Shin, Ho-Chul, Im, Haeri, Bock, Florian P., Bürmann, Frank, Durand, Alexandre, Basfeld, Alrun, Ham, Sihyun, Basquin, Jérôme, Oh, Byung-Ha, Gruber, Stephan

“…Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double…”
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SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis by Wilhelm, Larissa, Bürmann, Frank, Minnen, Anita, Shin, Ho-Chul, Toseland, Christopher P, Oh, Byung-Ha, Gruber, Stephan

“…Smc-ScpAB forms elongated, annular structures that promote chromosome segregation, presumably by compacting and resolving sister DNA molecules. The mechanistic…”
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Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses by Liang, Qiming, Seo, Gil Ju, Choi, Youn Jung, Kwak, Mi-Jeong, Ge, Jianning, Rodgers, Mary A., Shi, Mude, Leslie, Benjamin J., Hopfner, Karl-Peter, Ha, Taekjip, Oh, Byung-Ha, Jung, Jae U.

“…Robust immune responses are essential for eliminating pathogens but must be metered to avoid prolonged immune activation and potential host damage. Upon…”
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Crystal structure of PYCH_01220 from Pyrococcus yayanosii potentially involved in binding nucleic acid by Noh, Haemin, Jeon, Jae‐Hyun, Kim, Yeon‐Gil, Oh, Byung‐Ha

“…We report the crystal structure of PYCH_01220, a hypothetical protein in Pyrococcus yayanosii CH1. This protein is composed of two domains, named Domain A and…”
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Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes by Petela, Naomi J, Gonzalez Llamazares, Andres, Dixon, Sarah, Hu, Bin, Lee, Byung-Gil, Metson, Jean, Seo, Heekyo, Ferrer-Harding, Antonio, Voulgaris, Menelaos, Gligoris, Thomas, Collier, James, Oh, Byung-Ha, Löwe, Jan, Nasmyth, Kim A

“…Cohesin's association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA…”
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Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut by Lee, Won-Jae, Ha, Eun-Mi, Lee, Kyung-Ah, Seo, You Yeong, Kim, Sung-Hee, Lim, Jae-Hong, Oh, Byung-Ha, Kim, Jaesang

“…The gut immune system distinguishes commensal from dangerous microbes. Lee and colleagues delineate a pathway that 'fine tunes' the production of microbicidal…”
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Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus by Yun, Hye-Yeoung, Kim, Min Wook, Lee, Hye Seon, Kim, Wantae, Shin, Ji Hye, Kim, Hyunmin, Shin, Ho-Chul, Park, Hwangseo, Oh, Byung-Ha, Kim, Won Kon, Bae, Kwang-Hee, Lee, Sang Chul, Lee, Eun-Woo, Ku, Bonsu, Kim, Seung Jun

“…Human papillomaviruses (HPVs) are causative agents of various diseases associated with cellular hyperproliferation, including cervical cancer, one of the most…”
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Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision by Ahn, Woo-Chan, Aroli, Shashanka, Kim, Jin-Hahn, Moon, Jeong Hee, Lee, Ga Seal, Lee, Min-Ho, Sang, Pau Biak, Oh, Byung-Ha, Varshney, Umesh, Woo, Eui-Jeon

“…Uracil DNA glycosylases (UDGs) are important DNA repair enzymes that excise uracil from DNA, yielding an abasic site. Recently, UdgX, an unconventional UDG…”
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Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding by Soh, Young-Min, Bürmann, Frank, Shin, Ho-Chul, Oda, Takashi, Jin, Kyeong Sik, Toseland, Christopher P., Kim, Cheolhee, Lee, Hansol, Kim, Soo Jin, Kong, Min-Seok, Durand-Diebold, Marie-Laure, Kim, Yeon-Gil, Kim, Ho Min, Lee, Nam Ki, Sato, Mamoru, Oh, Byung-Ha, Gruber, Stephan

“…SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil,…”
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Crystal Structure of the Csm1 Subunit of the Csm Complex and Its Single-Stranded DNA-Specific Nuclease Activity by Jung, Tae-Yang, An, Yan, Park, Kwang-Hyun, Lee, Min-Ho, Oh, Byung-Ha, Woo, Euijeon

“…The CRISPR-Cas system is the RNA-guided immune defense mechanism in bacteria and archaea. Csm1 belongs to the Cas10 family, which is the common signature…”
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Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity by Song, Jinyeop, Jeong, Bo-Seong, Kim, Seong-Woo, Im, Seong-Bin, Kim, Seonghoon, Lai, Chih-Jen, Cho, Wonki, Jung, Jae U, Ahn, Myung-Ju, Oh, Byung-Ha

“…Immunoglobulin G (IgG) antibodies are widely used for diagnosis and therapy. Given the unique dimeric structure of IgG, we hypothesized that, by genetically…”
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Crystal structure and nucleic acid-binding activity of the CRISPR-associated protein Csx1 of Pyrococcus furiosus by Kim, Young Kwan, Kim, Yeon-Gil, Oh, Byung-Ha

“…In many prokaryotic organisms, chromosomal loci known as clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR‐associated (CAS) genes…”
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Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis by Park, Suk-Youl, Park, Jung-Eun, Kim, Tae-Sung, Kim, Ju Hee, Kwak, Mi-Jeong, Ku, Bonsu, Tian, Lan, Murugan, Ravichandran N, Ahn, Mija, Komiya, Shinobu, Hojo, Hironobu, Kim, Nam-Hyung, Kim, Bo Yeon, Bang, Jeong K, Erikson, Raymond L, Lee, Ki Won, Kim, Seung Jun, Oh, Byung-Ha, Yang, Wei, Lee, Kyung S

“…Plk4 regulates centriole duplication. Two centrosomal scaffold proteins, Cep192 and Cep152, are shown to interact with Plk4 in a temporally and spatially…”
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Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants by Jeong, Bo-Seong, Cha, Jeong Seok, Hwang, Insu, Kim, Uijin, Adolf-Bryfogle, Jared, Coventry, Brian, Cho, Hyun-Soo, Kim, Kyun-Do, Oh, Byung-Ha

“…Coronavirus disease 2019, caused by SARS-CoV-2, remains an on-going pandemic, partly due to the emergence of variant viruses that can "break-through" the…”
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