Search Results - "Oguro, Ryosuke"

Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice by Takeshita, Hikari, Yamamoto, Koichi, Nozato, Satoko, Inagaki, Tadakatsu, Tsuchimochi, Hirotsugu, Shirai, Mikiyasu, Yamamoto, Ryohei, Imaizumi, Yuki, Hongyo, Kazuhiro, Yokoyama, Serina, Takeda, Masao, Oguro, Ryosuke, Takami, Yoichi, Itoh, Norihisa, Takeya, Yasushi, Sugimoto, Ken, Fukada, So-ichiro, Rakugi, Hiromi

“…The conventional forelimb grip strength test is a widely used method to assess skeletal muscle function in rodents; in this study, we modified this method to…”
Get full text

The impact of visit-to-visit variability in blood pressure on renal function by Kawai, Tatsuo, Ohishi, Mitsuru, Kamide, Kei, Onishi, Miyuki, Takeya, Yasushi, Tatara, Yuji, Oguro, Ryosuke, Yamamoto, Koichi, Sugimoto, Ken, Rakugi, Hiromi

“…Hypertension is an important risk factor for cardiovascular diseases such as chronic kidney disease. It is still not fully understood how blood pressure…”
Get full text

Loss of ACE2 Exaggerates High-Calorie Diet―Induced Insulin Resistance by Reduction of GLUT4 in Mice by TAKEDA, Masao, YAMAMOTO, Koichi, TAKEYA, Yasushi, SUGIMOTO, Ken, KAMIDE, Kei, OHISHI, Mitsuru, RAKUGI, Hiromi, TAKEMURA, Yukihiro, TAKESHITA, Hikari, HONGYO, Kazuhiro, KAWAI, Tatsuo, HANASAKI-YAMAMOTO, Hiroko, OGURO, Ryosuke, TAKAMI, Yoichi, TATARA, Yuji

“…ACE type 2 (ACE2) functions as a negative regulator of the renin-angiotensin system by cleaving angiotensin II (AII) into angiotensin 1-7 (A1-7). This study…”
Get full text

Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study by Ikebe, Kazunori, Gondo, Yasuyuki, Kamide, Kei, Masui, Yukie, Ishizaki, Taturo, Arai, Yasumichi, Inagaki, Hiroki, Nakagawa, Takeshi, Kabayama, Mai, Ryuno, Hirochika, Okubo, Hitomi, Takeshita, Hajime, Inomata, Chisato, Kurushima, Yuko, Mihara, Yusuke, Hatta, Kohdai, Fukutake, Motoyoshi, Enoki, Kaori, Ogawa, Taiji, Matsuda, Ken-Ichi, Sugimoto, Ken, Oguro, Ryosuke, Takami, Yoichi, Itoh, Norihisa, Takeya, Yasushi, Yamamoto, Koichi, Rakugi, Hiromi, Murakami, Shinya, Kitamura, Masahiro, Maeda, Yoshinobu

“…Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on…”
Get full text

Carotid plaque score and intima media thickness as predictors of stroke and mortality in hypertensive patients by Kawai, Tatsuo, Ohishi, Mitsuru, Takeya, Yasushi, Onishi, Miyuki, Ito, Norihisa, Oguro, Ryosuke, Yamamoto, Koichi, Kamide, Kei, Rakugi, Hiromi

“…The mean intima media thickness (IMT) and plaque score from carotid ultrasonography are both widely used to evaluate macrovascular atherosclerotic change. The…”
Get full text

Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study by Ryuno, Hirochika, Kamide, Kei, Gondo, Yasuyuki, Kabayama, Mai, Oguro, Ryosuke, Nakama, Chikako, Yokoyama, Serina, Nagasawa, Motonori, Maeda-Hirao, Satomi, Imaizumi, Yuki, Takeya, Miyuki, Yamamoto, Hiroko, Takeda, Masao, Takami, Yoichi, Itoh, Norihisa, Takeya, Yasushi, Yamamoto, Koichi, Sugimoto, Ken, Nakagawa, Takeshi, Yasumoto, Saori, Ikebe, Kazunori, Inagaki, Hiroki, Masui, Yukie, Takayama, Michiyo, Arai, Yasumichi, Ishizaki, Tatsuro, Takahashi, Ryutaro, Rakugi, Hiromi

“…Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of…”
Get full text

The counterregulating role of ACE2 and ACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation in vascular cells by Hayashi, Norihiro, Yamamoto, Koichi, Ohishi, Mitsuru, Tatara, Yuji, Takeya, Yasushi, Shiota, Atsushi, Oguro, Ryosuke, Iwamoto, Yoshihiro, Takeda, Masao, Rakugi, Hiromi

“…To clarify the role of endogenous angiotensin (Ang)-converting enzyme 2 (ACE2) and its cleavage product, Ang 1-7, in the atherogenic stimulation of vascular…”
Get full text

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin‐like oxLDL receptor by Yamamoto, Koichi, Kakino, Akemi, Takeshita, Hikari, Hayashi, Norihiro, Li, Lei, Nakano, Atsushi, Hanasaki‐Yamamoto, Hiroko, Fujita, Yoshiko, Imaizumi, Yuki, Toyama‐Yokoyama, Serina, Nakama, Chikako, Kawai, Tatsuo, Takeda, Masao, Hongyo, Kazuhiro, Oguro, Ryosuke, Maekawa, Yoshihiro, Itoh, Norihisa, Takami, Yoichi, Onishi, Miyuki, Takeya, Yasushi, Sugimoto, Ken, Kamide, Kei, Nakagami, Hironori, Ohishi, Mitsuru, Kurtz, Theodore W., Sawamura, Tatsuya, Rakugi, Hiromi

“…The angiotensin II type 1 receptor (AT1) is a 7‐transmembrane domain GPCR that when activated by its ligand angiotensin II, generates signaling events…”
Get full text

Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway by Maekawa, Yoshihiro, Ohishi, Mitsuru, Ikushima, Masashi, Yamamoto, Koichi, Yasuda, Osamu, Oguro, Ryosuke, Yamamoto-Hanasaki, Hiroko, Tatara, Yuji, Takeya, Yasushi, Rakugi, Hiromi

“…Aim:  Mice that carry the Klotho mutation (KL‐/‐) manifest diverse age‐related disorders similar to those observed in humans. Thus, the Klotho protein might…”
Get full text

Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC study by Ryuno, Hirochika, Kamide, Kei, Gondo, Yasuyuki, Nakama, Chikako, Oguro, Ryosuke, Kabayama, Mai, Kawai, Tatsuo, Kusunoki, Hiroshi, Yokoyama, Serina, Imaizumi, Yuki, Takeya, Miyuki, Yamamoto, Hiroko, Takeda, Masao, Takami, Yoichi, Itoh, Norihisa, Yamamoto, Koichi, Takeya, Yasushi, Sugimoto, Ken, Nakagawa, Takeshi, Ikebe, Kazunori, Inagaki, Hiroki, Masui, Yukie, Ishizaki, Tatsuro, Takayama, Michiyo, Arai, Yasumichi, Takahashi, Ryutaro, Rakugi, Hiromi

“…High blood pressure in middle age (up to 64 years) has been proposed as a predictive indicator of dementia. However, the association between hypertension and…”
Get full text

Serum albumin/globulin ratio is associated with cognitive function in community‐dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study by Maeda, Satomi, Takeya, Yasushi, Oguro, Ryosuke, Akasaka, Hiroshi, Ryuno, Hirochika, Kabayama, Mai, Yokoyama, Serina, Nagasawa, Motonori, Fujimoto, Taku, Takeda, Masao, Onishi‐Takeya, Miyuki, Itoh, Norihisa, Takami, Yoichi, Yamamoto, Koichi, Sugimoto, Ken, Inagaki, Hiroki, Ogawa, Madoka, Nakagawa, Takeshi, Yasumoto, Saori, Masui, Yukie, Arai, Yasumichi, Ishizaki, Tatsuro, Ikebe, Kazunori, Gondo, Yasuyuki, Kamide, Kei, Rakugi, Hiromi

“…Aim The objective of this study was to clarify the relationship between cognitive function and the serum albumin/globulin ratio (A/G ratio) in…”
Get full text

Prognostic impact of regional arterial stiffness in hypertensive patients by Kawai, Tatsuo, Ohishi, Mitsuru, Onishi, Miyuki, Ito, Norihisa, Takeya, Yasushi, Oguro, Ryosuke, Takami, Yoichi, Yamamoto, Koichi, Rakugi, Hiromi

“…Many reports have shown that brachial–ankle pulse wave velocity (baPWV) and carotid–femoral PWV are prognostic factors for cardiovascular diseases. We…”
Get full text

Factors associated with the severity of obstructive sleep apnea in older adults by Hongyo, Kazuhiro, Ito, Norihisa, Yamamoto, Koichi, Yasunobe, Yukiko, Takeda, Masao, Oguro, Ryosuke, Takami, Yoichi, Takeya, Yasushi, Sugimoto, Ken, Rakugi, Hiromi

“…Aim Epidemiological studies have shown that severe obstructive sleep apnea (OSA) is associated with higher mortality when compared with mild to moderate OSA…”
Get full text

Adiponectin Single Nucleotide Polymorphism is a Genetic Risk Factor for Stroke Through High Pulse Wave Pressure: A Cohort Study by Kawai, Tatsuo, Ohishi, Mitsuru, Takeya, Yasushi, Onishi, Miyuki, Ito, Norihisa, Yamamoto, Koichi, Oguro, Ryosuke, Kamide, Kei, Rakugi, Hiromi

“…Aim: Adiponectin is a key molecule involved in metabolic syndrome. Single nucleotide polymorphisms (SNPs) in the ADIPOQ gene encoding adiponectin correlate…”
Get full text

Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography by Kawai, Tatsuo, Kamide, Kei, Onishi, Miyuki, Hongyo, Kazuhiro, Yamamoto-Hanasaki, Hiroko, Oguro, Ryosuke, Maekawa, Yoshihiro, Yamamoto, Koichi, Takeya, Yasushi, Sugimoto, Ken, Ohishi, Mitsuru, Rakugi, Hiromi

“…Background Aging is well known as one of the major causes of a reduced glomerular filtration rate (GFR). The resistive index (RI) measured by renal Doppler…”
Get full text

Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population by Nakayama, Hiroyuki, Nagai, Hiromi, Matsumoto, Kyotaka, Oguro, Ryosuke, Sugimoto, Ken, Kamide, Kei, Ohishi, Mitsuru, Katsuya, Tomohiro, Okamoto, Hiroshi, Maeda, Makiko, Komamura, Kazuo, Azuma, Junichi, Rakugi, Hiromi, Fujio, Yasushi

“…Heart failure with preserved ejection fraction is recently highlighted as a major health problem, and diastolic dysfunction associated with hypertension has a…”
Get full text

Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension by Oguro, Ryosuke, Kamide, Kei, Kokubo, Yoshihiro, Shimaoka, Izumi, Congrains, Ada, Horio, Takeshi, Hanada, Hironori, Ohishi, Mitsuru, Katsuya, Tomohiro, Okamura, Tomonori, Miyata, Toshiyuki, Kawano, Yuhei, Rakugi, Hiromi

“…Aim:  Previous studies suggest that klotho gene polymorphisms may be associated with atherosclerosis, but did not assess the relationship between klotho gene…”
Get full text

Klotho gene delivery suppresses oxidative stress in vivo by Ohta, Junsuke, Rakugi, Hiromi, Ishikawa, Kazuhiko, Yang, Jin, Ikushima, Masashi, Chihara, Yukana, Maekawa, Yoshihiro, Oguro, Ryosuke, Hanasaki, Hiroko, Kida, Iwao, Matsukawa, Naomichi, Ogihara, Toshio

“…Objective:  Mice deficient in the klotho gene exhibit a syndrome resembling premature human aging. A recent report also suggested that klotho transgenic mice…”
Get full text

Klotho suppresses TNF-α-induced expression of adhesion molecules in the endothelium and attenuates NF-κB activation by Maekawa, Yoshihiro, Ishikawa, Kazuhiko, Yasuda, Osamu, Oguro, Ryosuke, Hanasaki, Hiroko, Kida, Iwao, Takemura, Yukihiro, Ohishi, Mitsuru, Katsuya, Tomohiro, Rakugi, Hiromi

“…Klotho is a senescence suppressor protein that, when overexpressed, extends the lifespan of mice. Klotho-disrupted mice exhibit atherosclerosis and endothelial…”
Get full text

Association between dietary patterns and cognitive function among 70-year-old Japanese elderly: a cross-sectional analysis of the SONIC study by Okubo, Hitomi, Inagaki, Hiroki, Gondo, Yasuyuki, Kamide, Kei, Ikebe, Kazunori, Masui, Yukie, Arai, Yasumichi, Ishizaki, Tatsuro, Sasaki, Satoshi, Nakagawa, Takeshi, Kabayama, Mai, Sugimoto, Ken, Rakugi, Hiromi, Maeda, Yoshinobu

“…An increasing number of studies in Western countries have shown that healthy dietary patterns may have a protective effect against cognitive decline and…”
Get full text