In Vivo Antiplasmodial Potential of the Leaf, Mesocarp, and Epicarp of the Raphia hookeri Plant in Mice Infected with Plasmodium berghei NK65

In Vivo Antiplasmodial Potential of the Leaf, Mesocarp, and Epicarp of the Raphia hookeri Plant in Mice Infected with Plasmodium berghei NK65

Background of the study. Raphia hookeri G. Mann & H. Wendl (Arecaceae) is an important plant used in folkloric medicine to treat various ailments such as inflammation, tumor, microbial infections, paralysis, hypertension, and rheumatism, primarily in Africa and Asia. Aim and Objectives. The stud...

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Published in:Evidence-based complementary and alternative medicine Vol. 2022; pp. 1 - 9
Main Authors: Oluyori, Abimbola Peter, Nwonuma, Charles, Akpo, Theresa, Inyinbor, Adejumoke Abosede, Dada, Oluwasogo Adewumi, Oladeji, Oluwole Solomon, Ogunnupebi, Temitope Aminat
Format: Journal Article
Language:English
Published: New York Hindawi 13-07-2022
Hindawi Limited
Subjects:
Acids
Antioxidants
Antiprotozoal agents
Blood
Chloroquine
Drug resistance
Flavonoids
Free radicals
Gas chromatography
Inflammation
Laboratory animals
Malaria
Mass spectroscopy
Medical research
Medicinal plants
Oleic acid
Palmitic acid
Paralysis
Parasites
Pharmacophores
Phenolic compounds
Phytochemicals
Plasmodium berghei
Raphia hookeri
Teaching hospitals
Tumors
Nigeria
Ibadan Nigeria
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Summary:Background of the study. Raphia hookeri G. Mann & H. Wendl (Arecaceae) is an important plant used in folkloric medicine to treat various ailments such as inflammation, tumor, microbial infections, paralysis, hypertension, and rheumatism, primarily in Africa and Asia. Aim and Objectives. The study was designed to investigate the antiplasmodial and antioxidant potencies of Raphia hookeri leaves, mesocarp, and epicarp using Plasmodium infected mice. The bioactive constituents were further explored via gas chromatography-mass spectrometry (GC-MS). Results. The presence of alkaloids, fats and oils, phenolic, and flavonoids was detected via the qualitative test which was confirmed from the result obtained from the GC-MS chromatogram of ethanolic leaves extract. The GC-MS chromatogram of the constituents analogous to the twenty peaks was analyzed as follows: dodecanoic acid (1.94%), 2-undecanone (3.42%), hexadecanoic acid (44.84%), oleic acid (7.45%), octadecanoic acid (8.41%), narcissidine (2.38%), 1-dotriacontanol (2.38%), α-sitosterol (2.02%), and lupeol (1.42%). The total phenolics and flavonoids of 118 and 23.3702 mg/g were analyzed in the leaves extract. The leave extract exhibited inhibitory activity of 73.49% against free radicals which could lead to inflammation. The extracts and chloroquine-treated groups showed significant decrease in percentage parasitaemia with pronounced activity observed in chloroquine groups. Conclusion. The curative and scavenging potencies of studied plant could be attributed to the metabolites analyzed and could guide the formulation of new pharmacophores against malaria infections and inflammations.
Bibliography:ObjectType-Article-1
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Academic Editor: Mohamed Z.M. Salem
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/4129045