Search Results - "Oguin, Thomas H."

Cold sensitivity of the SARS-CoV-2 spike ectodomain by Edwards, Robert J., Mansouri, Katayoun, Stalls, Victoria, Manne, Kartik, Watts, Brian, Parks, Rob, Janowska, Katarzyna, Gobeil, Sophie M. C., Kopp, Megan, Li, Dapeng, Lu, Xiaozhi, Mu, Zekun, Deyton, Margaret, Oguin, Thomas H., Sprenz, Jordan, Williams, Wilton, Saunders, Kevin O., Montefiori, David, Sempowski, Gregory D., Henderson, Rory, Munir Alam, S., Haynes, Barton F., Acharya, Priyamvada

“…The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its receptor binding domain in two conformations, the…”
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RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus by Nogusa, Shoko, Thapa, Roshan J., Dillon, Christopher P., Liedmann, Swantje, Oguin, Thomas H., Ingram, Justin P., Rodriguez, Diego A., Kosoff, Rachelle, Sharma, Shalini, Sturm, Oliver, Verbist, Katherine, Gough, Peter J., Bertin, John, Hartmann, Boris M., Sealfon, Stuart C., Kaiser, William J., Mocarski, Edward S., López, Carolina B., Thomas, Paul G., Oberst, Andrew, Green, Douglas R., Balachandran, Siddharth

“…Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We report that the kinase RIPK3 is essential for IAV-induced lysis…”
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Programmed Cell Death and Inflammation: Winter Is Coming by Kolb, Joseph P., Oguin, Thomas H., Oberst, Andrew, Martinez, Jennifer

“…The life of an organism requires the assistance of an unlikely process: programmed cell death. Both development and the maintenance of homeostasis result in…”
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SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation by Lederer, Katlyn, Castaño, Diana, Gómez Atria, Daniela, Oguin, Thomas H., Wang, Sidney, Manzoni, Tomaz B., Muramatsu, Hiromi, Hogan, Michael J., Amanat, Fatima, Cherubin, Patrick, Lundgreen, Kendall A., Tam, Ying K., Fan, Steven H.Y., Eisenlohr, Laurence C., Maillard, Ivan, Weissman, Drew, Bates, Paul, Krammer, Florian, Sempowski, Gregory D., Pardi, Norbert, Locci, Michela

“…The deployment of effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019…”
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A new class of antibodies that overcomes a steric barrier to cross-group neutralization of influenza viruses by Simmons, Holly C, Watanabe, Akiko, Oguin Iii, Thomas H, Van Itallie, Elizabeth S, Wiehe, Kevin J, Sempowski, Gregory D, Kuraoka, Masayuki, Kelsoe, Garnett, McCarthy, Kevin R

“…Antibody titers that inhibit the influenza virus hemagglutinin (HA) from engaging its receptor are the accepted correlate of protection from infection. Many…”
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Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+ T Cells by Rutigliano, John A, Sharma, Shalini, Morris, Melissa Y, Oguin, 3rd, Thomas H, McClaren, Jennifer L, Doherty, Peter C, Thomas, Paul G

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A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice by Laczkó, Dorottya, Hogan, Michael J., Toulmin, Sushila A., Hicks, Philip, Lederer, Katlyn, Gaudette, Brian T., Castaño, Diana, Amanat, Fatima, Muramatsu, Hiromi, Oguin, Thomas H., Ojha, Amrita, Zhang, Lizhou, Mu, Zekun, Parks, Robert, Manzoni, Tomaz B., Roper, Brianne, Strohmeier, Shirin, Tombácz, István, Arwood, Leslee, Nachbagauer, Raffael, Karikó, Katalin, Greenhouse, Jack, Pessaint, Laurent, Porto, Maciel, Putman-Taylor, Tammy, Strasbaugh, Amanda, Campbell, Tracey-Ann, Lin, Paulo J.C., Tam, Ying K., Sempowski, Gregory D., Farzan, Michael, Choe, Hyeryun, Saunders, Kevin O., Haynes, Barton F., Andersen, Hanne, Eisenlohr, Laurence C., Weissman, Drew, Krammer, Florian, Bates, Paul, Allman, David, Locci, Michela, Pardi, Norbert

“…SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high transmissibility of the virus and the high rate of morbidity and mortality…”
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Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease by Wong, Sing-Wai, Huang, Bo-Wen, Hu, Xiangxiang, Ho Kim, Eui, Kolb, Joseph P., Padilla, Ricardo J., Xue, Peng, Wang, Lufei, Oguin, Thomas H., Miguez, Patricia A., Tseng, Henry C., Ko, Ching-Chang, Martinez, Jennifer

“…Genome-wide association studies (GWAS) have identified Optineurin ( OPTN ) as genetically linked to Paget’s disease of the bone (PDB), a chronic debilitating…”
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Quantitative impact of thymic selection on Foxp3+ and Foxp3– subsets of self-peptide/MHC class II-specific CD4+ T cells by Moon, James J, Dash, Pradyot, Oguin, Thomas H. III, McClaren, Jennifer L, Chu, H. Hamlet, Thomas, Paul G, Jenkins, Marc K

“…It is currently thought that T cells with specificity for self-peptide/MHC (pMHC) ligands are deleted during thymic development, thereby preventing…”
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Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses by Saunders, Kevin O., Lee, Esther, Parks, Robert, Martinez, David R., Li, Dapeng, Chen, Haiyan, Edwards, Robert J., Gobeil, Sophie, Barr, Maggie, Mansouri, Katayoun, Alam, S. Munir, Sutherland, Laura L., Cai, Fangping, Sanzone, Aja M., Berry, Madison, Manne, Kartik, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Kapingidza, Anyway B., Azoitei, Mihai, Tse, Longping V., Scobey, Trevor D., Spreng, Rachel L., Rountree, R. Wes, DeMarco, C. Todd, Denny, Thomas N., Woods, Christopher W., Petzold, Elizabeth W., Tang, Juanjie, Oguin, Thomas H., Sempowski, Gregory D., Gagne, Matthew, Douek, Daniel C., Tomai, Mark A., Fox, Christopher B., Seder, Robert, Wiehe, Kevin, Weissman, Drew, Pardi, Norbert, Golding, Hana, Khurana, Surender, Acharya, Priyamvada, Andersen, Hanne, Lewis, Mark G., Moore, Ian N., Montefiori, David C., Baric, Ralph S., Haynes, Barton F.

“…Betacoronaviruses caused the outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, as well as the current pandemic of…”
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RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation by Daniels, Brian P., Snyder, Annelise G., Olsen, Tayla M., Orozco, Susana, Oguin, Thomas H., Tait, Stephen W.G., Martinez, Jennifer, Gale, Michael, Loo, Yueh-Ming, Oberst, Andrew

“…Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in…”
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Transient inhibition of lysosomal functions potentiates nucleic acid vaccines by Wang, Chunxi, Karlsson, Amelia, Oguin, 3rd, Thomas H, Macintyre, Andrew N, Sempowski, Gregory D, McCarthy, Kevin R, Wang, Yifei, Moody, M Anthony, Yuan, Fan

“…Nucleic acid vaccines have shown promising results in the clinic against infectious diseases and cancers. To robustly improve the vaccine efficacy and safety,…”
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Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization by Thornlow, Dana N, Macintyre, Andrew N, Oguin, Thomas H, Karlsson, Amelia B, Stover, Erica L, Lynch, Heather E, Sempowski, Gregory D, Schmidt, Aaron G

“…Influenza virus alters glycosylation patterns on its surface exposed glycoproteins to evade host adaptive immune responses. The viral hemagglutinin (HA), in…”
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Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine by Li, Dapeng, Martinez, David R., Schäfer, Alexandra, Chen, Haiyan, Barr, Maggie, Sutherland, Laura L., Lee, Esther, Parks, Robert, Mielke, Dieter, Edwards, Whitney, Newman, Amanda, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Gagne, Matthew, Douek, Daniel C., DeMarco, C. Todd, Denny, Thomas N., Oguin, Thomas H., Brown, Alecia, Rountree, Wes, Wang, Yunfei, Mansouri, Katayoun, Edwards, Robert J., Ferrari, Guido, Sempowski, Gregory D., Eaton, Amanda, Tang, Juanjie, Cain, Derek W., Santra, Sampa, Pardi, Norbert, Weissman, Drew, Tomai, Mark A., Fox, Christopher B., Moore, Ian N., Andersen, Hanne, Lewis, Mark G., Golding, Hana, Seder, Robert, Khurana, Surender, Baric, Ralph S., Montefiori, David C., Saunders, Kevin O., Haynes, Barton F.

“…Coronavirus vaccines that are highly effective against current and anticipated SARS-CoV-2 variants are needed to control COVID-19. We previously reported a…”
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Paired analysis of TCRα and TCRβ chains at the single-cell level in mice by Dash, Pradyot, McClaren, Jennifer L, Oguin, 3rd, Thomas H, Rothwell, William, Todd, Brandon, Morris, Melissa Y, Becksfort, Jared, Reynolds, Cory, Brown, Scott A, Doherty, Peter C, Thomas, Paul G

“…Characterizing the TCRα and TCRβ chains expressed by T cells responding to a given pathogen or underlying autoimmunity helps in the development of vaccines and…”
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Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease by Wong, Sing-Wai, Huang, Bo-Wen, Hu, Xiangxiang, Kim, Eui Ho, Kolb, Joseph P., Padilla, Ricardo J., Xue, Peng, Wang, Lufei, Oguin, Thomas H., Miguez, Patricia A., Tseng, Henry C., Ko, Ching-Chang, Martinez, Jennifer

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Enhanced Susceptibility of Ago1/3 Double-Null Mice to Influenza A Virus Infection by Van Stry, Melanie, Oguin, 3rd, Thomas H, Cheloufi, Sihem, Vogel, Peter, Watanabe, Makiko, Pillai, Meenu R, Dash, Pradyot, Thomas, Paul G, Hannon, Gregory J, Bix, Mark

“…Author's Correction ( vol. 86 , p. 8344 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Gut check: dead cell samples leads to tolerant examples by Oguin, Thomas H, Martinez, Jennifer

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Phospholipase D Facilitates Efficient Entry of Influenza Virus, Allowing Escape from Innate Immune Inhibition by Oguin, Thomas H., Sharma, Shalini, Stuart, Amanda D., Duan, Susu, Scott, Sarah A., Jones, Carrie K., Daniels, J. Scott, Lindsley, Craig W., Thomas, Paul G., Brown, H. Alex

“…Lipid metabolism plays a fundamental role during influenza virus replication, although key regulators of lipid-dependent trafficking and virus production…”
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Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing by Van de Velde, Lee-Ann, Guo, Xi-Zhi J., Barbaric, Lidija, Smith, Amber M., Oguin, Thomas H., Thomas, Paul G., Murray, Peter J.

“…GCN2 is one of four “stress kinases” that block translation by phosphorylating eIF2α. GCN2 is thought to bind uncharged tRNAs to “sense” amino acid…”
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