Urinary CXCL9 and CXCL10 Levels and Acute Renal Graft Rejection

Urinary CXCL9 and CXCL10 Levels and Acute Renal Graft Rejection

Monitoring of chemokines, CXCL9 and CXCL10, in serum may present a non-invasive detection method for rejection. To investigate the relationship between urinary levels of CXCL9 and CXCL10 and graft function following renal transplantation. 75 living-related donor renal transplant recipients were stud...

Full description

Saved in:
Bibliographic Details
Published in:International journal of organ transplantation medicine Vol. 10; no. 2; pp. 53 - 63
Main Authors: Ciftci, H S, Tefik, T, Savran, M K, Demir, E, Caliskan, Y, Ogret, Y D, Oktar, T, Sanlı, O, Kocak, T, Ozluk, Y, Oguz, F S, Kilicaslan, I, Aydın, F, Turkmen, A, Nane, I
Format: Journal Article
Language:English
Published: Iran Shiraz University of Medical Sciences 01-01-2019
Avicenna Organ Transplantation Institute
Subjects:
Biomarker
Biomarkers
Cell adhesion & migration
Chemokines
Cytokines
Cytotoxicity
Gene expression
Graft function
Kidney diseases
Ligands
Lymphocytes
Original
Proteins
Rejection
Renal transplantation
Studies
Transplants & implants
Urine
Rejection
Renal transplantation
Biomarker
Graft function
Chemokines
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Monitoring of chemokines, CXCL9 and CXCL10, in serum may present a non-invasive detection method for rejection. To investigate the relationship between urinary levels of CXCL9 and CXCL10 and graft function following renal transplantation. 75 living-related donor renal transplant recipients were studied. Urinary levels of chemokines were collected pre-operatively, on post-operative 1 day, 7 day, 1 month, 3 month, and at the time of rejection. Chemokines levels were assayed using and enzyme-linked immunosorbent assay. Clinical variables were monitored. 10 (15%) patients had biopsy-proven rejection during the follow-up period. The urinary CXCL9 level in those with rejection was significantly higher than that in those with non-rejection group at the 1 day (p<0.001), 7 day (p<0.001), and at the time of rejection (p=0.002). The urinary CXCL10 level was also significantly higher in those with rejection compared with non-rejection group at 1 day (p<0.001), 7 day (p<0.001), and at the time of rejection (p=0.001). Serum creatinine level was strongly correlated with the urinary CXCL9 and CXCL10 levels at the time of rejection (r=0.615, p=0.002; and r=0.519, p=0.022, respectively). Among those with T cell-mediated rejections the mean urinary CXCL10 level increased to as high as 258.12 ng/mL. Urinary CXCL9 and CXCL10 levels might have a predictive value for T cell-mediated rejection in early post-transplantation period. Measurement of urinary CXCL9 and CXCL10 levels could provide an additional tool for the diagnosis of rejection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2008-6482
2008-6490