Search Results - "Ognjenovic, Nevena B"
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Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits
Published in Breast cancer research : BCR (01-03-2023)“…Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these subtypes…”
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Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer
Published in Science advances (05-08-2022)“…The epithelial-to-mesenchymal transition (EMT) is frequently co-opted by cancer cells to enhance migratory and invasive cell traits. It is a key contributor to…”
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Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors
Published in Developmental cell (07-12-2020)“…Differentiation therapy utilizes our understanding of the hierarchy of cellular systems to pharmacologically induce a shift toward terminal commitment. While…”
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Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer
Published in Cell reports. Medicine (16-04-2024)“…Targeted therapies have improved outcomes for certain cancer subtypes, but cytotoxic chemotherapy remains a mainstay for triple-negative breast cancer (TNBC)…”
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Abstract 6430: Redefining therapy regimens for triple negative breast cancer - Exploiting the epigenetic effects of eribulin action
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Abstract While the advent of targeted therapy has led to vast improvements in outcomes for certain types of breast cancer, the standard of care for triple…”
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Abstract P3-06-01: Eribulin alters the chromatin landscape to induce MET, attenuating metastatic progression and sensitizing breast tumors to subsequent chemotherapy
Published in Cancer research (Chicago, Ill.) (15-02-2022)“…Abstract Introduction: Two major hurdles faced in clinical cancer therapy are metastatic progression that results in the majority of cancer deaths, and…”
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Abstract 6251: Validation and implementation of whole-transcriptome sequencing assay into cancer care: An experience from a cancer center
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Introduction Transcriptome sequencing is a well-established diagnostic tool to characterize and quantify gene expression profiles and to detect fusion…”
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Abstract 1602: Lineage plasticity enables low ER luminal tumors to evolve and gain basal-like traits
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Stratifying breast cancer into specific molecular or histological subtypes aids in therapeutic decision-making and predicting outcomes, however, these…”
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Abstract 1785: Eribulin alters the chromatin landscape to induce MET, attenuating metastatic progression sensitizing breast tumors to subsequent chemotherapy
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Introduction: Two major hurdles faced in clinical cancer therapy are metastatic progression that results in the majority of cancer deaths, and…”
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