Search Results - "Ogmundsdottir, Helga Margret"

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth by Di Malta, Chiara, Siciliano, Diletta, Calcagni, Alessia, Monfregola, Jlenia, Punzi, Simona, Pastore, Nunzia, Eastes, Andrea N., Davis, Oliver, De Cegli, Rossella, Zampelli, Angela, Di Giovannantonio, Luca G., Nusco, Edoardo, Platt, Nick, Guida, Alessandro, Ogmundsdottir, Margret Helga, Lanfrancone, Luisa, Perera, Rushika M., Zoncu, Roberto, Pelicci, Pier Giuseppe, Settembre, Carmine, Ballabio, Andrea

“…The mechanistic target of rapamycin complex 1 (mTORC1) is recruited to the lysosome by Rag guanosine triphosphatases (GTPases) and regulates anabolic pathways…”
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Lipidomic study of cell lines reveals differences between breast cancer subtypes by Eiriksson, Finnur Freyr, Nøhr, Martha Kampp, Costa, Margarida, Bödvarsdottir, Sigridur Klara, Ögmundsdottir, Helga Margret, Thorsteinsdottir, Margret

“…Breast cancer (BC) is the most prevalent type of cancer in women in western countries. BC mortality has not declined despite early detection by screening,…”
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The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells by Myszor, Iwona T., Sigurdsson, Snaevar, Viktorsdottir, Alexia Ros, Agerberth, Birgitta, Eskelinen, Eeva-Liisa, Ogmundsdottir, Margret Helga, Gudmundsson, Gudmundur H.

“…Aroylated phenylenediamines (APDs) are novel modulators of innate immunity with respect to enhancing the expression of antimicrobial peptides and maintaining…”
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Abstract 4108: The lichen compound usnic acid disturbs mitochondrial and lysosomal function by proton shuttling by Bessadottir, Margret, Ogmundsdottir, Margret Helga, Egilsson, Mar, Einarsdottir, Eydis, Omarsdottir, Sesselja, Ogmundsdottir, Helga Margret

“…Differential intracellular pH plays an important role in organelle function and intracellular transport. The intracellular distribution of cancer drugs is also…”
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MITF and TFEB cross-regulation in melanoma cells by Ballesteros-Álvarez, Josué, Dilshat, Ramile, Fock, Valerie, Möller, Katrín, Karl, Ludwig, Larue, Lionel, Ögmundsdóttir, Margrét Helga, Steingrímsson, Eiríkur

“…The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to the basic helix-loop-helix family of leucine zipper transcription factors. MITF is crucial for…”
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MITF reprograms the extracellular matrix and focal adhesion in melanoma by Dilshat, Ramile, Fock, Valerie, Kenny, Colin, Gerritsen, Ilse, Lasseur, Romain Maurice Jacques, Travnickova, Jana, Eichhoff, Ossia M, Cerny, Philipp, Möller, Katrin, Sigurbjörnsdóttir, Sara, Kirty, Kritika, Einarsdottir, Berglind Ósk, Cheng, Phil F, Levesque, Mitchell, Cornell, Robert A, Patton, E Elizabeth, Larue, Lionel, de Tayrac, Marie, Magnúsdóttir, Erna, Ögmundsdóttir, Margrét Helga, Steingrimsson, Eirikur

“…The microphthalmia-associated transcription factor (MITF) is a critical regulator of melanocyte development and differentiation. It also plays an important…”
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A novel region within a conserved domain in ATG7 emerged in vertebrates by Hjaltalin, Valgerdur J., Pogenberg, Vivian, Ostacolo, Kevin, Pálsson, Arnar, Ogmundsdottir, Margrét Helga

“…The E1-like enzyme ATG7 belongs to a group of ATG proteins that mediate the autophagy process. Autophagy is a highly conserved degradation pathway important…”
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Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1 by Zhang, Tianyi, Zhou, Qingxiang, Ogmundsdottir, Margret Helga, Möller, Katrin, Siddaway, Robert, Larue, Lionel, Hsing, Michael, Kong, Sek Won, Goding, Colin Ronald, Palsson, Arnar, Steingrimsson, Eirikur, Pignoni, Francesca

“…The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well…”
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NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease by Bindesbøll, Christian, Aas, Aleksander, Ogmundsdottir, Margret Helga, Pankiv, Serhiy, Reine, Trine, Zoncu, Roberto, Simonsen, Anne

“…Dysregulated cholesterol homeostasis promotes the pathology of atherosclerosis, myocardial infarction and strokes. Cellular cholesterol is mainly regulated at…”
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The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function by García-Llorca, Andrea, Aspelund, Snaefridur Gudmundsdottir, Ogmundsdottir, Margret Helga, Steingrimsson, Eiríkur, Eysteinsson, Thor

“…Mutations in the microphthalmia-associated transcription factor ( Mitf ) gene can cause retinal pigment epithelium (RPE) and retinal dysfunction and…”
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Subcellular localization and stability of MITF are modulated by the bHLH‐Zip domain by Fock, Valerie, Gudmundsson, Sigurdur Runar, Gunnlaugsson, Hilmar Orn, Stefansson, Jon August, Ionasz, Vivien, Schepsky, Alexander, Viarigi, Jade, Reynisson, Indridi Einar, Pogenberg, Vivian, Wilmanns, Matthias, Ogmundsdottir, Margret Helga, Steingrimsson, Eirikur

“…Summary Microphthalmia‐associated transcription factor (MITF) is a member of the basic helix–loop–helix leucine zipper (bHLH‐Zip) family and functions as the…”
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Abstract 311: Autophagic pathways and activity in breast and pancreatic cancer by Egilsson, Mar, Thoroddsen, Ulfur, Jonasson, Jon Gunnlaugur, Ogmundsdottir, Margret Helga, Ögmundsdottir, Helga M.

“…Autophagy is induced as a homeostatic process by energy shortage and cellular stress but can also be influenced by drugs. Poor autophagic function contributes…”
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The Nobel Prize in Medicine emphasizes the importance of recycling[Editorial by Ogmundsdottir, Margret Helga

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Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif by Pogenberg, Vivian, Ballesteros-Álvarez, Josué, Schober, Romana, Sigvaldadóttir, Ingibjörg, Obarska-Kosinska, Agnieszka, Milewski, Morlin, Schindl, Rainer, Ögmundsdóttir, Margrét Helga, Steingrímsson, Eiríkur, Wilmanns, Matthias

“…Abstract Interrupted dimeric coiled coil segments are found in a broad range of proteins and generally confer selective functional properties such as binding…”
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Sensitivity of BRCA2 mutated human cell lines to Aurora kinase inhibition by Vidarsdottir, Linda, Steingrimsdottir, Gudridur, Bodvarsdottir, Sigridur Klara, Ogmundsdottir, Helga Margret, Eyfjord, Jorunn Erla

“…Summary Aurora kinases play a vital part in successful mitosis and cell division. Aberrant Aurora-A and -B expression is commonly seen in various types of…”
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A conditional Mitf mouse model of geographic atrophy (GA) by García Llorca, Andrea, Sabaté, Alba, Ögmundsdóttir, Margrét Helga, Larue, Lionel, Gesbert, Franck, Steingrímsson, Eiríkur, Eysteinsson, Thor

“…Purpose Mice carrying different mutations in the microphthalmia‐associated transcription factor (Mitf) gene, affect the normal the retinal pigment epithelium…”
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Different rate of retinal degenerations in mice with two distinct mutations in the Mitf gene by Eysteinsson, Thor, Jónasdóttir, Ingunn, García‐Llorca, Andrea, Björg Gudmundsdóttir, Thorunn, Ögmundsdóttir, Margrét Helga, Steingrímsson, Eiríkur

“…Purpose The microphthalmia‐associated transcription factor (Mitf) gene is crucial for development of the retinal pigment epithelium (RPE) and photoreceptors…”
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Nóbelsverðlaunin í læknavísindum í ár endurspegla mikilvægi sorphirðu og endurvinnslu by Ögmundsdóttir, Margrét Helga

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Non-specific recognition by macrophages and mechanisms of macrophage activation by Ögmundsdóttir, Helga Margret

“…This study deals with two related aspects of macrophage function, surface recognition and signal transmission across the plasma membrane. The introduction…”
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