Search Results - "Ogi, Sayaka"

Sorting nexin 2‐mediated membrane trafficking of c‐Met contributes to sensitivity of molecular‐targeted drugs by Ogi, Sayaka, Fujita, Hideaki, Kashihara, Masaki, Yamamoto, Chizuko, Sonoda, Kahori, Okamoto, Isamu, Nakagawa, Kazuhiko, Ohdo, Shigehiro, Tanaka, Yoshitaka, Kuwano, Michihiko, Ono, Mayumi

“…The sorting nexin (SNX) family is a diverse group of cytoplasmic and membrane‐associated proteins that are involved in membrane‐trafficking steps within the…”
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Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model by Kaseda, Shota, Sannomiya, Yuya, Horizono, Jun, Kuwazuru, Jun, Suico, Mary Ann, Ogi, Sayaka, Sasaki, Ryoko, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nishiyama, Hayato, Kamura, Misato, Niinou, Saki, Koyama, Yuimi, Nara, Futoshi, Shuto, Tsuyoshi, Onuma, Kazuhiro, Kai, Hirofumi

“…Background Bardoxolone methyl activates nuclear factor erythroid 2–related factor 2 (Nrf2) via covalent binding and irreversible inhibition of Kelch-like…”
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Efficacy of Keap1-Nrf2 protein-protein interaction inhibitor for progressive phenotype in Alport syndrome mouse model by Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Yuimi Koyama, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai

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MO578: UBE-1099, A Novel Non-Covalent Keap1-NRF2 Inhibitor, Protects Against Renal Ischemia-Reperfusion Injury by Ogi, Sayaka, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nara, Futoshi, Onuma, Kazuhiro

“…Abstract BACKGROUND AND AIMS Bardoxolone methyl is a covalent Kelch-like ECH-associated protein 1 (Keap1) inhibitor that induces nuclear factor erythroid…”
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UBE-1099, a Novel Non-Covalent Keap1-Nrf2 Inhibitor, Protects Against Renal Ischemia-Reperfusion Injury via Nrf2 Activation: PO2508 by Ogi, Sayaka, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nara, Futoshi, Onuma, Kazuhiro

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Bardoxolone methyl prevents metabolic dysfunction‐associated steatohepatitis by inhibiting macrophage infiltration by Onuma, Kazuhiro, Watanabe, Kenji, Isayama, Keishiro, Ogi, Sayaka, Tokunaga, Yasunori, Mizukami, Yoichi

“…Background and Purpose Bardoxolone methyl (2‐cyano‐3,12‐dioxooleana‐1,9(11)‐dien‐28‐oic acid methyl ester, CDDO‐Me) is a potent activator of nuclear factor…”
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Novel Keap-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates the Severity of Experimental Alport Syndrome: PO1302 by Kaseda, Shota, Suico, Mary Ann, Ogi, Sayaka, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nara, Futoshi, Shuto, Tsuyoshi, Onuma, Kazuhiro, Kai, Hirofumi

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Preclinical in vitro and in vivo study of UD-017, a novel highly selective and orally available CDK7 inhibitor, in a variety of cancers by Onuma, Kazuhiro, Aga, Yasuhiro, Ogi, Sayaka, Matsushita, Takashi, Sunamoto, Hidetoshi, Ogawa, Ayumi, Tokunaga, Yasunori, Ushiyama, Shigeru

“…Abstract only e14086 Background: Cyclin dependent kinase 7 (CDK7) modulates mRNA transcription and some oncogenes are reported to be sensitive to inhibition of…”
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Abstract 4835: UD-017, a novel highly selective and orally active CDK7 inhibitor, shows a significant anticancer activity in patient-derived cancers by Matsushita, Takashi, Ogi, Sayaka, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Ogawa, Ayumi, Hasegawa, Toru, Tokunaga, Yasunori, Aga, Yasuhiro, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for anticancer drugs due to its dual roles, cell cycle regulation and gene…”
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Abstract 4837: Evaluation of anticancer activities of UD-017, a novel selective and orally available CDK7 inhibitor, in blood cancers by Aga, Yasuhiro, Ogi, Sayaka, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Matsushita, Takashi, Ogawa, Ayumi, Hasegawa, toru, Kono, Shigeyuki, Iwase, Noriaki, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for anticancer drugs due to its dual roles, cell cycle regulation and gene…”
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Abstract LB-111: In vitro anti-cancer activity of UD-017, a novel potent & highly selective CDK7 reversible inhibitor by Matsushita, Takashi, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Ogawa, Ayumi, Ogi, Sayaka, Hasegawa, Toru, Kono, Shigeyuki, Iwase, Noriaki, Aga, Yasuhiro, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is a member of the CDK family, & has a dual function relating to the cell cycle progression & gene…”
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Abstract LB-297: In vivo anti-tumor efficacy of UD-017, a novel highly selective & orally available CDK7 inhibitor, in colorectal cancer cells xenograft models by Aga, Yasuhiro, Ogi, Sayaka, Tokunaga, Yasunori, Ogawa, Ayumi, Onuma, Kazuhiro, Matsushita, Takashi, Sunamoto, Hidetoshi, Hasegawa, Toru, Ushiyama, Shigeru

“…Abstract Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for cancer drugs due to its dual roles, cell cycle regulation & gene…”
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Preclinical in vitro and in vivo evaluation of antitumor activity of UD-017, a novel selective and orally available CDK7 inhibitor, in colorectal cancer by Ogi, Sayaka, Aga, Yasuhiro, Onuma, Kazuhiro, Sunamoto, Hidetoshi, Matsushita, Takashi, Ogawa, Ayumi, Hasegawa, Tohru, Kono, Shigeyuki, Iwase, Noriaki, Tokunaga, Yasunori, Ushiyama, Shigeru

“…Abstract only e14085 Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for cancer drugs due to its dual roles, cell cycle regulation and…”
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Abstract 1199: Sorting nexin 2 (SNX2) controls drug sensitivity to molecular targeted anticancer agents through membrane trafficking of c-Met protein in cancer cell by Ono, Mayumi, Ogi, Sayaka, Yamamoto, Chizuko, Fujita, Hideaki, Kuwano, Michihiko

“…Abstract Various molecular targeted anticancer drugs are often developed by targeting activated growth factor receptors that are expressed on plasma membrane…”
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Sorting nexin 2‐mediated membrane trafficking of c‐ M et contributes to sensitivity of molecular‐targeted drugs by Ogi, Sayaka, Fujita, Hideaki, Kashihara, Masaki, Yamamoto, Chizuko, Sonoda, Kahori, Okamoto, Isamu, Nakagawa, Kazuhiko, Ohdo, Shigehiro, Tanaka, Yoshitaka, Kuwano, Michihiko, Ono, Mayumi

“…The sorting nexin ( SNX ) family is a diverse group of cytoplasmic and membrane‐associated proteins that are involved in membrane‐trafficking steps within the…”
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