Search Results - "Ogden, R Todd"

Likelihood estimation of drug occupancy for brain PET studies by Schain, Martin, Zanderigo, Francesca, Todd Ogden, R.

“…Neuroimaging with PET is unique in its capability to measure in vivo the occupancy of a drug. The occupancy is typically obtained by conducting PET…”
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Simultaneous multifactor Bayesian analysis (SiMBA) of PET time activity curve data by Matheson, Granville J., Ogden, R. Todd

“…•SiMBA is a pharmacokinetic modelling approach for Positron Emission Tomography data.•It is a multivariate hierarchical implementation of the two-tissue…”
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Multiple Domain and Multiple Kernel Outcome-Weighted Learning for Estimating Individualized Treatment Regimes by Xie, Shanghong, Tarpey, Thaddeus, Petkova, Eva, Todd Ogden, R.

“…Individualized treatment rules (ITRs) recommend treatments that are tailored specifically according to each patient's own characteristics. It can be…”
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Smoothing parameter selection for a class of semiparametric linear models by Reiss, Philip T, Todd Ogden, R

“…Spline-based approaches to non-parametric and semiparametric regression, as well as to regression of scalar outcomes on functional predictors, entail choosing…”
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Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network by Vincent, Amy E., White, Kathryn, Davey, Tracey, Philips, Jonathan, Ogden, R. Todd, Lawless, Conor, Warren, Charlotte, Hall, Matt G., Ng, Yi Shiau, Falkous, Gavin, Holden, Thomas, Deehan, David, Taylor, Robert W., Turnbull, Doug M., Picard, Martin

“…Genetic and biochemical defects of mitochondrial function are a major cause of human disease, but their link to mitochondrial morphology in situ has not been…”
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Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period by Canetta, Sarah E, Holt, Emma S, Benoit, Laura J, Teboul, Eric, Sahyoun, Gabriella M, Ogden, R Todd, Harris, Alexander Z, Kellendonk, Christoph

“…In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and…”
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Source‐to‐Target Automatic Rotating Estimation (STARE) – A publicly‐available, blood‐free quantification approach for PET tracers with irreversible kinetics: Theoretical framework and validation for [18F]FDG by Bartlett, Elizabeth A, Ogden, R Todd, Mann, J John, Zanderigo, Francesca

“…Full quantification of positron emission tomography (PET) data requires an input function. This generally means arterial blood sampling, which is invasive,…”
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Quantitative mapping of human hair greying and reversal in relation to life stress by Rosenberg, Ayelet M, Rausser, Shannon, Ren, Junting, Mosharov, Eugene V, Sturm, Gabriel, Ogden, R Todd, Patel, Purvi, Kumar Soni, Rajesh, Lacefield, Clay, Tobin, Desmond J, Paus, Ralf, Picard, Martin

“…Background: Hair greying is a hallmark of aging generally believed to be irreversible and linked to psychological stress. Methods: Here, we develop an approach…”
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Resting State MRI Amplitude of Low Frequency Fluctuations Associated With Suicidal Ideation in Bipolar Depression by Lan, Martin J, Pantazatos, Spiro P, Ogden, R Todd, Rubin-Falcone, Harry, Hellerstein, David, McGrath, Patrick J, Mann, J John

“…Suicidal ideation (SI) is a risk factor for completed suicide. Our previous resting state functional magnetic resonance imaging (fMRI) study found that higher…”
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Treatment decisions based on scalar and functional baseline covariates by Ciarleglio, Adam, Petkova, Eva, Ogden, R. Todd, Tarpey, Thaddeus

“…The amount and complexity of patient‐level data being collected in randomized‐controlled trials offer both opportunities and challenges for developing…”
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Model-Free Quantification of Dynamic PET Data Using Nonparametric Deconvolution by Zanderigo, Francesca, Parsey, Ramin V, Ogden, R Todd

“…Dynamic positron emission tomography (PET) data are usually quantified using compartment models (CMs) or derived graphical approaches. Often, however, CMs…”
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Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors by Bindra, Snehal, McGill, Marlon A., Triplett, Marina K., Tyagi, Anisha, Thaker, Premal H., Dahmoush, Laila, Goodheart, Michael J., Ogden, R. Todd, Owusu-Ansah, Edward, R Karan, Kalpita, Cole, Steve, Sood, Anil K., Lutgendorf, Susan K., Picard, Martin

“…Malignant tumor cells exhibit mitochondrial alterations and are also influenced by biobehavioral processes, but the intersection of biobehavioral factors and…”
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Brain Serotonin 1A Receptor Binding as a Predictor of Treatment Outcome in Major Depressive Disorder by Miller, Jeffrey M, Hesselgrave, Natalie, Ogden, R. Todd, Zanderigo, Francesca, Oquendo, Maria A, Mann, J. John, Parsey, Ramin V

“…Background We previously reported higher serotonin 1A receptor (5-HT1A) binding in subjects with major depressive disorder (MDD) during a major depressive…”
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Designing drug occupancy studies with PET neuroimaging: Sample size, occupancy ranges and analytical methods by Laurell, Gjertrud Louise, Plavén-Sigray, Pontus, Svarer, Claus, Ogden, R. Todd, Knudsen, Gitte Moos, Schain, Martin

“…•Likelihood-based approaches yield considerably better VT-based IC50 estimates than those derived from the Lassen plot.•We see very limited benefit in scanning…”
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Quantification of the Serotonin 1A Receptor Using PET: Identification of a Potential Biomarker of Major Depression in Males by Kaufman, Joshua, Sullivan, Gregory M, Yang, Jie, Ogden, R Todd, Miller, Jeffrey M, Oquendo, Maria A, Mann, J John, Parsey, Ramin V, DeLorenzo, Christine

“…Multiple lines of research have implicated the serotonin 1A (5-HT1A) receptor in major depressive disorder (MDD). Despite this, quantification of 5-HT1A is yet…”
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Estimation of in vivo nonspecific binding in positron emission tomography studies without requiring a reference region by Todd Ogden, R., Zanderigo, Francesca, Parsey, Ramin V.

“…Estimation of outcome measures in in vivo neuroreceptor mapping with positron emission tomography (PET) commonly depends on an assumption of uniform…”
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In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB by DeLorenzo, Christine, Gallezot, Jean-Dominique, Gardus, John, Yang, Jie, Planeta, Beata, Nabulsi, Nabeel, Ogden, R Todd, Labaree, David C, Huang, Yiyun H, Mann, J John, Gasparini, Fabrizio, Lin, Xin, Javitch, Jonathan A, Parsey, Ramin V, Carson, Richard E, Esterlis, Irina

“…Positron emission tomography tracers [11C]ABP688 and [18F]FPEB target the metabotropic glutamate receptor subtype 5 providing quantification of the brain…”
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Serotonin 1A Receptor Binding of [11C]CUMI-101 in Bipolar Depression Quantified Using Positron Emission Tomography: Relationship to Psychopathology and Antidepressant Response by Lan, Martin J, Zanderigo, Francesca, Pantazatos, Spiro P, Sublette, M Elizabeth, Miller, Jeffrey, Ogden, R Todd, Mann, J John

“…Abstract Background The pathophysiology of bipolar disorder (BD) remains largely unknown despite it causing significant disability and suicide risk. Serotonin…”
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A hybrid deconvolution approach for estimation of in vivo non-displaceable binding for brain PET targets without a reference region by Zanderigo, Francesca, Mann, J John, Ogden, R Todd

“…Estimation of a PET tracer's non-displaceable distribution volume (VND) is required for quantification of specific binding to its target of interest. VND is…”
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Higher Serotonin 1A Binding in a Second Major Depression Cohort: Modeling and Reference Region Considerations by Parsey, Ramin V, Ogden, R. Todd, Miller, Jeffrey M, Tin, Adrienne, Hesselgrave, Natalie, Goldstein, Ellen, Mikhno, Arthur, Milak, Matthew, Zanderigo, Francesca, Sullivan, Gregory M, Oquendo, Maria A, Mann, J. John

“…Background Serotonin 1A receptors (5-HT1A ) are implicated in major depressive disorder (MDD). We previously reported higher 5-HT1A binding potential (BPF ) in…”
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