Search Results - "Ogburn, Evan T."

Efavirenz Primary and Secondary Metabolism In Vitro and In Vivo: Identification of Novel Metabolic Pathways and Cytochrome P450 2A6 as the Principal Catalyst of Efavirenz 7-Hydroxylation by OGBURN, Evan T, JONES, David R, MASTERS, Andrea R, CONG XU, YINGYING GUO, DESTA, Zeruesenay

“…Efavirenz primary and secondary metabolism was investigated in vitro and in vivo. In human liver microsome (HLM) samples, 7- and 8-hydroxyefavirenz accounted…”
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Genotype-Guided Tamoxifen Dosing Increases Active Metabolite Exposure in Women With Reduced CYP2D6 Metabolism: A Multicenter Study by IRVIN, William J, WALKO, Christine M, RAAB, Rachel E, CORSO, Steven W, PEPPERCORN, Jeffrey M, ANDERSON, Steven M, FRIEDMAN, Kenneth J, OGBURN, Evan T, DESTA, Zeruesenay, FLOCKHART, David A, MCLEOD, Howard L, EVANS, James P, WECK, Karen E, CAREY, Lisa A, IBRAHIM, Joseph G, CHIU, WingK, DEES, E. Claire, MOORE, Susan G, OLAJIDE, Oludamilola A, GRAHAM, Mark L, CANALE, Sean T

“…We examined the feasibility of using CYP2D6 genotyping to determine optimal tamoxifen dose and investigated whether the key active tamoxifen metabolite,…”
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Contribution of N-Glucuronidation to Efavirenz Elimination In Vivo in the Basal and Rifampin-Induced Metabolism of Efavirenz by CHO, Doo-Yeoun, OGBURN, Evan T, JONES, David, DESTA, Zeruesenay

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Effects of the CYP2B66 allele on catalytic properties and inhibition of CYP2B6 in vitro: implication for the mechanism of reduced efavirenz metabolism and other CYP2B6 substrates in vivo by Xu, Cong, Ogburn, Evan T, Guo, Yingying, Desta, Zeruesenay

“…The mechanism by which CYP2B6*6 allele alters drug metabolism in vitro and in vivo is not fully understood. To test the hypothesis that altered substrate…”
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Stereoselective and regiospecific hydroxylation of ketamine and norketamine by Desta, Zeruesenay, Moaddel, Ruin, Ogburn, Evan T., Xu, Cong, Ramamoorthy, Anuradha, Venkata, Swarajya Lakshmi Vattem, Sanghvi, Mitesh, Goldberg, Michael E., Torjman, Marc C., Wainer, Irving W.

“…The objective was to determine the cytochrome P450s (CYPs) responsible for the stereoselective and regiospecific hydroxylation of ketamine [(R,S)-Ket] to…”
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Microfabricated Electrochemical Detector for High-Performance Liquid Chromatography by Ogburn, Evan T, Dziewatkoski, Michael, Moles, Don, Johnson, Jay M, Heineman, William R

“…A microfabricated electrochemical cell has been developed as a disposable detector for flow injection analysis (FIA) and high-performance liquid chromatography…”
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CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer by Love, Richard R, Desta, Zuerenesay, Flockhart, David, Skaar, Todd, Ogburn, Evan T, Ramamoorthy, Anuradha, Uy, Gemma B, Laudico, Adriano V, Van Dinh, Nguyen, Quang, Le Hong, Van To, Ta, Young, Gregory S, Hade, Erinn, Jarjoura, David

“…Background While tamoxifen activity is mainly due to endoxifen and the concentration of this active metabolite is, in part, controlled by CYP2D6 metabolic…”
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Effects of the CYP2B6 6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo by Xu, Cong, Ogburn, Evan T., Guo, Yingying, Desta, Zeruesenay

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CYP2D6 genotypes, endoxifen levels, and disease recurrence in 224 Filipino and Vietnamese women receiving adjuvant tamoxifen for operable breast cancer by Love, Richard R, Desta, Zuerenesay, Flockhart, David, Skaar, Todd, Ogburn, Evan T, Ramamoorthy, Anuradha, Uy, Gemma B, Laudico, Adriano V, Van Dinh, Nguyen, Quang, Le Hong, Van To, Ta, Young, Gregory S, Hade, Erinn, Jarjoura, David

“…BACKGROUNDWhile tamoxifen activity is mainly due to endoxifen and the concentration of this active metabolite is, in part, controlled by CYP2D6 metabolic…”
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