In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine

In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine

Twenty plants identified and selected from Southwest and Middle belt Nigerian antimalarial ethnopharmacology were evaluated for in vitro cytotoxicity using the brine shrimp lethality assay. The methanol extracts of 20 plant samples from 11 plant families were subjected to the assay. Of the studied p...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) Vol. 13; no. 4; pp. 295 - 298
Main Authors: Ajaiyeoba, E.O., Abiodun, O.O., Falade, M.O., Ogbole, N.O., Ashidi, J.S., Happi, C.T., Akinboye, D.O.
Format: Journal Article
Language:English
Published: Germany Elsevier GmbH 01-03-2006
Urban & Fischer Verlag
Subjects:
Animals
Antimalarial ethnomedicine
Antimalarials
Antimalarials - toxicity
Artemia - drug effects
Cytotoxicity
Drug therapy
Lethal Dose 50
Malaria
Medicine, African Traditional
Methanol - chemistry
Nigeria
Plant Extracts - toxicity
Plants
Plants, Medicinal - chemistry
Plants, Medicinal - toxicity
Toxicity Tests
Nigeria
United States
Cytotoxicity
Plants
Nigeria
Antimalarial ethnomedicine
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Summary:Twenty plants identified and selected from Southwest and Middle belt Nigerian antimalarial ethnopharmacology were evaluated for in vitro cytotoxicity using the brine shrimp lethality assay. The methanol extracts of 20 plant samples from 11 plant families were subjected to the assay. Of the studied plants, Lippia multiflora and Morinda lucida bark were found to be cytotoxic, with LC 50 values of 1.1 and 2.6 μg/ml, respectively. The least toxic plant extract was Bridelia micrantha (LC 50 value >9.0×10 6 μg/ml). Most of the plants were found to be relatively non-toxic.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2005.01.015