Asymptomatic malaria parasitemia does not induce additional oxidative stress in pregnant women of South East Nigeria

Asymptomatic malaria parasitemia does not induce additional oxidative stress in pregnant women of South East Nigeria

To determine the relationship between asymptomatic malaria parasitemia and some oxidative stress parameters in pregnant Nigerian women. This is a cross-sectional study involving 130 normal pregnant women at various trimesters, who were attending antenatal clinic at the University of Nigeria Teaching...

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Bibliographic Details
Published in:Asian Pacific journal of tropical medicine Vol. 4; no. 3; p. 229
Main Authors: Nwagha, Uchenna Ifeanyi, Okeke, Tochukwu Christopher, Nwagha, Theresa Ukamaka, Ejezie, Fidelis Ebele, Ogbodo, Sylvester Ogbonna, Dim, Cyril Chukwudi, Anyaehie, Bond Ugochukwu
Format: Journal Article
Language:English
Published: India 01-03-2011
Subjects:
Adult
Asymptomatic Infections
Blood - parasitology
Blood Chemical Analysis
Cross-Sectional Studies
Female
Humans
Malaria - complications
Malaria - diagnosis
Malaria - parasitology
Nigeria
Oxidative Stress
Parasitemia - complications
Parasitemia - diagnosis
Parasitemia - parasitology
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - parasitology
Nigeria
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Summary:To determine the relationship between asymptomatic malaria parasitemia and some oxidative stress parameters in pregnant Nigerian women. This is a cross-sectional study involving 130 normal pregnant women at various trimesters, who were attending antenatal clinic at the University of Nigeria Teaching Hospital (UNTH) and Kenechukwu Specialist Hospital in Enugu. A comparable group (control), made of 30 non pregnant women was also recruited. After a 24 hour dietary recall, serum levels of vitamin A, C and malondialdehyde (MDA) were determined by colorimetric method, while vitamin E was determined by absorptiometric method. There were no statistically significant differences in age, parity, estimated calorie, vitamins A, C and E intake between the pregnant and non pregnant groups (P> 0.05). The serum level of the vitamins (umol/L) and MDA (umol/L) in control, 1st, 2nd and 3rd trimesters respectively were: (1)Vitamin A: 1.6±0.36 vs 0.6±0.26 vs 0.62± 0.33 vs 0.46± 0.21 (P < 0.0001); (2) Vitamin C: 75.65±14.15 vs 62.97±24.4 vs 37.85±15.19 vs 28.94±8.52 (P<0.0001); (3) Vitamin E: 3.01± 1.32 vs 3.45±2.01 vs 9.36±2.75 vs 9.82±2.97 (P<0.0001); (4) MDA: 1.42± 0.02 vs 1.61±0.02 vs 1.79±0.02 vs 2.03±0.05 (P<0.0001). However, there were no significant changes in the serum level of the vitamins and MDA between the positive and the negative parasitemia subjects (P>0.05). Asymptomatic malaria parasitemia does not induce additional oxidative stress on pregnant women in Nigeria. The enormity of acute and complicated attack should be further investigated.
ISSN:2352-4146
DOI:10.1016/S1995-7645(11)60076-X