Search Results - "Ogawa, Shin"

Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment by Ogawa, Shin-ichiro, Shimizu, Makiko, Yamazaki, Hiroshi

“…Pharmacokinetic profiles of pemafibrate with virtual drug and/or disease interactions were assessed by creating a detailed physiologically based…”
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Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations by Ogawa, Shin-ichiro, Shimizu, Makiko, Yamazaki, Hiroshi

“…Oral antidyslipidaemic drug pemafibrate is cleared from human plasma via hepatic uptake by organic anion transporting polypeptide (OATP) 1B1 and oxidation by…”
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Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator‐activated receptor‐alpha modulator, in rats and monkeys by Ogawa, Shin‐ichiro, Tsunenari, Yoshihiko, Kawai, Hiroyuki, Yamazaki, Hiroshi

“…The metabolic profiles and pharmacokinetics of pemafibrate, a novel selective peroxisome proliferator activated receptor‐alpha modulator currently launched as…”
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Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver by Ogawa, Shin-ichiro, Uehara, Shotaro, Tsunenari, Yoshihiko, Kawai, Hiroyuki, Suemizu, Hiroshi, Yamazaki, Hiroshi

“…Pharmacokinetics and metabolism of recently launched antidyslipidemic drug pemafibrate…”
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Quantitative Determination of H2 in Human Blood by 22Ne-aided Gas Chromatography–Mass Spectrometry Using a Single Quadrupole Instrument by TSUJITA, Akira, NAGASAKA, Asami, OKAZAKI, Hidehiko, OGAWA, Shin, GOHDA, Akinaga, MATSUI, Toshiro

“…Here, we present a quantitative method for H2 detection by gas chromatography–selected ion monitoring–mass spectrometry (GC-SIM-MS) using a single quadrupole…”
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Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1 by Ogawa, Shin-ichiro, Shimizu, Makiko, Kamiya, Yusuke, Uehara, Shotaro, Suemizu, Hiroshi, Yamazaki, Hiroshi

“…In vitro permeability and in vivo pharmacokinetics of pemafibrate were investigated in human intestinal and animal models untreated or pretreated with…”
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Reducing bacterial counts around the abutment following professional mechanical plaque removal at the implant bridge: A randomized crossover comparison of removing or not removing the superstructure by Arai, Yoshiaki, Inanobe-Takatsuka, Mutsumi, Takashima, Makiko, Ogawa, Shin, Kawamura, Atsushi, Nohno, Kaname, Uoshima, Katsumi

“…The purpose of this study was to determine whether removing the superstructure of the implant bridge in cases of full-arch implant restorations for edentulous…”
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Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase by Fujino, Hideki, Saito, Tsuyoshi, Ogawa, Shin-ichiro, Kojima, Junji

“…The purpose of this study was to gain a better understanding of the transport mechanism of pitavastatin, a novel synthetic HMG‐CoA reductase inhibitor…”
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Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells by Ogawa, Shin-ichiro, Tokumoto, Yasuhito, Miyake, Jun, Nagamune, Teruyuki

“…Induced pluripotent stem cells (iPSCs) prepared from somatic cells might become a novel therapeutic tool in regenerative medicine, especially for the central…”
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The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus by Liu, Yuan, Ye, Josephine, Shin Ogawa, Luisa, Inoue, Takayo, Huang, Qin, Chu, John, Bates, Richard C, Ying, Weiwen, Sonderfan, Andrew J, Rao, Patricia E, Zhou, Dan

“…Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease with a diverse range of immunological and clinical manifestations. The…”
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Brain Targeting of Acyl-CoA:Cholesterol O‑Acyltransferase‑1 Inhibitor K‑604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution by Shibuya, Kimiyuki, Morikawa, Shigeru, Miyamoto, Masayoshi, Ogawa, Shin-ichiro, Tsunenari, Yoshihiko, Urano, Yasuomi, Noguchi, Noriko

“…An acyl-CoA:cholesterol O-acyltransferase-1 (ACAT-1/SOAT-1) inhibitor, K-604 is a promising drug candidate for the treatment of Alzheimer’s disease and…”
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Immunopanning selection of A2B5-positive cells increased the differentiation efficiency of induced pluripotent stem cells into oligodendrocytes by Ogawa, Shin-ichiro, Tokumoto, Yasuhito, Miyake, Jun, Nagamune, Teruyuki

“…▶In vitro oligodendrocyte differentiation from mouse iPS cells was carried out. ▶ Mouse monoclonal antibody A2B5 was used for immunopanning selection. ▶ The…”
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The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells by Nagai, Masazumi, Vo, Nha H., Shin Ogawa, Luisa, Chimmanamada, Dinesh, Inoue, Takayo, Chu, John, Beaudette-Zlatanova, Britte C., Lu, Rongzhen, Blackman, Ronald K., Barsoum, James, Koya, Keizo, Wada, Yumiko

“…Elesclomol is an investigational drug that exerts potent anticancer activity through the elevation of reactive oxygen species (ROS) levels and is currently…”
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High-Resolution Three-Dimensional Computed Tomography Analysis of the Clinical Efficacy of Cultured Autogenous Periosteal Cells in Sinus Lift Bone Grafting by Ogawa, Shin, Hoshina, Hideyuki, Nakata, Koh, Yamada, Kazuho, Uematsu, Kohya, Kawase, Tomoyuki, Takagi, Ritsuo, Nagata, Masaki

“…Background and Purpose Sinus lift (SL) using cultured autogenous periosteal cells (CAPCs) combined with autogenous bone and platelet‐rich plasma (PRP) was…”
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Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy by Ying, Weiwen, Du, Zhenjian, Sun, Lijun, Foley, Kevin P, Proia, David A, Blackman, Ronald K, Zhou, Dan, Inoue, Takayo, Tatsuta, Noriaki, Sang, Jim, Ye, Shuxia, Acquaviva, Jamie, Ogawa, Luisa Shin, Wada, Yumiko, Barsoum, James, Koya, Keizo

“…Targeted inhibition of the molecular chaperone Hsp90 results in the simultaneous blockade of multiple oncogenic signaling pathways and has, thus, emerged as an…”
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Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice by Watase, Kei, Hashimoto, Kouichi, Kano, Masanobu, Yamada, Keiko, Watanabe, Masahiko, Inoue, Yoshiro, Okuyama, Shigeru, Sakagawa, Takashi, Ogawa, Shin-ichi, Kawashima, Naoya, Hori, Seiji, Takimoto, Misato, Wada, Keiji, Tanaka, Kohichi

“…To study the function of GLAST, a glutamate transporter highly expressed in the cerebellar Bergmann astrocytes, the mouse GLAST gene was inactivated…”
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Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme by Miwa, Kazuhiro, Matsuo, Masayuki, Ogawa, Shin-ichi, Shinoda, Jun, Asano, Yoshitaka, Ito, Takeshi, Yokoyama, Kazutoshi, Yamada, Jitsuhiro, Yano, Hirohito, Iwama, Toru

“…This research paper presents clinical outcomes of hypofractionated high-dose irradiation by intensity-modulated radiation therapy (Hypo-IMRT) with…”
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Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population by Kairupan, Tara Sefanya, Ibusuki, Rie, Kheradmand, Motahare, Sagara, Yasuko, Mantjoro, Eva Mariane, Nindita, Yora, Niimura, Hideshi, Kuwabara, Kazuyo, Ogawa, Shin, Tsumematsu-Nakahata, Noriko, Nerome, Yasuhito, Owaki, Tetsuhiro, Matsushita, Toshifumi, Maenohara, Shigeho, Yamaguchi, Kazunari, Takezaki, Toshiro

“…An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors…”
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Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study by Sugimoto, Yuka, Wakai, Kenji, Nakagawa, Hiroko, Suma, Shino, Sasakabe, Tae, Sakamoto, Tatsuhiko, Takashima, Naoyuki, Suzuki, Sadao, Ogawa, Shin, Ohnaka, Keizo, Kuriyama, Nagato, Arisawa, Kokichi, Mikami, Haruo, Kubo, Michiaki, Hosono, Satoyo, Hamajima, Nobuyuki, Tanaka, Hideo

“…Cytokines, including interleukin-6 (IL-6), play an important role in the liver. The aim of this study was to investigate associations between common…”
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Positive Association of Plasma Homocysteine Levels with Cardio-Ankle Vascular Index in a Prospective Study of Japanese Men from the General Population by Mantjoro, Eva Mariane, Toyota, Kousuke, Kanouchi, Hiroaki, Kheradmand, Motahare, Niimura, Hideshi, Kuwabara, Kazuyo, Nakahata, Noriko, Ogawa, Shin, Shimatani, Keiichi, Kairupan, Tara Sefanya, Nindita, Yora, Ibusuki, Rie, Nerome, Yasuhito, Owaki, Tetsuhiro, Maenohara, Shigeho, Takezaki, Toshiro

“…Aim: Observational studies have reported that elevated homocysteine (Hcy) levels are associated with the risk of cardiovascular disease (CVD). However,…”
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