Search Results - "Ogata, Fernando T."

Glutaredoxin: Discovery, redox defense and much more by Ogata, Fernando T., Branco, Vasco, Vale, Filipa F., Coppo, Lucia

“…Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx,…”
Get full text

The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress by Ren, Xiaoyuan, Santhosh, Sebastin M., Coppo, Lucia, Ogata, Fernando T., Lu, Jun, Holmgren, Arne

“…The combination of ascorbate and menadione (VC:VK3 = 100:1) is an investigational treatment for cancer under clinical trials. Dehydroascorbic acid (DHA), the…”
Get full text

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance by Palma, Flavio R., Coelho, Diego R., Pulakanti, Kirthi, Sakiyama, Marcelo J., Huang, Yunping, Ogata, Fernando T., Danes, Jeanne M., Meyer, Alison, Furdui, Cristina M., Spitz, Douglas R., Gomes, Ana P., Gantner, Benjamin N., Rao, Sridhar, Backman, Vadim, Bonini, Marcelo G.

“…Chromatin structure is regulated through posttranslational modifications of histone variants that modulate transcription. Although highly homologous, histone…”
Get full text

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance by Palma, Flavio R., Coelho, Diego R., Pulakanti, Kirthi, Sakiyama, Marcelo J., Huang, Yunping, Ogata, Fernando T., Danes, Jeanne M., Meyer, Alison, Furdui, Cristina M., Spitz, Douglas R., Gomes, Ana P., Gantner, Benjamin N., Rao, Sridhar, Backman, Vadim, Bonini, Marcelo G.

Get full text

TGF-β-Based Therapies for Treating Ocular Surface Disorders by Ogata, Fernando T, Verma, Sudhir, Coulson-Thomas, Vivien J, Gesteira, Tarsis F

“…The cornea is continuously exposed to injuries, ranging from minor scratches to deep traumas. An effective healing mechanism is crucial for the cornea to…”
Get full text

Thioredoxin promotes survival signaling events under nitrosative/oxidative stress associated with cancer development by Monteiro, Hugo P, Ogata, Fernando T, Stern, Arnold

“…Accumulating mutations may drive cells into the acquisition of abnormal phenotypes that are characteristic of cancer cells. Cancer cells feature profound…”
Get full text

Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective by Monteiro, Hugo P., Rodrigues, Elaine G., Amorim Reis, Adriana K.C., Longo, Luiz S., Ogata, Fernando T., Moretti, Ana I.S., da Costa, Paulo E., Teodoro, Ana C.S., Toledo, Maytê S., Stern, Arnold

“…Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell…”
Get full text

Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing by Verma, Sudhir, Ogata, Fernando T., Moreno, Isabel Y., Prinholato da Silva, Cassio, Marforio, Tainah Dorina, Calvaresi, Matteo, Sen, Mehmet, Coulson-Thomas, Vivien J., Gesteira, Tarsis Ferreira

“…Lumican is a major extracellular matrix (ECM) component in the cornea that is upregulated after injury and promotes corneal wound healing. We have recently…”
Get full text

Enzymatic glutaredoxin-dependent method to determine glutathione and protein S-glutathionylation using fluorescent eosin-glutathione by Coppo, Lucia, Ogata, Fernando T., Santhosh, Sebastin M., Sventelius, Teodor, Holmgren, Arne

“…Glutathione is an abundant low-molecular-weight thiol, up to 10 mM in mammalian cells, and exists in three major forms: reduced sulphydryl (GSH), glutathione…”
Get full text

Nitric oxide stimulates a PKC-Src-Akt signaling axis which increases human immunodeficiency virus type 1 replication in human T lymphocytes by Curcio, Marli F., Batista, Wagner L., Castro, Eloísa D., Strumillo, Scheilla T., Ogata, Fernando T., Alkmim, Wagner, Brunialti, Milena K.C., Salomão, Reinaldo, Turcato, Gilberto, Diaz, Ricardo S., Monteiro, Hugo P., Janini, Luiz Mário R.

“…Human immunodeficiency virus (HIV) infections are typically accompanied by high levels of secreted inflammatory cytokines and generation of high levels of…”
Get full text

Heparan sulfate proteoglycan deficiency up‐regulates the intracellular production of nitric oxide in Chinese hamster ovary cell lines by Lucena, Sheyla V., Moura, Gioconda E. D. D., Rodrigues, Tiago, Watashi, Carolina M., Melo, Fabiana H., Icimoto, Marcelo Y., Viana, Gustavo M., Nader, Helena B., Monteiro, Hugo P., Tersariol, Ivarne L. S., Ogata, Fernando T.

“…We investigated the role of glycosaminoglycans (GAGs) in the regulation of endothelial nitric oxide synthase (eNOS) activity in wild‐type CHO‐K1 cells and in…”
Get full text

S-nitrosoglutathione and endothelial nitric oxide synthase-derived nitric oxide regulate compartmentalized ras S-nitrosylation and stimulate cell proliferation by Batista, Wagner L, Ogata, Fernando T, Curcio, Marli F, Miguel, Rodrigo B, Arai, Roberto J, Matsuo, Alisson L, Moraes, Miriam S, Stern, Arnold, Monteiro, Hugo P

“…S-nitrosylation of Cys118 is a redox-based mechanism for Ras activation mediated by nitric oxide (NO) at the plasma membrane. Ras signaling pathway stimulation…”
Get more information

A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model by Gesteira, Tarsis F., Coulson-Thomas, Vivien Jane, Ogata, Fernando T., Farias, Eduardo H.C., Cavalheiro, Renan P., de Lima, Marcelo A., Cunha, Gabriel L.A., Nakayasu, Ernesto S., Almeida, Igor C., Toma, Leny, Nader, Helena B.

“…Proteoglycans encompass a heterogeneous group of glycoconjugates where proteins are substituted with linear, highly negatively charged glycosaminoglycan…”
Get full text

Thioredoxin-1 promotes survival in cells exposed to S-nitrosoglutathione: Correlation with reduction of intracellular levels of nitrosothiols and up-regulation of the ERK1/2 MAP Kinases by Arai, Roberto J., Ogata, Fernando T., Batista, Wagner L., Masutani, Hiroshi, Yodoi, Junji, Debbas, Victor, Augusto, Ohara, Stern, Arnold, Monteiro, Hugo P.

“…Accumulating evidence indicates that post-translational protein modifications by nitric oxide and its derived species are critical effectors of redox signaling…”
Get full text

The nitric oxide-sensitive p21Ras–ERK pathway mediates S-nitrosoglutathione-induced apoptosis by Tsujita, Maristela, Batista, Wagner L., Ogata, Fernando T., Stern, Arnold, Monteiro, Hugo P., Arai, Roberto J.

“…p21Ras protein plays a critical role in cellular signaling that induces either cell cycle progression or apoptosis. Nitric oxide (NO) has been consistently…”
Get full text