Search Results - "Ofori, Ebenezer Addo"
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Towards large-scale identification of HLA-restricted T cell epitopes from four vaccine candidate antigens in a malaria endemic community in Ghana
Published in Vaccine (31-01-2022)“…•Plasmodium CSP and AMA1 exhibited more T cell epitopes compared to TRAP and CelTOS.•The most frequent T cell responses to the four antigens were to the CSP…”
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Prevalence of sickle cell disorders and malaria infection in children aged 1-12 years in the Volta Region, Ghana: a community-based study
Published in Malaria journal (23-11-2020)“…Alterations in the structure of haemoglobin (Hb) are usually brought about by point mutations affecting one or, in some cases, two codons encoding amino acids…”
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Immunodominant T cell peptides from four candidate malarial antigens as biomarkers of protective immunity against malaria
Published in Vaccine (03-02-2023)“…•135 T cell epitopes identified in four P. falciparum antigen, with 75 % being novel.•Thirty-two percent (32%) of the 135 epitopes show promiscuity in HLA…”
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Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response
Published in Frontiers in microbiology (17-11-2020)“…Pro- and anti-inflammatory cytokines are important mediators of immunity and are associated with malaria disease outcomes. However, their role in the…”
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ProC6C, a novel multi-stage malaria vaccine, elicits functional antibodies against the minor and central repeats of the Circumsporozoite Protein in human adults
Published in Frontiers in immunology (01-11-2024)“…ProC6C is a multi-stage malaria vaccine which includes Plasmodium falciparum Circumsporozoite Protein (PfCSP), Pfs48/45 and Pfs230 sequences, designed to…”
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Human blood neutrophils generate ROS through FcγR-signaling to mediate protection against febrile P. falciparum malaria
Published in Communications biology (18-07-2023)“…Blood phagocytes, such as neutrophils and monocytes, generate reactive oxygen species (ROS) as a part of host defense response against infections. We…”
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Corrigendum: Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response
Published in Frontiers in microbiology (19-05-2021)“…[This corrects the article DOI: 10.3389/fmicb.2020.559255.]…”
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Macrophage susceptibility to infection by Ghanaian Mycobacterium tuberculosis complex lineages 4 and 5 varies with self-reported ethnicity
Published in Frontiers in cellular and infection microbiology (14-08-2023)“…The epidemiology of complex (MTBC) lineage 5 (L5) infections in Ghana revealed a significantly increased prevalence in Ewes compared to other self-reported…”
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Production and Purification of Plasmodium Circumsporozoite Protein in Lactococcus lactis
Published in Methods in molecular biology (Clifton, N.J.) (2024)“…Malaria is a vector-borne disease caused by Plasmodium parasites of which Plasmodium falciparum contributed to an estimated 247 million cases worldwide in 2021…”
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A randomized first-in-human phase I trial of differentially adjuvanted Pfs48/45 malaria vaccines in Burkinabé adults
Published in The Journal of clinical investigation (01-04-2024)“…BACKGROUND. Malaria transmission-blocking vaccines aim to interrupt the transmission of malaria from one person to another. METHODS. The candidates R0.6C and…”
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