Search Results - "Ofner, M"

Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells by Nicoletto, Rachel E., Ofner, Clyde M.

“…Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety of tumor types, such as breast cancer. Despite the long history of…”
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Carbodiimide Induced Cross-Linking, Ligand Addition, and Degradation in Gelatin by Cammarata, Christopher R, Hughes, Mitchell E, Ofner, Clyde M

“…The water-soluble carbodiimide, 1-ethyl-3-(3-(dimethylaminopropyl)-carbodiimide (EDC) is widely used in protein chemistry. We used EDC-induced gelatin…”
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Aldosterone and parathyroid hormone: a precarious couple for cardiovascular disease by TOMASCHITZ, Andreas, RITZ, Eberhard, PILZ, Stefan, PIESKE, Burkert, FAHRLEITNER-PAMMER, Astrid, KIENREICH, Katharina, HORINA, Jörg H, DRECHSLER, Christiane, MÄRZ, Winfried, OFNER, Michael, PIEBER, Thomas R

“…Animal and human studies support a clinically relevant interaction between aldosterone and parathyroid hormone (PTH) levels and suggest an impact of the…”
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Intracellular trafficking and cytotoxicity of a gelatine-doxorubicin conjugate in two breast cancer cell lines by Alvi, Mohammed M., Nicoletto, Rachel E., Eshmawi, Bayan A., Kim, Hyun (Kate), Cammarata, Christopher R., Ofner, Clyde M.

“…Details of intracellular pathways of cytotoxicity remain unclear for doxorubicin conjugates being studied to treat breast cancer tumours. A high molecular…”
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Adsorption and Degradation of Doxorubicin from Aqueous Solution in Polypropylene Containers by Wu, Darren C., Ofner, Clyde M.

“…The purpose of this study was to examine doxorubicin adsorption in polypropylene containers as a function of pH and drug concentration based on anecdotal…”
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Point prevalence survey for healthcare-associated infections within Canadian adult acute-care hospitals by Gravel, D, Taylor, G, Ofner, M, Johnston, L, Loeb, M, Roth, V.R, Stegenga, J, Bryce, E, the Canadian Nosocomial Infection Surveillance Program, Matlow, Anne

“…Summary A survey of adult patients 19 years of age and older was conducted in February 2002 in hospitals across Canada to estimate the prevalence of…”
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Effect of Molecular Weight, Drug Load, and Charge of Gelatin-MTX Conjugates on Growth Inhibition of HL-60 Leukemia Cells by Chen, Chao-Sheng, Ofner, Clyde M. III

“…Purpose Gelatin-methotrexate conjugates (G-MTX) with known molecular weight (MW), drug load, and charge were prepared and evaluated for growth inhibition on…”
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Preparation, Drug Release, and Cell Growth Inhibition of a Gelatin: Doxorubicin Conjugate by Wu, Darren C., Cammarata, Christopher R., Park, Hyun Joo, Rhodes, Brian T., Ofner, Clyde M.

“…Purpose To demonstrate the feasibility of a novel macromolecular delivery system for doxorubicin (DOX) which combines pH dependent DOX release with a high…”
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Crosslinked gelatin matrices: release of a random coil macromolecular solute by Mwangi, Jane W., Ofner, Clyde M.

“…The purpose of this investigation was to evaluate the effect of matrix crosslinking and solute size on release of a random coil macromolecular solute from…”
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Gelatin-methotrexate conjugate microspheres as a potential drug delivery system by Pica, Karen, Tchao, Ruy, Ofner, 3rd, Clyde M

“…Gelatin-methotrexate microspheres for intra-tumor administration have possibilities for minimizing systemic toxicities of methotrexate (MTX) and overcoming its…”
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Growth inhibition, drug load, and degradation studies of gelatin/methotrexate conjugates by Ofner, Clyde M., Pica, Karen, Bowman, Bill J., Chen, Chao-Sheng

“…Macromolecular gelatin-methotrexate conjugates have potential therapeutic advantages over the free drug. Conjugates with MTX:gelatin molar ratios (MR) ranging…”
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Chemical and swelling evaluations of amino group crosslinking in gelatin and modified gelatin matrices by OFNER, C. M, BUBNIS, W. A

“…To determine the extent of amino group crosslinking in gelatin matrices by chemical assay, and to compare these results to crosslinking evaluations from…”
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Crosslinking studies in gelatin capsules treated with formaldehyde and in capsules exposed to elevated temperature and humidity by Ofner, 3rd, C M, Zhang, Y E, Jobeck, V C, Bowman, B J

“…Incomplete in vitro capsule shell dissolution and subsequent drug release problems have recently received attention. A modified USP dissolution method was used…”
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Characterization and in vitro release of methotrexate from gelatin/methotrexate conjugates formed using different preparation variables by Kosasih, A, Bowman, Bill J, Wigent, Rodney J, Ofner, Clyde M

“…The purpose of this study was to evaluate effects of preparation variables on the composition of gelatin-methotrexate conjugates, and to evaluate their in…”
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Multitemperature Stability and Degradation Characteristics of Pergolide Mesylate Oral Liquid by Shank, Brandon R., Ofner, Clyde M.

“…The stability of pergolide mesylate in an oral aqueous liquid was studied. Stability and solubility data were used to determine the degradation characteristics…”
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Characterization and in vitro methotrexate release from methotrexate/gelatin conjugates of opposite conjugate bond polarity by BOWMAN, Bill J, OFNER, Clyde M

“…Our laboratory has previously prepared gelatin/ methotrexate (MTX) conjugates containing mixed conjugation sites and by-product crosslinking, both of which may…”
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Examination of self-crosslinked gelatin as a hydrogel for controlled release by Welz, M M, Ofner, 3rd, C M

“…A gelatin matrix crosslinked by extensive dehydration was examined for use in controlled drug delivery in this preliminary investigation. Crosslinking is…”
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Single tree detection in very high resolution remote sensing data by Hirschmugl, Manuela, Ofner, Martin, Raggam, Johann, Schardt, Mathias

“…Tree detection is a major focus in the field of (semi-) automatic extraction of forest information from very high resolution remote sensing data. Many existing…”
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A comparison of risk factors associated with community-associated methicillin-resistant and -susceptible Staphylococcus aureus infections in remote communities by GOLDING, G. R., LEVETT, P. N., McDONALD, R. R., IRVINE, J., NSUNGU, M., WOODS, S., HORBAL, A., SIEMENS, C. G., KHAN, M., OFNER-AGOSTINI, M., MULVEY, M. R.

“…In this case-control study, cases [community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), n=79] and controls [community-associated…”
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A qualitative investigation into an HIV outbreak among injection drug users in Vancouver, British Columbia by HARVEY, E., STRATHDEE, S. A., PATRICK, D. M., OFNER, M., ARCHIBALD, C. P., EADES, G., O'SHAUGHNESSY, M. V.

“…The proportion of injection drug users (IDUs) testing positive for Human Immunodeficiency Virus (HIV) in British Columbia has increased from 3 to 7% since…”
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