Search Results - "Offord, Steve J"

The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review by Maletic, Vladimir, Eramo, Anna, Gwin, Keva, Offord, Steve J, Duffy, Ruth A

“…Norepinephrine (NE) is recognized as having a key role in the pathophysiology of major depressive disorder (MDD) and schizophrenia, although its distinct…”
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Efficacy and Effectiveness of Depot Versus Oral Antipsychotics in Schizophrenia: Synthesizing Results Across Different Research Designs by KIRSON, Noam Y, WEIDEN, Peter J, YERMAKOV, Sander, HUANG, Wayne, SAMUELSON, Thomas, OFFORD, Steve J, GREENBERG, Paul E, WONG, Bruce J. O

“…Nonadherence is a major challenge in schizophrenia treatment. While long-acting (depot) antipsychotic medications are often recommended to address adherence…”
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Inpatient resource use and costs associated with switching from oral antipsychotics to aripiprazole once-monthly for the treatment of schizophrenia by Wilson, Michele, Gutierrez, Benjamin, Offord, Steve J, Blanchette, Christopher M, Eramo, Anna, Earnshaw, Stephanie, Kamat, Siddhesh A

“…Schizophrenia is associated with high direct healthcare costs due to progression of disease and frequent occurrence of relapses. Aripiprazole once-monthly…”
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Long-term outcomes of antipsychotic treatment in patients with first-episode schizophrenia: a systematic review by Karson, Craig, Duffy, Ruth A, Eramo, Anna, Nylander, Anna-Greta, Offord, Steve J

“…Treatment during first-episode psychosis (FEP) or early schizophrenia may affect the rates of relapse and remission, as well as cognitive functioning, over…”
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Lack of tolerable treatment options for patients with schizophrenia by Citrome, Leslie, Eramo, Anna, Francois, Clement, Duffy, Ruth, Legacy, Susan N, Offord, Steve J, Krasa, Holly B, Johnston, Stephen S, Guiraud-Diawara, Alice, Kamat, Siddhesh A, Rohman, Patricia

“…Atypical antipsychotics (AAs), an effective treatment for schizophrenia, have a range of pharmacologic properties leading to differences in tolerability as…”
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The Role of Positron Emission Tomography in the Drug Development of M100907, a Putative Antipsychotic with a Novel Mechanism of Action by Offord, Steve J., Wong, Dean F., Nyberg, Svante

“…Antipsychotic drug development has been a slow process since the discovery of chlorpromazine more than 45 years ago. Researchers identify a large number of…”
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Long-term outcomes of antipsychotic treatment in patients with first-episode schizophrenia: a systematic review by Karson, Craig, Duffy, Ruth A, Eramo, Anna, Nylander, Anna-Greta, Offord, Steve J

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Continuous Intravenous Infusion of Iodine-123-IBZM for SPECT Determination of Human Brain Dopamine Receptor Occupancy by Antipsychotic Agent RWJ-37796 by Seibyl, John P, Zea-Ponce, Yolanda, Brenner, Louise, Baldwin, Ronald M, Krystal, John H, Offord, Steve J, Mochoviak, Sandra, Charney, Dennis S, Hoffer, Paul B, Innis, Robert B

“…PET has shown that dose-dependent in vivo occupancy of dopamine receptors by antipsychotic drugs is associated with clinical response to antipsychotic agents…”
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The importance of a wide therapeutic window: Fexofenadine is safe and effective over a broad range of plasma concentrations by Offord, Steve J

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Time Course of 5-HT Receptor Occupancy in the Human Brain after a Single Oral Dose of the Putative Antipsychotic Drug MDL 100,907 Measured by Positron Emission Tomography

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The effect of chronic treatment with a novel aryl-piperazine antipsychotic on monoamine receptors in rat brain by Shapiro, Laura A., Offord, Steve J., Ordway, Gregory A.

“…The effects of chronic treatment of rats with RWJ 3776, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats…”
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Time Course of 5-HT2A Receptor Occupancy in the Human Brain after a Single Oral Dose of the Putative Antipsychotic Drug MDL 100,907 Measured by Positron Emission Tomography by Gründer, M.D, Gerhard, Yokoi, M.D, Fuji, Offord, Ph.D, Steve J., Ravert, Ph.D, Hayden T., Dannals, Ph.D, Robert F., Salzmann, M.S, Joanne K., Szymanski, D.O, Sally, Wilson, Ph.D, P.David, Howard, Ph.D, Daniel R., Wong, M.D., Ph.D, Dean F.

“…MDL 100,907 is a potent and selective antagonist of 5-HT2A serotonin receptors. Animal studies suggest that MDL 100,907 may behave as an atypical antipsychotic…”
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Ketanserin alters [3H]serotonin uptake and release in rat hypothalamus by Offord, S J, Warwick, Jr, R O

“…Ketanserin, a serotonin2 receptor antagonist, evoked a dose-related non-calcium dependent release of tritium from slices of rat hypothalamus preloaded with…”
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Differential effects of nialamide and clomipramine on serotonin efflux and autoreceptors by Offord, S J, Warwick, Jr, R O

“…Serotonin (5-HT) activity in vivo and in vitro was evaluated in rats following acute and chronic administration of the antidepressants nialamide (NMD) and…”
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