Search Results - "Offit, Ken"

Germline Lysine-Specific Demethylase 1 ( LSD1/KDM1A ) Mutations Confer Susceptibility to Multiple Myeloma by Wei, Xiaomu, Calvo-Vidal, M Nieves, Chen, Siwei, Wu, Gang, Revuelta, Maria V, Sun, Jian, Zhang, Jinghui, Walsh, Michael F, Nichols, Kim E, Joseph, Vijai, Snyder, Carrie, Vachon, Celine M, McKay, James D, Wang, Shu-Ping, Jayabalan, David S, Jacobs, Lauren M, Becirovic, Dina, Waller, Rosalie G, Artomov, Mykyta, Viale, Agnes, Patel, Jayeshkumar, Phillip, Jude, Chen-Kiang, Selina, Curtin, Karen, Salama, Mohamed, Atanackovic, Djordje, Niesvizky, Ruben, Landgren, Ola, Slager, Susan L, Godley, Lucy A, Churpek, Jane, Garber, Judy E, Anderson, Kenneth C, Daly, Mark J, Roeder, Robert G, Dumontet, Charles, Lynch, Henry T, Mullighan, Charles G, Camp, Nicola J, Offit, Kenneth, Klein, Robert J, Yu, Haiyuan, Cerchietti, Leandro, Lipkin, Steven M

“…Given the frequent and largely incurable occurrence of multiple myeloma, identification of germline genetic mutations that predispose cells to multiple myeloma…”
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Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis by Bolton, Kelly L., Ptashkin, Ryan N., Gao, Teng, Braunstein, Lior, Devlin, Sean M., Patel, Minal, Berthon, Antonin, Syed, Aijazuddin, Yabe, Mariko, Coombs, Catherine, Caltabellotta, Nicole M., Walsh, Mike, Offit, Ken, Stadler, Zsofia, Lee, Choonsik, Pharoah, Paul, Stopsack, Konrad H., Spitzer, Barbara, Mantha, Simon, Fagin, James, Boucai, Laura, Gibson, Christopher J., Ebert, Benjamin, Young, Andrew L., Druley, Todd, Takahashi, Koichi, Gillis, Nancy, Ball, Markus, Padron, Eric, Hyman, David, Baselga, Jose, Norton, Larry, Gardos, Stuart, Klimek, Virginia, Scher, Howard, Bajorin, Dean, Paraiso, Eder, Benayed, Ryma, Arcilla, Maria, Ladanyi, Marc, Solit, David, Berger, Michael, Tallman, Martin, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Diaz, Luis, Levine, Ross, Morton, Lindsay, Zehir, Ahmet, Papaemmanuil, Elli

“…Abstract Recent studies among healthy individuals show evidence of somatic mutations in leukemia-associated genes, referred to as clonal hematopoiesis (CH). To…”
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Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer by Zuber, Verena, Bettella, Francesco, Witoelar, Aree, Andreassen, Ole A, Mills, Ian G, Urbanucci, Alfonso

“…Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer…”
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What Women with Breast Cancer Discuss with Clinicians About Risk for Their Adolescent Daughters by Maloney, Erin, Edgerson, Shawna, Robson, Mark, Offit, Ken, Brown, Richard, Bylund, Carma, Kissane, David W.

“…Recorded conversations between women undergoing BRCA genetic counseling with clinicians (N = 16) and follow-up consultation letters (N = 16) were analyzed to…”
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Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study by Brooks, Jennifer D., Teraoka, Sharon N., Reiner, Anne S., Satagopan, Jaya M., Bernstein, Leslie, Thomas, Duncan C., Capanu, Marinela, Stovall, Marilyn, Smith, Susan A., Wei, Shan, Shore, Roy E., Boice Jr, John D., Lynch, Charles F., Mellemkjær, Lene, Malone, Kathleen E., Liang, Xiaolin, the WECARE Study Collaborative Group, Haile, Robert W., Concannon, Patrick, Bernstein, Jonine L.

“…Ionizing radiation (IR) is a breast carcinogen that induces DNA double‐strand breaks (DSBs), and variation in genes involved in the DNA DSB response has been…”
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Evaluation of Linkage of Breast Cancer to the Putative BRCA3 Locus on Chromosome 13q21 in 128 Multiple Case Families from the Breast Cancer Linkage Consortium by Thompson, Deborah, Szabo, Csilla I., Mangion, Jon, Oldenburg, Rogier A., Odefrey, Fabrice, Seal, Sheila, Barfoot, Rita, Kroeze-Jansema, Karin, Teare, Dawn, Rahman, Nazneen, Renard, Hélène, KCon Fab Consortium, Mann, Graham, Hopper, John L., Buys, Saundra S., Andrulis, Irene L., Senie, Ruby, Daly, Mary B., West, Dee, Ostrander, Elaine A., Offit, Ken, Peretz, Tamar, Osorio, Ana, Benitez, J., Nathanson, Katherine L., Sinilnikova, Olga M., Oláh, Edith, Bignon, Yves-Jean, Ruiz, Pablo, Badzioch, Michael D., Hans F. A. Vasen, Futreal, Andrew P., Phelan, Catherine M., Narod, Steven A., Lynch, Henry T., Bruce A. J. Ponder, Eeles, Ros A., Meijers-Heijboer, Hanne, Stoppa-Lyonnet, Dominique, Couch, Fergus J., Eccles, Diana M., Evans, D. Gareth, Chang-Claude, Jenny, Lenoir, Gilbert, Weber, Barbara L., Devilee, Peter, Easton, Douglas F., Goldgar, David E., Stratton, Michael R.

“…The known susceptibility genes for breast cancer, including BRCA1 and BRCA2, only account for a minority of the familial aggregation of the disease. A recent…”
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Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families : Results of an international study by NEUHAUSEN, S. L, MAZOYER, S, SOLOMON, E, WEBER, B, COUCH, F, STRUEWING, J, TONIN, P, DUROCHER, F, NAROD, S, SKOLNICK, M. H, LENOIR, G, SEROVA, O, FRIEDMAN, L, PONDER, B, STOPPA-LYONNET, D, EASTON, D, KING, M.-C, GOLDGAR, D. E, STRATTON, M, OFFIT, K, CALIGO, A, TOMLINSON, G, CANNON-ALBRIGHT, L, BISHOP, T, KELSELL, D

“…Several BRCA1 mutations have now been found to occur in geographically diverse breast and ovarian cancer families. To investigate mutation origin and…”
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