Search Results - "Offerman, E. H."

APOE3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome by van den Hoek, A. M., van der Hoorn, J. W. A., Maas, A. C., van den Hoogen, R. M., van Nieuwkoop, A., Droog, S., Offerman, E. H., Pieterman, E. J., Havekes, L. M., Princen, H. M. G.

“…Aims This study aimed to investigate systematically (i) the appropriate dietary conditions to induce the features of the MetS in APOE*3Leiden.humanCholesteryl…”
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No Effect of C-Reactive Protein on Early Atherosclerosis Development in Apolipoprotein E3-Leiden/Human C-Reactive Protein Transgenic Mice by Trion, A, de Maat, M P.M, Jukema, J W, van der Laarse, A, Maas, M C, Offerman, E H, Havekes, L M, Szalai, A J, Princen, H M.G, Emeis, J J

“…OBJECTIVE—C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development…”
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Combined analysis of pharmacokinetic and efficacy data of preclinical studies with statins markedly improves translation of drug efficacy to human trials by van de Steeg, E, Kleemann, R, Jansen, H T, van Duyvenvoorde, W, Offerman, E H, Wortelboer, H M, Degroot, J

“…Correct prediction of human pharmacokinetics (PK) and the safety and efficacy of novel compounds based on preclinical data, is essential but often fails. In…”
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Overexpression of fibrinogen in ApoE3-Leiden transgenic mice does not influence the progression of diet-induced atherosclerosis by Rezaee, F, Gijbels, M J, Offerman, E H, van der Linden, M, De Maat, M P M, Verheijen, J H

“…Although many epidemiological studies have shown an association between hyperfibrinogenemia and atherosclerosis, it is not established whether elevated…”
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Effect of Low Dose Atorvastatin Versus Diet-Induced Cholesterol Lowering on Atherosclerotic Lesion Progression and Inflammation in Apolipoprotein E3–Leiden Transgenic Mice by Verschuren, Lars, Kleemann, Robert, Offerman, Erik H, Szalai, Alexander J, Emeis, Sjef J, Princen, Hans M.G, Kooistra, Teake

“…OBJECTIVE—To evaluate whether low-dose atorvastatin suppresses atherosclerotic lesion progression and inflammation in apolipoprotein E*3 (apoE*3)–Leiden mice…”
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Acyl-CoA: cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE3-Leiden mice by DELSING, Dianne J. M, OFFERMAN, Erik H, VAN DUYVENVOORDE, Wim, VAN DER BOOM, Hans, DE WIT, Elly C. M, GIJBELS, Marion J. J, VAN DER LAARSE, Arnoud, J. WOUTER, JOUKEMA, HAVEKES, Louis M, PRINCEN, Hans M. G

“…The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden…”
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APOE 3Leiden . CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome by van den Hoek, A. M., van der Hoorn, J. W. A., Maas, A. C., van den Hoogen, R. M., van Nieuwkoop, A., Droog, S., Offerman, E. H., Pieterman, E. J., Havekes, L. M., Princen, H. M. G.

“…Aims This study aimed to investigate systematically (i) the appropriate dietary conditions to induce the features of the MetS in APOE * 3Leiden…”
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Absence of an atheroprotective effect of the garlic powder printanor in APOE3-Leiden transgenic mice by Santo, Sonia M.S. Espirito, Vlijmen, Bart J.M. van, Duyvenvoorde, Wim van, Offerman, Erik H., Havekes, Louis M., Arnault, Ingrid, Auger, Jacques, Princen, Hans M.G.

“…Numerous animal studies have reported that garlic can protect against atherosclerosis. However, a comparable number of studies do not support this observation…”
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