Search Results - "Offerhaus, GJ"

Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS) by van Heijl, M, van Lanschot, J J B, Koppert, L B, van Berge Henegouwen, M I, Muller, K, Steyerberg, E W, van Dekken, H, Wijnhoven, B P L, Tilanus, H W, Richel, D J, Busch, O R C, Bartelsman, J F, Koning, C C E, Offerhaus, G J, van der Gaast, A

“…A surgical resection is currently the preferred treatment for esophageal cancer if the tumor is considered to be resectable without evidence of distant…”
Get full text

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis by Cruz-Correa, Marcia, Hylind, Linda M., Marrero, Jessica Hernandez, Zahurak, Marianna L., Murray-Stewart, Tracy, Casero, Robert A., Montgomery, Elizabeth A., Iacobuzio-Donahue, Christine, Brosens, Lodewijk A., Offerhaus, G. Johan, Umar, Asad, Rodriguez, Luz M., Giardiello, Francis M.

“…Familial adenomatous polyposis is an autosomal dominant disorder characterized by the development of hundreds of colorectal adenomas and eventually colorectal…”
Get full text

Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett’s esophagus by Streppel, M M, Lata, S, DelaBastide, M, Montgomery, E A, Wang, J S, Canto, M I, Macgregor-Das, A M, Pai, S, Morsink, F H M, Offerhaus, G J, Antoniou, E, Maitra, A, McCombie, W R

“…The incidence of Barrett’s esophagus (BE)-associated esophageal adenocarcinoma (EAC) is increasing. Next-generation sequencing (NGS) provides an unprecedented…”
Get full text

Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions by HRUBAN, Ralph H, ADSAY, N. Volkan, LÜTTGES, Jutta, OFFERHAUS, G. Johan A, ALBORES-SAAVEDRA, Jorge, COMPTON, Carolyn, GARRETT, Elizabeth S, GOODMAN, Steven N, KERN, Scott E, KLIMSTRA, David S, KLÖPPEL, Günter, LONGNECKER, Daniel S

“…Proliferative epithelial lesions in the smaller caliber pancreatic ducts and ductules have been the subject of numerous morphologic, clinical, and genetic…”
Get full text

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation by van den Brink, Gijs R, Bleuming, Sylvia A, Hardwick, James C H, Schepman, Berber L, Offerhaus, G Johan, Keller, Josbert J, Nielsen, Corinne, Gaffield, William, van Deventer, Sander J H, Roberts, Drucilla J, Peppelenbosch, Maikel P

“…Wnt signaling defines the colonic epithelial progenitor cell phenotype, and mutations in the gene adenomatous polyposis coli (APC) that activate the Wnt…”
Get full text

Leptin Is a Growth Factor for Colonic Epithelial Cells by Hardwick, James C.H., Van Den Brink, Gijs R., Offerhaus, G.J., Van Deventer, Sander J.H., Peppelenbosch, Maikel P.

“…Background & Aims: Obesity increases the risk of colon cancer, whereas physical activity reduces the risk. Plasma levels of leptin increase in proportion to…”
Get full text

Multiple hyperplastic polyps in the stomach: Evidence for clonality and neoplastic potential by Dijkhuizen, SM, Entius, MM, Clement, MJ, Polak, MM, Van den Berg, FM, Craanen, ME, Slebos, RJ, Offerhaus, GJ

“…The origin and neoplastic potential of gastric epithelial polyps remains an area of great interest, and treatment choices are a topic of controversy. This…”
Get full text

Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER by Goggins, M, Offerhaus, GJ, Hilgers, W, Griffin, CA, Shekher, M, Tang, D, Sohn, TA, Yeo, CJ, Kern, SE, Hruban, RH

“…The clinical and pathological features of carcinomas of the pancreas with DNA replication errors (RER+) have not been characterized. Eighty-two xenografted…”
Get full text

Increased Cyclooxygenase-2 Expression in Duodenal Compared with Colonic Tissues in Familial Adenomatous Polyposis and Relationship to the −765G → C COX-2 Polymorphism by BROSENS, Lodewijk A. A, LACOBUZIO-DONAHUE, Christine A, KELLER, Josbert J, HUSTINX, Steven R, CARVALHO, Ralph, MORSINK, Folkert H, HYLIND, Linda M, OFFERHAUS, G. Johan, GIARDIELLO, Francis M, GOGGINS, Michael

“…Background: Colorectal cancers arising in patients with familial adenomatous polyposis (FAP) can be largely prevented by polyp surveillance and prophylactic…”
Get full text

Grading gastrointestinal dysplasia and what to call it when you don't know what it is by Offerhaus, GJ

“…Dysplasia in the gastrointestinal tract is defined as intraepithelial neoplasia (IEN) according to the WHO nomenclature. Neoplastic growth in the…”
Get full text

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps by HARDWICK, James C. H, VAN DEN BRINK, Gijs R, OFFERHAUS, G. J, VAN DEVENTER, Sander J. H, PEPPELENBOSCH, Maikel P

“…The factors that govern the progression from colonic adenomatous polyp to colon cancer are poorly understood. The observation that NSAIDs act as…”
Get full text

Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome by GRUBER, S. B, ENTIUS, M. M, VOGELSTEIN, B, HAMILTON, S. R, POLYMEROPOULOS, M. H, OFFERHAUS, G. J, GIARDIELLO, F. M, PETERSEN, G. M, LAKEN, S. J, LONGO, P. A, BOYER, R, LEVIN, A. M, MUJUMDAR, U. J, TRENT, J. M, KINZLER, K. W

“…Peutz-Jeghers syndrome (PJS) is an autosomal dominant condition characterized by intestinal hamartomatous polyps, mucocutaneous melanin deposition, and…”
Get full text

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization by Hruban, RH, van Mansfeld, AD, Offerhaus, GJ, van Weering, DH, Allison, DC, Goodman, SN, Kensler, TW, Bose, KK, Cameron, JL, Bos, JL

“…We examined 82 surgically resected or biopsied, formalin-fixed, paraffin-embedded primary adenocarcinomas of the pancreas for the presence of activating point…”
Get full text

Immunohistochemical and Genetic Analysis of Non–Small Cell and Small Cell Gallbladder Carcinoma and Their Precursor Lesions by Parwani, Anil V, Geradts, Joseph, Caspers, Eric, Offerhaus, G Johan, Yeo, Charles J, Cameron, John L, Klimstra, David S, Maitra, Anirban, Hruban, Ralph H, Argani, Pedram

“…Gallbladder carcinomas can be highly lethal neoplasms. Relatively little is known about the genetic abnormalities that underlie these tumors, particularly with…”
Get full text

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene by Van Nieuwkerk, CM, Elferink, RP, Groen, AK, Ottenhoff, R, Tytgat, GN, Dingemans, KP, Van Den Bergh Weerman, MA, Offerhaus, GJ

“…BACKGROUND & AIMS: The mouse mdr2 gene encodes a P-glycoprotein expressed in the hepatocanalicular membrane. Inactivation of this gene causes lack of biliary…”
Get full text

Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma by DiGiuseppe, JA, Hruban, RH, Offerhaus, GJ, Clement, MJ, van den Berg, FM, Cameron, JL, van Mansfeld, AD

“…Mutations in the K-ras oncogene and in the p53 tumor suppressor gene are commonly identified in sporadic cases of pancreatic adenocarcinoma. Although these…”
Get full text

Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid by van den Berg, FM, Baas, IO, Polak, MM, Offerhaus, GJ

“…With the aid of a newly developed target unmasking fluid (TUF), p53 overexpression was visualized by immunohistochemistry on recent and archival…”
Get full text

Increased risk of cancer in the Peutz-Jeghers syndrome by Giardiello, F M, Welsh, S B, Hamilton, S R, Offerhaus, G J, Gittelsohn, A M, Booker, S V, Krush, A J, Yardley, J H, Luk, G D

“…The Peutz-Jeghers syndrome is an autosomal dominant hereditary disease characterized by hamartomatous polyps of the gastrointestinal tract and by mucocutaneous…”
Get more information

Immunostaining of chain-specific keratins on formalin-fixed, paraffin- embedded tissues: a comparison of various antigen retrieval systems using microwave heating and proteolytic pre-treatments by Hazelbag, HM, van den Broek, LJ, van Dorst, EB, Offerhaus, GJ, Fleuren, GJ, Hogendoorn, PC

“…The use of chain-specific monoclonal antibodies (MAbs) against keratins in pathology is hampered by their limited staining on formalin-fixed, paraffin-embedded…”
Get full text

Molecular alterations in early gastric carcinomas : No apparent correlation with Helicobacter pylori status by BLOK, P, CRAANEN, M. E, OFFERHAUS, G. J, DEKKER, W, KUIPERS, E. J, MEUWISSEN, S. G, TYTGAT, G. N

“…Data on the differences in molecular profile between H pylori-positive and H pylori-negative early gastric carcinomas, if any, are almost nonexistent. We…”
Get full text