Search Results - "Offerhaus, G. Johan"

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening by Driehuis, Else, van Hoeck, Arne, Moore, Kat, Kolders, Sigrid, Francies, Hayley E., Gulersonmez, M. Can, Stigter, Edwin C. A., Burgering, Boudewijn, Geurts, Veerle, Gracanin, Ana, Bounova, Gergana, Morsink, Folkert H., Vries, Robert, Boj, Sylvia, van Es, Johan, Offerhaus, G. Johan A., Kranenburg, Onno, Garnett, Mathew J., Wessels, Lodewyk, Cuppen, Edwin, Brosens, Lodewijk A. A., Clevers, Hans

“…We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor…”
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A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas by Basturk, Olca, Hong, Seung-Mo, Wood, Laura D, Adsay, N Volkan, Albores-Saavedra, Jorge, Biankin, Andrew V, Brosens, Lodewijk A.A, Fukushima, Noriyoshi, Goggins, Michael, Hruban, Ralph H, Kato, Yo, Klimstra, David S, Klöppel, Günter, Krasinskas, Alyssa, Longnecker, Daniel S, Matthaei, Hanno, Offerhaus, G. Johan A, Shimizu, Michio, Takaori, Kyoichi, Terris, Benoit, Yachida, Shinichi, Esposito, Irene, Furukawa, Toru

“…International experts met to discuss recent advances and to revise the 2004 recommendations for assessing and reporting precursor lesions to invasive…”
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Gastric cancer: epidemiology, prevention, classification, and treatment by Sitarz, Robert, Skierucha, Małgorzata, Mielko, Jerzy, Offerhaus, G Johan A, Maciejewski, Ryszard, Polkowski, Wojciech P

“…Gastric cancer is the second most common cause of cancer-related deaths in the world, the epidemiology of which has changed within last decades. A trend of…”
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Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids by Fumagalli, Arianna, Drost, Jarno, Suijkerbuijk, Saskia J. E., van Boxtel, Ruben, de Ligt, Joep, Offerhaus, G. Johan, Begthel, Harry, Beerling, Evelyne, Tan, Ee Hong, Sansom, Owen J., Cuppen, Edwin, Clevers, Hans, van Rheenen, Jacco

“…In the adenoma-carcinoma sequence, it is proposed that intestinal polyps evolve through a set of defined mutations toward metastatic colorectal cancer (CRC)…”
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Degree and site of chromosomal instability define its oncogenic potential by Hoevenaar, Wilma H. M., Janssen, Aniek, Quirindongo, Ajit I., Ma, Huiying, Klaasen, Sjoerd J., Teixeira, Antoinette, van Gerwen, Bastiaan, Lansu, Nico, Morsink, Folkert H. M., Offerhaus, G. Johan A., Medema, René H., Kops, Geert J. P. L., Jelluma, Nannette

“…Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy…”
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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma by Cai, Jianqiang, Torbenson, Michael S, Kinzler, Kenneth W, Li, Meng, Zhao, Hong, Zhang, Xiaosong, Wood, Laura D, Anders, Robert A, Choti, Michael A, Pawlik, Timothy M, Daniel, Hubert D, Kannangai, Rajesh, Offerhaus, G Johan A, Velculescu, Victor E, Wang, Linfang, Zhou, Shibin, Vogelstein, Bert, Hruban, Ralph H, Papadopoulos, Nick

“…Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected…”
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Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases by Pea, Antonio, Yu, Jun, Marchionni, Luigi, Noe, Michael, Luchini, Claudio, Pulvirenti, Alessandra, de Wilde, Roeland F., Brosens, Lodewijk A., Rezaee, Neda, Javed, Ammar, Chianchiano, Peter, Gobbo, Stefano, Regi, Paolo, Salvia, Roberto, Bassi, Claudio, He, Jin, Weiss, Matthew J., Cameron, John L., Offerhaus, G. Johan A., Hruban, Ralph H., Lawlor, Rita T., Scarpa, Aldo, Heaphy, Christopher M., Wood, Laura D., Wolfgang, Christopher L.

“…OBJECTIVE:The aim of this study was to investigate the key molecular alterations in small primary pancreatic neuroendocrine tumors (PanNETs) associated with…”
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LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism by Jansen, Marnix, ten Klooster, Jean Paul, Offerhaus, G. Johan, Clevers, Hans

“…Hubrecht Institute, Developmental Biology and Stem Cell Research, and Department of Pathology, University Medical Centre, Utrecht; and Department of Pathology,…”
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Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK by Voorneveld, Philip W, Kodach, Liudmila L, Jacobs, Rutger J, Liv, Nalan, Zonnevylle, A. Christiaan, Hoogenboom, Jacob P, Biemond, Izak, Verspaget, Hein W, Hommes, Daniel W, de Rooij, Karien, van Noesel, Carel J.M, Morreau, Hans, van Wezel, Tom, Offerhaus, G. Johan A, van den Brink, Gijs R, Peppelenbosch, Maikel P, ten Dijke, Peter, Hardwick, James C.H

“…Background & Aims SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4…”
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Surgical and molecular pathology of pancreatic neoplasms by Hackeng, Wenzel M, Hruban, Ralph H, Offerhaus, G Johan A, Brosens, Lodewijk A A

“…Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the…”
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Status of CHEK2 and p53 in patients with early-onset and conventional gastric cancer by Machlowska, Julita, Kapusta, Przemysław, Szlendak, Małgorzata, Bogdali, Anna, Morsink, Folkert, Wołkow, Paweł, Maciejewski, Ryszard, Offerhaus, G Johan A, Sitarz, Robert

“…Gastric cancer (GC) is the fourth most common cause of cancer-associated death. Based on the age at diagnosis, GC is divided into early-onset GC (EOGC; ≤45…”
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Patients With Barrett’s Esophagus and Persistent Low-grade Dysplasia Have an Increased Risk for High-grade Dysplasia and Cancer by Kestens, Christine, Offerhaus, G. Johan A, van Baal, Jantine W.P.M, Siersema, Peter D

“…Background & Aims In some patients with Barrett’s esophagus (BE) and a confirmed diagnosis of low-grade dysplasia (LGD), the LGD is not detected during…”
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Patients With Barrett’s Esophagus and Confirmed Persistent Low-Grade Dysplasia Are at Increased Risk for Progression to Neoplasia by Duits, Lucas C, van der Wel, M.J, Cotton, Cary C, Phoa, K. Nadine, ten Kate, Fiebo J.W, Seldenrijk, Cees A, Offerhaus, G. Johan A, Visser, Mike, Meijer, Sybren L, Mallant-Hent, Rosalie C, Krishnadath, Kausilia K, Pouw, Roos E, Tijssen, Jan G.P, Shaheen, Nicholas J, Bergman, Jacques J.G.H.M

“…Background & Aims For patients with Barrett’s esophagus, the diagnosis of low-grade dysplasia (LGD) is subjective, and reported outcomes vary. We analyzed data…”
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Ligand-dependent Notch Signaling Is Involved in Tumor Initiation and Tumor Maintenance in Pancreatic Cancer by MULLENDORE, Michael E, KOORSTRA, Jan-Bart, LI, Yue-Ming, JOHAN OFFERHAUS, G, XING FAN, HENDERSON, Clark M, MATSUI, William, EBERHART, Charles G, MAITRA, Anirban, FELDMANN, Georg

“…Purpose: Aberrant activation of the Notch signaling pathway is commonly observed in human pancreatic cancer, although the mechanism(s) for this activation has…”
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Classification of types of intraductal papillary-mucinous neoplasm of the pancreas : a consensus study by FURUKAWA, Toru, KLÖPPEL, Günter, LÜTTGES, Jutta, OFFERHAUS, G. Johan A, SHIMIZU, Michio, SUNAMURA, Makoto, SURIAWINATA, Arief, TAKAORI, Kyoichi, YONEZAWA, Suguru, ADSAY, N. Volkan, ALBORES-SAAVEDRA, Jorge, FUKUSHIMA, Noriyoshi, HORII, Akira, HRUBAN, Ralph H, KATO, Yo, KLIMSTRA, David S, LONGNECKER, Daniel S

“…Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists…”
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BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2 by Kestens, Christine, Siersema, Peter D, Offerhaus, G Johan A, van Baal, Jantine W P M

“…Bone morphogenetic protein 4 (BMP4) signaling is involved in the development of Barrett's esophagus (BE), a precursor of esophageal adenocarcinoma (EAC). In…”
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Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research by Tetteh, Paul W., Kretzschmar, Kai, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, Morsink, Folkert, Farin, Henner, van Es, Johan H., Offerhaus, G. Johan A., Clevers, Hans

“…Current mouse models for colorectal cancer often differ significantly from human colon cancer, being largely restricted to the small intestine. Here, we aim to…”
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De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine by Haramis, Anna-Pavlina G., Begthel, Harry, van den Born, Maaike, van Es, Johan, Jonkheer, Suzanne, G. Johan A. Offerhaus, Clevers, Hans

“…Little is known about the signaling mechanisms that determine the highly regular patterning of the intestinal epithelium into crypts and villi. With the use of…”
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Why is pancreatic cancer so deadly? The pathologist's view by Hruban, Ralph H, Gaida, Matthias M, Thompson, Elizabeth, Hong, Seung‐Mo, Noë, Michaël, Brosens, Lodewijk AA, Jongepier, Martine, Offerhaus, G Johan A, Wood, Laura D

“…The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a…”
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Molecular alterations in gastric cancer with special reference to the early-onset subtype by Skierucha, Małgorzata, Milne, Anya Na, Offerhaus, G Johan A, Polkowski, Wojciech P, Maciejewski, Ryszard, Sitarz, Robert

“…Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause…”
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