Search Results - "Offensperger, Fabian"

Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex by Sailer, Carolin, Offensperger, Fabian, Julier, Alexandra, Kammer, Kai-Michael, Walker-Gray, Ryan, Gold, Matthew G., Scheffner, Martin, Stengel, Florian

“…Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein…”
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A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome by Yao, Zhong, Darowski, Katelyn, St-Denis, Nicole, Wong, Victoria, Offensperger, Fabian, Villedieu, Annabel, Amin, Shahreen, Malty, Ramy, Aoki, Hiroyuki, Guo, Hongbo, Xu, Yang, Iorio, Caterina, Kotlyar, Max, Emili, Andrew, Jurisica, Igor, Neel, Benjamin G., Babu, Mohan, Gingras, Anne-Claude, Stagljar, Igor

“…Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein…”
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Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation by Kagiou, Chrysanthi, Cisneros, Jose A., Farnung, Jakob, Liwocha, Joanna, Offensperger, Fabian, Dong, Kevin, Yang, Ka, Tin, Gary, Horstmann, Christina S., Hinterndorfer, Matthias, Paulo, Joao A., Scholes, Natalie S., Sanchez Avila, Juan, Fellner, Michaela, Andersch, Florian, Hannich, J. Thomas, Zuber, Johannes, Kubicek, Stefan, Gygi, Steven P., Schulman, Brenda A., Winter, Georg E.

“…Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the…”
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Cobalamins Function as Allosteric Activators of an Angelman Syndrome‐Associated UBE3A/E6AP Variant by Müller, Franziska, Jansen, Jasmin, Offensperger, Fabian, Eichbichler, Daniela, Stengel, Florian, Scheffner, Martin

“…Genetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder…”
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Fluorescently Labelled ATP Analogues for Direct Monitoring of Ubiquitin Activation by Hammler, Daniel, Stuber, Katrin, Offensperger, Fabian, Scheffner, Martin, Zumbusch, Andreas, Marx, Andreas

“…Simple and robust assays to monitor enzymatic ATP cleavage with high efficiency in real‐time are scarce. To address this shortcoming, we developed…”
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Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling by Ng, Amanda, Offensperger, Fabian, Cisneros, Jose A., Scholes, Natalie S., Malik, Monika, Villanti, Ludovica, Rukavina, Andrea, Ferrada, Evandro, Hannich, J. Thomas, Koren, Anna, Kubicek, Stefan, Superti-Furga, Giulio, Winter, Georg E.

“…Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiquitin–proteasome system. While MGDs were historically…”
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Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells by Offensperger, Fabian, Tin, Gary, Duran-Frigola, Miquel, Hahn, Elisa, Dobner, Sarah, Ende, Christopher W Am, Strohbach, Joseph W, Rukavina, Andrea, Brennsteiner, Vincenth, Ogilvie, Kevin, Marella, Nara, Kladnik, Katharina, Ciuffa, Rodolfo, Majmudar, Jaimeen D, Field, S Denise, Bensimon, Ariel, Ferrari, Luca, Ferrada, Evandro, Ng, Amanda, Zhang, Zhechun, Degliesposti, Gianluca, Boeszoermenyi, Andras, Martens, Sascha, Stanton, Robert, Müller, André C, Hannich, J Thomas, Hepworth, David, Superti-Furga, Giulio, Kubicek, Stefan, Schenone, Monica, Winter, Georg E

“…Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of…”
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FAT10 and NUB1L cooperate to activate the 26S proteasome by Brockmann, Florian, Catone, Nicola, Wünsch, Christine, Offensperger, Fabian, Scheffner, Martin, Schmidtke, Gunter, Aichem, Annette

“…The interaction of the 19S regulatory particle of the 26S proteasome with ubiquitylated proteins leads to gate opening of the 20S core particle and increases…”
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