Limb sparing approach: Adjuvant radiation therapy in adults with intermediate or high-grade limb soft tissue sarcoma

Limb sparing approach: Adjuvant radiation therapy in adults with intermediate or high-grade limb soft tissue sarcoma

Limb soft tissue sarcomas (STS) are currently treated with limb sparing surgery (LSS) followed by radiation therapy (RT). Between October 1994 and October 2002, 133 adult patients with intermediate or high-grade limb STS were approached by LSS+RT. RT related toxicity was manageable, with a low rate...

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Bibliographic Details
Published in:Radiotherapy and oncology Vol. 77; no. 3; pp. 295 - 300
Main Authors: Merimsky, Ofer, Soyfer, Vjacheslav, Kovner, Felix, Bickels, Jacob, Issakov, Josephine, Flusser, Gideon, Meller, Isaac, Ofer, Oded, Kollender, Yehuda
Format: Journal Article
Language:English
Published: Ireland Elsevier Ireland Ltd 01-12-2005
Subjects:
Adjuvant radiation therapy
Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Female
Humans
Limb
Limb Salvage
Limb sparing approach
Male
Middle Aged
Radiotherapy, Adjuvant
Radiotherapy, Conformal
Sarcoma - pathology
Sarcoma - radiotherapy
Sarcoma - surgery
Soft tissue sarcoma
Treatment Outcome
Limb sparing approach
Soft tissue sarcoma
Adult
Adjuvant radiation therapy
Limb
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Summary:Limb soft tissue sarcomas (STS) are currently treated with limb sparing surgery (LSS) followed by radiation therapy (RT). Between October 1994 and October 2002, 133 adult patients with intermediate or high-grade limb STS were approached by LSS+RT. RT related toxicity was manageable, with a low rate of severe effects. At 4-year median follow-up, there were 48 recurrences of any type, 23 of isolated local failure, and 35 of systemic spread w/o local failure. DFS and OS were influenced by disease stage II vs I, primary site in the upper limb vs lower limb, MPNST vs other types, induction therapy vs no induction, adequate resection vs marginal resection or involved margins, and good response to induction therapy vs bad response. DFS and OS were Patient's age and sex, tumor depth, acute or late toxicity of RT, or the interval of time between the date of definitive surgery and the start of RT did not affect DFS and or OS. The RT protocol is applicable in the era of complicated, expensive and time-consuming 3D therapy. Our results of LSS+RT in adults with limb HG STS are satisfactory.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2005.10.019