Search Results - "Ofarrill, Eliud Hernandez"

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer by Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Hernandez-O'Farrill, Eliud, Borrero-Garcia, Luis D, Forestier-Roman, Ingrid, Gerena, Yamil, Blanco, Manuel, Rivera-Robles, Michael J, Rodriguez-Medina, José R, Cubano, Luis A, Vlaar, Cornelis P, Dharmawardhane, Suranganie

“…The Rho GTPases Rac (Ras-related C3 botulinum toxin substrate) and Cdc42 (cell division control protein 42 homolog) regulate cell functions governing cancer…”
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Efficacy and delivery strategies of the dual Rac/Cdc42 inhibitor MBQ-167 in HER2 overexpressing breast cancer by Velázquez-Vega, Luis E., Rivera-Robles, Michael, Sánchez-Álvarez, Annelis O., Vivas-Mejía, Pablo E., Aponte-Reyes, Miciely, Cruz-Collazo, Ailed M., Grafals-Ruiz, Nilmary, Dorta-Estremera, Stephanie, Hernández-O'Farrill, Eliud, Vlaar, Cornelis P, Dharmawardhane, Suranganie

“…•The results presented herein demonstrate that free and liposomal MBQ-167 reduces cell viability, inhibit tumor growth, and decreases metastasis to lungs and…”
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Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry by Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Corujo-Carro, Francheska, Duconge, Jorge, Hernandez-O’Farrill, Eliud, Vlaar, Cornelis, Rodriguez-Orengo, Jose F., Cubano, Luis, Dharmawardhane, Suranganie

“…•A rapid and sensitive method was validated for detection of EHop-016 in mouse plasma by UPLC/MS/MS.•EHop-016 pharmacokinetics in mice was quantified using a…”
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Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry by Maldonado, María del Mar, Rosado-González, Gabriela, Bloom, Joseph, Duconge, Jorge, Ruiz-Calderón, Jean F, Hernández-O’Farrill, Eliud, Vlaar, Cornelis, Rodríguez-Orengo, José F, Dharmawardhane, Suranganie

“…The Rho GTPases Rac and Cdc42 are potential targets against metastatic diseases. We characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42…”
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The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer by Crespo, Grace Velez, Ortiz, Jescelica, O'Farrill, Eliud Hernández, Vlaar, Cornelis P, Inyushin, Mikhail, Kucheryavykh, Yuriy, Kucheryavykh, Lilia

“…The significant challenge in treating triple-negative breast cancer (TNBC) lies in its high rate of distant metastasis. To address this, inhibiting metastasis…”
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Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer by Cruz-Collazo, Ailed, Ruiz-Calderon, Jean F, Picon, Hector, Borrero-Garcia, Luis D, Lopez, Irmaris, Castillo-Pichardo, Linette, Del Mar Maldonado, Maria, Duconge, Jorge, Medina, Julia I, Bayro, Marvin J, Hernández-O'Farrill, Eliud, Vlaar, Cornelis P, Dharmawardhane, Suranganie

“…Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer, with a high predisposition for locally invasive and metastatic cancer. With the…”
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Targeting Lipocalin-2 in Inflammatory Breast Cancer Cells with Small Interference RNA and Small Molecule Inhibitors by Santiago-Sánchez, Ginette S, Noriega-Rivera, Ricardo, Hernández-O'Farrill, Eliud, Valiyeva, Fatma, Quiñones-Diaz, Blanca, Villodre, Emilly S, Debeb, Bisrat G, Rosado-Albacarys, Andrea, Vivas-Mejía, Pablo E

“…Inflammatory Breast Cancer (IBC) is an aggressive form of invasive breast cancer, highly metastatic, representing 2-4% of all breast cancer cases in the United…”
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Abstract 3251: Characterization of a novel Rac inhibitor as an anti cancer metastasis compound by Ortiz, Brendaliz Montalvo, Ofarrill, Eliud Hernandez, Hernandez, Jonibeth, Vlaar, Cornelis, Flanagan, Surangani Dharmawardhane

“…The objective of this project is to design novel therapeutics targeting cancer metastasis, the most deadly aspect of epithelial cancers. Our previous studies…”
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Abstract 4923: Pharmacokinetics of the metastatic cancer inhibitor MBQ-167 in mice by Maldonado, Maria del Mar, Castillo-Pichardo, Linette, Bloom, Joseph, Duconge, Jorge, Rodriguez-Orengo, Jose F., Hernandez-O'Farrill, Eliud, Vlaar, Cornelis, Dharmawardhane, Suranganie

“…Metastasis is the principal cause of death for most cancer patients; however, effective treatment options are limited. The Rho GTPases Rac and Cdc42 are…”
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Supercritical Fluid Chromatography‐Tandem Mass Spectrometry Method Development for the Detection of the Rac/Cdc42 inhibitor MBQ‐167 in Mouse Plasma by del Mar Maldonado, Maria, Bloom, Joseph, Hernandez‐O'Farrill, Eliud, Vlaar, Cornelis, Rodriguez‐Orengo, Jose F, Dharmawardhane, Suranganie

“…Abstract only Metastasis is the principal cause of death for most cancer patients; however, effective treatment options are limited. Targeting pivotal…”
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Abstract A141: A novel inhibitor of malignant signaling in metastatic breast cancer by Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Borrero-Garcia, Luis, Forestier-Roman, Ingrid, Cubano, Luis, Hernandez-O'Farrill, Eliud, Vlaar, Cornelis, Dharmawardhane, Suranganie

“…The Rho GTPase Rac is a pivotal regulator of cancer cell migration and invasion; processes required for metastatic progression. We previously characterized the…”
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Determination of Rac inhibitor Ehop‐016 in mouse plasma by ultra‐performance liquid chromatography tandem mass spectrometry (987.2) by Humphries‐Bickley, Tessa, Corujo, Francheska, Castillo‐Pichardo, Linette, Hernandez‐O'Farrill, Eliud, Vlaar, Cornelis, Rodriguez‐Orengo, Jose, Dharmawardhane, Suranganie

“…The Rho GTPase Rac is an important regulator of cancer cell migration and cell invasion; processes required for metastatic progression. We previously…”
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Abstract 4473: Targeting matrix metalloproteinase-3 (MMP-3) in high-grade serous ovarian cancer by Reyes-Burgos, Víctor G., Hernández-O'Farrill, Eliud, Quiñones, Luis E. Vazquez, Flores-Colón, Marienid, Valiyeva, Fatima, Vivas-Mejía, Pablo E.

“…High-Grade Serous Ovarian Cancer (HGSOC) is the most aggressive and lethal gynecological malignancy. Surgery and chemotherapy (with platinum compounds) are the…”
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