Search Results - "Oevermann, Lena"

Lower incidence of grade II-IV acute Graft-versus-Host-Disease in pediatric patients recovering with high Vδ2+ T cells after allogeneic stem cell transplantation with unmanipulated bone marrow grafts: a prospective single-center cohort study by Müller, Thilo, Alasfar, Lina, Preuß, Friederike, Zimmermann, Lisa, Streitz, Mathias, Hundsdörfer, Patrick, Eggert, Angelika, Schulte, Johannes, von Stackelberg, Arend, Oevermann, Lena

“…Gamma delta (γδ) T cells represent a minor fraction of human T cell repertoire but play an important role in mediating anti-infectious and anti-tumorous…”
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Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B-cell impairment and increases the risk for infections - a retrospective matched cohort study by Launspach, Michael, Temel, Dennis, Ohlendorf, Emily, Zirngibl, Felix, Materne, Bianca, Oevermann, Lena, Deubzer, Hedwig E, Henssen, Anton G, Künkele, Annette, Hundsdörfer, Patrick, Bernuth, Horst von, Pruß, Axel, Eggert, Angelika, Stackelberg, Arend von, Lang, Peter, Schulte, Johannes H

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Genetic modifiers of fetal hemoglobin affect the course of sickle cell disease in patients treated with hydroxyurea by Allard, Pierre, Alhaj, Nareen, Lobitz, Stephan, Cario, Holger, Jarisch, Andreas, Grosse, Regine, Oevermann, Lena, Hakimeh, Dani, Tagliaferri, Laura, Kohne, Elisabeth, Kopp-Schneider, Annette, Kulozik, Andreas E., Kunz, Joachim B.

“…The course of sickle cell disease (SCD) is modified by polymorphisms boosting fetal hemoglobin (HbF) synthesis. However, it has remained an open question how…”
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Donor selection in a pediatric stem cell transplantation cohort using PIRCHE and HLA‐DPB1 typing by Stenger, Wiebke, Künkele, Annette, Niemann, Matthias, Todorova, Kremena, Pruß, Axel, Schulte, Johannes H., Eggert, Angelika, Oevermann, Lena

“…Background New strategies to optimize donor selection for hematopoietic stem cell transplantation (HSCT) have mainly been evaluated in adults, but the disease…”
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Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4 + CAR T Cell Efficacy by Ali, Solin, Toews, Karin, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Grunewald, Laura, Oevermann, Lena, Deubzer, Hedwig E, Tüns, Alicia, Jensen, Michael C, Henssen, Anton G, Eggert, Angelika, Schulte, Johannes H, Schwich, Esther, Rebmann, Vera, Schramm, Alexander, Künkele, Annette

“…Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived…”
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Presence of centromeric but absence of telomeric group B KIR haplotypes in stem cell donors improve leukaemia control after HSCT for childhood ALL by Babor, Florian, Peters, Christina, Manser, Angela R., Glogova, Evgenia, Sauer, Martin, Pötschger, Ulrike, Ahlmann, Martina, Cario, Gunnar, Feuchtinger, Tobias, Gruhn, Bernd, Güngör, Tayfun, Horn, Peter A., Kremens, Bernhard, Lang, Peter, Mezger, Markus, Müller, Ingo, Mytilineos, Joannis, Oevermann, Lena, Pichler, Herbert, Scherenschlich, Nadine, Schuster, Friedhelm R., Siepermann, Meinolf, Stachel, Daniel, Strahm, Brigitte, Wössmann, Wilhelm, Escherich, Gabriele, Zimmermann, Martin, Schrappe, Martin, Borkhardt, Arndt, Eckert, Cornelia, Bader, Peter, Uhrberg, Markus, Meisel, Roland

“…Although allogeneic hematopoietic stem-cell transplantation (HSCT) provides high cure rates for children with high-risk acute lymphoblastic leukaemia (ALL),…”
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Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications by Oevermann, Lena, Zimmermann, Cosima, Voigt, Sebastian, Künkele, Annette, Lobitz, Stephan, Eggert, Angelika, Schulte, Johannes H., Kaufer, Benedikt B., Deubzer, Hedwig E.

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Introduction of Universal Newborn Screening for Sickle Cell Disease in Germany-A Brief Narrative Review by Lobitz, Stephan, Kunz, Joachim B, Cario, Holger, Hakimeh, Dani, Jarisch, Andrea, Kulozik, Andreas E, Oevermann, Lena, Grosse, Regine

“…Sickle cell disease (SCD) is a severe non-malignant disorder of hemoglobin and is inherited in an autosomal-recessive manner [...]…”
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Both mature KIR+ and immature KIR− NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice by Kübler, Ayline, Woiterski, Jeanette, Witte, Kai-Erik, Bühring, Hans-Jörg, Hartwig, Udo F., Ebinger, Martin, Oevermann, Lena, Mezger, Markus, Herr, Wolfgang, Lang, Peter, Handgretinger, Rupert, Münz, Christian, André, Maya C.

“…Therapeutic natural killer (NK)-cell–mediated alloreactivity toward acute myeloid leukemia has largely been attributed to mismatches between killer…”
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New strategies for haploidentical transplantation by Oevermann, Lena, Handgretinger, Rupert

“…Haploidentical transplantation in children opens the possibility to offer this treatment to every child with an otherwise incurable disease, such as some…”
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KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL by Oevermann, Lena, Michaelis, Sebastian U., Mezger, Markus, Lang, Peter, Toporski, Jacek, Bertaina, Alice, Zecca, Marco, Moretta, Lorenzo, Locatelli, Franco, Handgretinger, Rupert

“…We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free…”
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Establishing Standard of Care in Predicting Serious Complications for Patients Planned to Undergo Allogenic Hematopeotic Stem Cell Transplantation by Reschke, Madlen, Gross, Jonathan P., Hegner, Janina, Seiler, Jonas, Sürücü, Gülüstan, Penack, Olaf, Weschke, Daniel, Higgins, David, Oevermann, Lena

“…Background: There is no reliable way to predict the individual risk of suffering from relevant complications during the course of Hematopoetic Stem Cell…”
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Artificial Intelligence (AI) Based, Machine Learning (ML) Predicting the Individual Absolute Risk of Acute Graft Versus Host Disease (aGvHD) in a Retrospective International Cohort by Reschke, Madlen, Gross, Jonathan P., Penack, Olaf, Sürücü, Gülüstan, Summers, Corinne, Seiler, Jonas, Weschke, Daniel, Higgins, David, Oevermann, Lena

“…Background: HSCT still holds potentially lethal complications such as aGvHD, relapse of malignant disease, graft rejection, and infections. 30 to 50% of all…”
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Real‐Life experience with hydroxyurea in patients with sickle cell disease: Results from the prospective ESCORT‐HU cohort study by Montalembert, Mariane, Voskaridou, Ersi, Oevermann, Lena, Cannas, Giovanna, Habibi, Anoosha, Loko, Gylna, Joseph, Laure, Colombatti, Raffaella, Bartolucci, Pablo, Brousse, Valentine, Galactéros, Frédéric

“…Several controlled studies have evidenced good efficacy and short‐term and mid‐term safety profiles for hydroxyurea (HU), which has become the cornerstone for…”
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Hydroxyurea Is Associated with Later Onset of Occurrence of Acute Splenic Sequestration Episodes in Sickle Cell Disease: Lessons from the European Sickle Cell Disease Cohort - Hydroxyurea (ESCORT-HU) Study by de Montalembert, Mariane, Galactéros, Frédéric, Oevermann, Lena, Cannas, Giovanna, Joseph, Laure, Loko, Gylna, Elenga, Narcisse, Benkerrou, Malika, Etienne-Julan, Maryse, Castex, Marie-Pierre, Grosse, Regine, Brousse, Valentine

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Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma by Lodrini, Marco, Graef, Josefine, Thole-Kliesch, Theresa M, Astrahantseff, Kathy, Sprüssel, Annika, Grimaldi, Maddalena, Peitz, Constantin, Linke, Rasmus B, Hollander, Jan F, Lankes, Erwin, Künkele, Annette, Oevermann, Lena, Schwabe, Georg, Fuchs, Jörg, Szymansky, Annabell, Schulte, Johannes H, Hundsdörfer, Patrick, Eckert, Cornelia, Amthauer, Holger, Eggert, Angelika, Deubzer, Hedwig E

“…Treating refractory or relapsed neuroblastoma remains challenging. Monitoring body fluids for tumor-derived molecular information indicating minimal residual…”
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HLA-haploidentical hematopoietic stem cell transplantation in pediatric patients with hemoglobinopathies: current practice and new approaches by Oevermann, Lena, Schulte, Johannes H., Hundsdörfer, Patrick, Hakimeh, Dani, Kogel, Friederike, Lang, Peter, Corbacioglu, Selim, Eggert, Angelika, Sodani, Pietro

“…We review current approaches in HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for pediatric patients with hemoglobinopathies with a…”
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Benefits of a Disease Management Program for SCD in Germany 2011 - 2019: The Increased Use of Hydroxyurea Correlates with a Reduced Frequency of Acute Chest Syndrome by Kunz, Joachim B., Schlotmann, Andreas, Daubenbüchel, Andrea, Lobitz, Stephan, Jarisch, Andrea, Grosse, Regine, Cario, Holger, Oevermann, Lena, Hakimeh, Dani, Tagliaferri, Laura, Kulozik, Andreas E.

“…Background Worldwide, Sickle Cell Disease (SCD) is the most common single gene disorder affecting >250,000 newborns annually. In Germany, SCD qualifies as a…”
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Implementation of Escort-HU Extension: European Sickle Cell Disease Cohort - Hydroxyurea - Extension Study : Interests and Methodology by de Montalembert, Mariane, Voskaridou, Ersi, Oevermann, Lena, Cannas, Giovanna, Habibi, Anoosha, Loko, Gylna, Joseph, Laure, Colombatti, Raffaella, Bartolucci, Pablo, Brousse, Valentine, Galactéros, Frédéric

“…The efficacy and long-term effectiveness of hydroxycarbamide/hydroxyurea (HU) in the prevention of painful crises and in the decrease of mortality and…”
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Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells by Lareau, Caleb A., Dubois, Sonia M., Buquicchio, Frank A., Hsieh, Yu-Hsin, Garg, Kopal, Kautz, Pauline, Nitsch, Lena, Praktiknjo, Samantha D., Maschmeyer, Patrick, Verboon, Jeffrey M., Gutierrez, Jacob C., Yin, Yajie, Fiskin, Evgenij, Luo, Wendy, Mimitou, Eleni P., Muus, Christoph, Malhotra, Rhea, Parikh, Sumit, Fleming, Mark D., Oevermann, Lena, Schulte, Johannes, Eckert, Cornelia, Kundaje, Anshul, Smibert, Peter, Vardhana, Santosha A., Satpathy, Ansuman T., Regev, Aviv, Sankaran, Vijay G., Agarwal, Suneet, Ludwig, Leif S.

“…Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism, contributing to cellular heterogeneity and disease. Diverse mutations are…”
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