Search Results - "Oetting, William S."

Polygenic risk score for acute rejection based on donor-recipient non-HLA genotype mismatch by Cao, Rui, Schladt, David P, Dorr, Casey, Matas, Arthur J, Oetting, William S, Jacobson, Pamala A, Israni, Ajay, Chen, Jinbo, Guan, Weihua

“…Acute rejection (AR) after kidney transplantation is an important allograft complication. To reduce the risk of post-transplant AR, determination of kidney…”
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NPHP1 (Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD by Snoek, Rozemarijn, van Setten, Jessica, Keating, Brendan J, Israni, Ajay K, Jacobson, Pamala A, Oetting, William S, Matas, Arthur J, Mannon, Roslyn B, Zhang, Zhongyang, Zhang, Weijia, Hao, Ke, Murphy, Barbara, Reindl-Schwaighofer, Roman, Heinzl, Andreas, Oberbauer, Rainer, Viklicky, Ondrej, Conlon, Peter J, Stapleton, Caragh P, Bakker, Stephan J L, Snieder, Harold, Peters, Edith D J, van der Zwaag, Bert, Knoers, Nine V A M, de Borst, Martin H, van Eerde, Albertien M

“…Nephronophthisis (NPH) is the most prevalent genetic cause for ESRD in children. However, little is known about the prevalence of NPH in adult-onset ESRD…”
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Dosing equation for tacrolimus using genetic variants and clinical factors by Passey, Chaitali, Birnbaum, Angela K., Brundage, Richard C., Oetting, William S., Israni, Ajay K., Jacobson, Pamala A.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Patients with low tacrolimus troughs are at a higher risk of rejection while those with high troughs are at an…”
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Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: A comparison of four ancestry groups by Mohamed, Moataz E., Schladt, David P., Guan, Weihua, Wu, Baolin, Setten, Jessica, Keating, Brendan J., Iklé, David, Remmel, Rory P., Dorr, Casey R., Mannon, Roslyn B., Matas, Arthur J., Israni, Ajay K., Oetting, William S., Jacobson, Pamala A., Cecka, J. Michael, Connett, John, Cosio, Fernando G., Gaston, Robert, Gourishankar, Sita, Grande, Joseph P., Hunsicker, Lawrence, Kasiske, Bertram, Rush, David

“…Tacrolimus trough and dose requirements vary dramatically between individuals of European and African American ancestry. These differences are less well…”
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A Genome-Wide Association Study of Behavioral Disinhibition by McGue, Matt, Zhang, Yiwei, Miller, Michael B., Basu, Saonli, Vrieze, Scott, Hicks, Brian, Malone, Steve, Oetting, William S., Iacono, William G.

“…We report results from a genome wide association study (GWAS) of five quantitative indicators of behavioral disinhibition: nicotine, alcohol consumption,…”
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The Human Genome Organisation (HUGO) and a vision for Ecogenomics: the Ecological Genome Project by Capps, Benjamin, Chadwick, Ruth, Lederman, Zohar, Lysaght, Tamra, Mills, Catherine, Mulvihill, John J, Oetting, William S, Winship, Ingrid

“…The following outlines ethical reasons for widening the Human Genome Organisation's (HUGO) mandate to include ecological genomics. MAIN: The environment…”
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Tacrolimus trough and dose intra‐patient variability and CYP3A5 genotype: Effects on acute rejection and graft failure in European American and African American kidney transplant recipients by Seibert, Stephan R., Schladt, David P., Wu, Baolin, Guan, Weihua, Dorr, Casey, Remmel, Rory P., Matas, Arthur J., Mannon, Roslyn B., Israni, Ajay K., Oetting, William S., Jacobson, Pamala A.

“…Background Suboptimal immunosuppression after kidney transplantation contributes to toxicity and loss of efficacy. Little is known regarding the impact of…”
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Meeting the New AACP Competencies in Genetics and Clinical Pharmacogenomics at the University of Minnesota by Brown, Jacob T, Sorge, Lindsay A, Oetting, William S, Jacobson, Pamala A, Pereira, Chrystian

“…: Pharmacogenomics (PGx) is increasingly being used for creating individualized treatments for patient care. Healthcare professionals, especially pharmacists,…”
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Functional Fcgamma receptor polymorphisms are associated with human allergy by Wu, Jianming, Lin, Rui, Huang, Jinhai, Guan, Weihua, Oetting, William S, Sriramarao, P, Blumenthal, Malcolm N

“…IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of…”
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A Multi-Marker Test for Analyzing Paired Genetic Data in Transplantation by Arthur, Victoria L, Li, Zhengbang, Cao, Rui, Oetting, William S, Israni, Ajay K, Jacobson, Pamala A, Ritchie, Marylyn D, Guan, Weihua, Chen, Jinbo

“…Emerging evidence suggests that donor/recipient matching in non-HLA (human leukocyte antigen) regions of the genome may impact transplant outcomes and…”
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High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions by Fang, Gang, Haznadar, Majda, Wang, Wen, Yu, Haoyu, Steinbach, Michael, Church, Timothy R, Oetting, William S, Van Ness, Brian, Kumar, Vipin

“…There has been increased interest in discovering combinations of single-nucleotide polymorphisms (SNPs) that are strongly associated with a phenotype even if…”
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Multigene predictors of tacrolimus exposure in kidney transplant recipients by Pulk, Rebecca A, Schladt, David S, Oetting, William S, Guan, Weihua, Israni, Ajay K, Matas, Arthur J, Remmel, Rory P, Jacobson, Pamala A

“…Determine the effect of the genetic variants beyond CYP3A5*3 on tacrolimus disposition. We studied genetic correlates of tacrolimus trough concentrations with…”
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The Minnesota Center for Twin and Family Research Genome-Wide Association Study by Miller, Michael B., Basu, Saonli, Cunningham, Julie, Eskin, Eleazar, Malone, Steven M., Oetting, William S., Schork, Nicholas, Sul, Jae Hoon, Iacono, William G., McGue, Matt

“…As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association…”
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Tacrolimus trough levels after month 3 as a predictor of acute rejection following kidney transplantation: a lesson learned from DeKAF Genomics by Israni, Ajay K, Riad, Samy M, Leduc, Robert, Oetting, William S, Guan, Weihua, Schladt, David, Matas, Arthur J, Jacobson, Pamala A

“…Most calcineurin inhibitor (CNI)-based protocols reduce blood trough goals approximately 2-3 months post-transplant in clinically stable kidney transplant…”
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Impact of next generation sequencing: The 2009 Human Genome Variation Society Scientific Meeting by Oetting, William S

“…The annual scientific meeting of the Human Genome Variation Society (HGVS) was held on the 20th of October, 2009, in Honolulu, Hawaii. The theme of this…”
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Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients by Dorr, Casey, Wu, Baolin, Guan, Weihua, Muthusamy, Amutha, Sanghavi, Kinjal, Schladt, David P, Maltzman, Jonathan S, Scherer, Steven E, Brott, Marcia J, Matas, Arthur J, Jacobson, Pamala A, Oetting, William S, Israni, Ajay K

“…We performed RNA sequencing (RNAseq) on peripheral blood mononuclear cells (PBMCs) to identify differentially expressed gene transcripts (DEGs) after kidney…”
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Genetic Determinants of Mycophenolate-Related Anemia and Leukopenia After Transplantation by JACOBSON, Pamala A, SCHLADT, David, OETTING, William S, LEDUC, Robert, WEIHAU GUAN, MATAS, Arthur J, LANUBA, Vishal, MANNON, Roslyn B, JULIAN, Bruce A, ISRANI, Ajay

“…Mycophenolate-related anemia and leukopenia are well-known toxicities after transplantation. Toxicity leads to dose reduction, addition of colony-stimulating…”
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Variations in the Catechol O-methyltransferase Polymorphism and Prefrontally Guided Behaviors in Adolescents by Wahlstrom, Dustin, White, Tonya, Hooper, Catalina J, Vrshek-Schallhorn, Suzanne, Oetting, William S, Brott, Marcia J, Luciana, Monica

“…Background The catechol-O-methyltransferase (COMT) gene codes for an enzyme that degrades prefrontal cortex (PFC) synaptic dopamine. Of two identified alleles…”
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Tyrosinase gene mutations in oculocutaneous albinism 1 (OCA1): definition of the phenotype by KING, Richard A, PIETSCH, Jacy, FRYER, James P, SAVAGE, Sarah, BROTT, Marcia J, RUSSELL-EGGITT, Isabelle, SUMMERS, C. Gail, OETTING, William S

“…Oculocutaneous albinism (OCA) is a common human genetic condition resulting from mutations in at least twelve different genes. OCA1 results from mutations of…”
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Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors by Johnson, L’Aurelle A., Oetting, William S., Basu, Saonli, Prausa, Susie, Matas, Arthur, Jacobson, Pamala A.

“…Background Mycophenolic acid (MPA) is glucuronidated primarily by uridine diphosphate glucuronosyltransferase enzymes (UGT) 1A9 and 1A8. These enzymes are…”
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