Search Results - "Oetjen, Karolyn"

The distribution of T‐cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia by Williams, Patrick, Basu, Sreyashi, Garcia‐Manero, Guillermo, Hourigan, Christopher S., Oetjen, Karolyn A., Cortes, Jorge E., Ravandi, Farhad, Jabbour, Elias J., Al‐Hamal, Zainab, Konopleva, Marina, Ning, Jing, Xiao, Lianchun, Hidalgo Lopez, Juliana, Kornblau, Steve M., Andreeff, Michael, Flores, Wilmer, Bueso‐Ramos, Carlos, Blando, Jorge, Galera, Pallavi, Calvo, Katherine R., Al‐Atrash, Gheath, Allison, James P., Kantarjian, Hagop M., Sharma, Padmanee, Daver, Naval G.

“…Background Phenotypic characterization of immune cells in the bone marrow (BM) of patients with acute myeloid leukemia (AML) is lacking. Methods T‐cell…”
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TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche by Yao, Juo-Chin, Oetjen, Karolyn A, Wang, Tianjiao, Xu, Haoliang, Abou-Ezzi, Grazia, Krambs, Joseph R, Uttarwar, Salil, Duncavage, Eric J, Link, Daniel C

“…Myeloproliferative neoplasms (MPNs) are associated with significant alterations in the bone marrow microenvironment that include decreased expression of key…”
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IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry by Lu, Peng, Oetjen, Karolyn A., Bender, Diane E., Ruzinova, Marianna B., Fisher, Daniel A. C., Shim, Kevin G., Pachynski, Russell K., Brennen, W. Nathaniel, Oh, Stephen T., Link, Daniel C., Thorek, Daniel L. J.

“…Imaging Mass Cytometry (IMC) is an emerging multiplexed imaging technology for analyzing complex microenvironments using more than 40 molecularly-specific…”
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Predisposition to hematologic malignancies in patients with xeroderma pigmentosum by Oetjen, Karolyn A, Levoska, Melissa A, Tamura, Deborah, Ito, Sawa, Douglas, Dorothea, Khan, Sikandar G, Calvo, Katherine R, Kraemer, Kenneth H, DiGiovanna, John J

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Immunological effects of hypomethylating agents by Lindblad, Katherine E, Goswami, Meghali, Hourigan, Christopher S, Oetjen, Karolyn A

“…Epigenetic changes resulting from aberrant methylation patterns are a recurrent observation in hematologic malignancies. Hypomethylating agents have a…”
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Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry by Oetjen, Karolyn A, Lindblad, Katherine E, Goswami, Meghali, Gui, Gege, Dagur, Pradeep K, Lai, Catherine, Dillon, Laura W, McCoy, J Philip, Hourigan, Christopher S

“…New techniques for single-cell analysis have led to insights into hematopoiesis and the immune system, but the ability of these techniques to cross-validate…”
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IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function by Li, Sidan, Yao, Juo-Chin, Oetjen, Karolyn A., Krambs, Joseph R., Xia, Jun, Zhang, Jingzhu, Schmidt, Amy P., Helton, Nichole M., Fulton, Robert S., Heath, Sharon E., Turnbull, Isaiah R., Mbalaviele, Gabriel, Ley, Timothy J., Walter, Matthew J., Link, Daniel C.

“…•TLR1/2 signaling in bone marrow DCs results in expansion of HSPCs with reduced repopulating activity through IL-1β production.•Bone marrow DCs in patients…”
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Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia by Goswami, Meghali, Gui, Gege, Dillon, Laura W, Lindblad, Katherine E, Thompson, Julie, Valdez, Janet, Kim, Dong-Yun, Ghannam, Jack Y, Oetjen, Karolyn A, Destefano, Christin B, Smith, Dana M, Tekleab, Hanna, Li, Yeusheng, Dagur, Pradeep, Hughes, Thomas, Marté, Jennifer L, del Rivero, Jaydira, Klubo-Gwiezdzinksa, Joanna, Gulley, James L, Calvo, Katherine R, Lai, Catherine, Hourigan, Christopher S

“…BackgroundThe powerful ‘graft versus leukemia’ effect thought partly responsible for the therapeutic effect of allogeneic hematopoietic cell transplantation in…”
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Mortality‐associated immunological abnormalities in trichothiodystrophy: correlation of reduced levels of immunoglobulin and neutrophils with poor patient survival by Randall, Grant, Kraemer, Kenneth H., Pugh, Jennifer, Tamura, Deborah, DiGiovanna, John J., Khan, Sikandar G., Oetjen, Karolyn A.

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Management of acute promyelocytic leukemia in the setting of acute COVID-19 infection by Shim, Kevin G, Crain, Mallory, Augustin, Kristan, Oetjen, Karolyn A

“…Acute promyelocytic leukemia (APL) often presents with significant coagulopathy which may result in both hemorrhagic and thrombotic complications. The…”
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Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture by Gestwicki, Jason E, Cairo, Christopher W, Strong, Laura E, Oetjen, Karolyn A, Kiessling, Laura L

“…Multivalent ligands can function as inhibitors or effectors of biological processes. Potent inhibitory activity can arise from the high functional affinities…”
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Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation by Tague, Laneshia K, Oetjen, Karolyn A, Mahadev, Anirudh, Walter, Matthew J, Anthony, Hephzibah, Kreisel, Daniel, Link, Daniel C, Gelman, Andrew E

“…BACKGROUNDCellular stressors influence the development of clonal hematopoiesis (CH). We hypothesized that environmental, inflammatory, and genotoxic stresses…”
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Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry by Oetjen, Karolyn A., Lindblad, Katherine E., Goswami, Meghali, Gui, Gege, Dagur, Pradeep K., Lai, Catherine, Dillon, Laura W., McCoy, J. Philip, Hourigan, Christopher S.

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Identifying the Trigger of c-IAPs: Structural and Functional Characterization of CARD-Mediated Modulation of Ubiquitin Ligase Activity by Oetjen, Karolyn A., Duckett, Colin S.

“…In this issue of Molecular Cell, Lopez et al. (2011) examine the caspase-recruitment domain (CARD) of c-IAP1 to reveal an intriguing mechanism in which…”
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Genomic landscape of TP53-mutated myeloid malignancies by Abel, Haley J., Oetjen, Karolyn A., Miller, Christopher A., Ramakrishnan, Sai M., Day, Ryan B., Helton, Nichole M., Fronick, Catrina C., Fulton, Robert S., Heath, Sharon E., Tarnawsky, Stefan P., Nonavinkere Srivatsan, Sridhar, Duncavage, Eric J., Schroeder, Molly C., Payton, Jacqueline E., Spencer, David H., Walter, Matthew J., Westervelt, Peter, DiPersio, John F., Ley, Timothy J., Link, Daniel C.

“…•Telomere content is increased in TP53-mutated AML/MDS compared with other AMLs, implicating altered telomere maintenance for pathogenesis.•Alterations of ETV6…”
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Cytoprotective effects of IAPs revealed by a small molecule antagonist by Galbán, Stefanie, Hwang, Clara, Rumble, Julie M, Oetjen, Karolyn A, Wright, Casey W, Boudreault, Alain, Durkin, Jon, Gillard, John W, Jaquith, James B, Morris, Stephen J, Duckett, Colin S

“…Deregulated expression of members of the IAP (inhibitor of apoptosis) family has been identified in a wide variety of neoplastic cells, and synthetic IAP…”
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Persistence of skewed X-chromosome inactivation in pre-B acute lymphoblastic leukemia of a female ATRX mutation carrier by Bradley, Christian P., Chen, Cai, Oetjen, Karolyn A., Yan, Cheng, Panjwani, Reema, Hauffe, Sara, Calvo, Katherine R., Yuan, Constance, Patel, Prapti Arvind, Montgomery, Nathan D., Foster, Matthew C., Battiwalla, Minoo, Barrett, A.John, Gibbons, Richard J., Ito, Sawa

“…•Leukemic blasts of a female carrier of an ATRX germline mutation have persistently skewed inactivation of the X chromosome.•Germline mutation in leukemia…”
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Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection by Sheela, Sheenu, Ito, Sawa, Strich, Jeffrey R., Manion, Maura, Montemayor-Garcia, Celina, Wang, Hao-Wei, Oetjen, Karolyn A., West, Kamile A., Barrett, Austin J., Parta, Mark, Gea-Banacloche, Juan, Holland, Steven M., Hourigan, Christopher S., Lai, Catherine

“…Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an…”
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Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP) by Rumble, Julie M., Oetjen, Karolyn A., Stein, Paul L., Schwartzberg, Pamela L., Moore, Bethany B., Duckett, Colin S.

“…Mutations in the X-linked inhibitor of apoptosis ( XIAP) have recently been identified in patients with the rare genetic disease, X-linked lymphoproliferative…”
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Increased Incidence of Clonal Hematopoiesis in Lung Transplant Recipients Involves DNA Damage Response Genes by Tague, Laneshia, Oetjen, Karolyn A., Mahadev, Anirudh, Link, Daniel C., Gelman, Andrew E

“…Lung transplant recipients receive lifelong immunosuppression that includes a calcineurin inhibitor (tacrolimus or cyclosporine), an anti-proliferative agent…”
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