Search Results - "Oesch, Franz"

Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat by Oesch, Franz, Fruth, Daniela, Hengstler, Jan G., Fabian, Eric, Berger, Franz Ingo, Landsiedel, Robert

“…N -vinyl pyrrolidone (NVP) is produced up to several thousand tons per year as starting material for the production of polymers to be used in pharmaceutics,…”
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Genotoxicity investigations on nanomaterials by Oesch, Franz, Landsiedel, Robert

“…This review is based on the lecture presented at the April 2010 nanomaterials safety assessment Postsatellite to the 2009 EUROTOX Meeting and summarizes…”
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Extrahepatic metabolism at the body's internal-external interfaces by Gundert-Remy, Ursula, Bernauer, Ulrike, Blömeke, Brunhilde, Döring, Barbara, Fabian, Eric, Goebel, Carsten, Hessel, Stefanie, Jäckh, Christine, Lampen, Alfonso, Oesch, Franz, Petzinger, Ernst, Völkel, Wolfgang, Roos, Peter H.

“…Abstract In general, xenobiotic metabolizing enzymes (XMEs) are expressed in lower levels in the extrahepatic tissues than in the liver, making the former less…”
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Xenobiotica-metabolizing enzyme induction potential of chemicals in animal studies: NanoString nCounter gene expression and peptide group-specific immunoaffinity as accelerated and economical substitutions for enzyme activity determinations? by Riffle, Brandy, Oesch, Franz, Heckmanns, Annika, Fabian, Eric, Wang, Mao, Samuga, Anita, Ren, Peifeng, Hammer, Helen, Schmidt, Felix, Pötz, Oliver, van Ravenzwaay, Bennard, Landsiedel, Robert

“…Xenobiotica-metabolizing enzyme (XME) induction is a relevant biological/biochemical process vital to understanding the toxicological profile of xenobiotics…”
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Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations by Landsiedel, Robert, Ma-Hock, Lan, Van Ravenzwaay, Ben, Schulz, Markus, Wiench, Karin, Champ, Samantha, Schulte, Stefan, Wohlleben, Wendel, Oesch, Franz

“…Abstract Titanium dioxide and zinc oxide nanomaterials, used as UV protecting agents in sunscreens, were investigated for their potential genotoxicity in in…”
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Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron by Efferth, Thomas, Benakis, Achille, Romero, Marta R., Tomicic, Maja, Rauh, Rolf, Steinbach, Daniel, Häfer, Ralf, Stamminger, Thomas, Oesch, Franz, Kaina, Bernd, Marschall, Manfred

“…Iron(II) heme-mediated activation of the peroxide bond of artemisinins is thought to generate the radical oxygen species responsible for their antimalarial…”
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Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities by Efferth, Thomas, Oesch, Franz

“…The oleogum resins of Boswellia species known as frankincense have been used for ages in traditional medicine in India, China and the Arabian world independent…”
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The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases by Efferth, Thomas, Oesch, Franz

“…The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this…”
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Aryl Hydrocarbon Receptor Activation by cAMP vs. Dioxin: Divergent Signaling Pathways by Oesch-Bartlomowicz, Barbara, Huelster, Andrea, Wiss, Oliver, Antoniou-Lipfert, Patricia, Dietrich, Cornelia, Arand, Michael, Weiss, Carsten, Bockamp, Ernesto, Oesch, Franz, Conney, Allan H.

“…Even before the first vertebrates appeared on our planet, the aryl hydrocarbon receptor (AHR) gene was present to carry out one or more critical life…”
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Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts by Faust, Dagmar, Schmitt, Christina, Oesch, Franz, Oesch-Bartlomowicz, Barbara, Schreck, Ilona, Weiss, Carsten, Dietrich, Cornelia

“…p38 MAP kinase is known to be activated by cellular stress finally leading to cell cycle arrest or apoptosis. Furthermore, a tumour suppressor role of p38 MAPK…”
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Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology by Efferth, Thomas, Oesch, Franz

“…Drug repurposing (or repositioning) is an emerging concept to use old drugs for new treatment indications. Phytochemicals isolated from medicinal plants have…”
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TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway by WEISS, Carsten, FAUST, Dagmar, DÜRK, Heike, KOLLURI, Siva Kumar, PELZER, Anke, SCHNEIDER, Sandra, DIETRICH, Cornelia, OESCH, Franz, GÖTTLICHER, Martin

“…The aryl hydrocarbon receptor (AhR) has a fundamental role during postnatal liver development and is essential for mediating dioxin toxicity. However, the…”
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The N-Terminal Domain of Mammalian Soluble Epoxide Hydrolase Is a Phosphatase by Cronin, Annette, Mowbray, Sherry, Dürk, Heike, Homburg, Shirli, Fleming, Ingrid, Fisslthaler, Beate, Oesch, Franz, Arand, Michael

“…The mammalian soluble epoxide hydrolase (sEH) is an enzyme with multiple functions, being implicated in detoxification of xenobiotic epoxides as well as in…”
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Characterization of c-kit Expression in Small Cell Lung Cancer: Prognostic and Therapeutic Implications by MICKE, Patrick, BASRAI, Maryam, HENGSTLER, Jan Georg, FALDUM, Andreas, BITTINGER, Fernando, RÖNNSTRAND, Lars, BLAUKAT, Andree, BEEH, Kai Michael, OESCH, Franz, FISCHER, Berthold, BUHL, Roland

“…Purpose: The tyrosine-kinase receptor c-kit and its ligand stem cell factor are coexpressed in many small cell lung cancer (SCLC) cell lines, leading to the…”
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Open letter to the German Research Foundation (DFG, Deutsche Forschungsgemeinschaft). Some comments on the recent exclusion of a renowned scientist from a toxicological commission by Oesch, Franz

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p38α MAPK is required for contact inhibition by FAUST, Dagmar, DOLADO, Ignacio, CUADRADO, Ana, OESCH, Franz, WEISS, Carsten, NEBREDA, Angel R, DIETRICH, Cornelia

“…Proliferation of nontransformed cells is regulated by cell–cell contacts, which are referred to as contact-inhibition. Despite its generally accepted…”
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Generation of human hepatocytes by stem cell technology: definition of the hepatocyte by Hengstler, Jan G, Brulport, Marc, Schormann, Wiebke, Bauer, Alexander, Hermes, Matthias, Nussler, Andreas K, Fandrich, Fred, Ruhnke, Maren, Ungefroren, Hendrik, Griffin, Louise, Bockamp, Ernesto, Oesch, Franz, von Mach, Marc-Alexander

“…Since 1999, numerous articles have reported the generation of hepatocytes from different types of extrahepatic stem or precursor cells. This opens exciting new…”
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Of mice and models: improved animal models for biomedical research by Bockamp, Ernesto, Maringer, Marko, Spangenberg, Christian, Fees, Stephan, Fraser, Stuart, Eshkind, Leonid, Oesch, Franz, Zabel, Bernhard

“…1 Laboratory of Molecular Mouse Genetics, Institute of Toxicology, Johannes Gutenberg-University Mainz, D-55131 Mainz 2 Laboratory of Molecular Genetics at…”
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Structure of Aspergillus niger epoxide hydrolase at 1.8 Å resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases by Zou, Jinyu, Hallberg, B Martin, Bergfors, Terese, Oesch, Franz, Arand, Michael, Mowbray, Sherry L, Jones, T Alwyn

“…Background: Epoxide hydrolases have important roles in the defense of cells against potentially harmful epoxides. Conversion of epoxides into less toxic and…”
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Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine (‘Ecstasy’) cytotoxicity by Carmo, Helena, Brulport, Marc, Hermes, Matthias, Oesch, Franz, Silva, Renata, Ferreira, Luísa M, Branco, Paula S, Boer, Douwe de, Remião, Fernando, Carvalho, Félix, Schön, Michael R, Krebsfaenger, Niels, Doehmer, Johannes, Bastos, Maria de Lourdes, Hengstler, Jan G

“…OBJECTIVESRemarkable interindividual differences in 3,4-methylenedioxymethamphetamine (‘Ecstasy’)-mediated toxicity have been reported in humans. Therefore, we…”
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