Search Results - "Oertel, Wolfgang H."

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder by Heintz‐Buschart, Anna, Pandey, Urvashi, Wicke, Tamara, Sixel‐Döring, Friederike, Janzen, Annette, Sittig‐Wiegand, Elisabeth, Trenkwalder, Claudia, Oertel, Wolfgang H., Mollenhauer, Brit, Wilmes, Paul

“…ABSTRACT Background Increasing evidence connects the gut microbiota and the onset and/or phenotype of Parkinson's disease (PD). Differences in the abundances…”
Get full text

Recent advances in treating Parkinson's disease [version 1; peer review: 2 approved] by Oertel, Wolfgang H

“…This article summarizes (1) the recent achievements to further improve symptomatic therapy of motor Parkinson's disease (PD) symptoms, (2) the still-few…”
Get full text

Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease by Meles, Sanne K, Oertel, Wolfgang H, Leenders, Klaus L

“…Parkinson's disease (PD) commences several years before the onset of motor features. Pathophysiological understanding of the pre-clinical or early prodromal…”
Get full text

Mitochondrial dysfunction in Parkinson's disease - a key disease hallmark with therapeutic potential by Henrich, Martin T, Oertel, Wolfgang H, Surmeier, D James, Geibl, Fanni F

“…Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson's disease (PD). However, strategies aimed at ameliorating…”
Get full text

The phenotypic spectrum of progressive supranuclear palsy: A retrospective multicenter study of 100 definite cases by Respondek, Gesine, Stamelou, Maria, Kurz, Carolin, Ferguson, Leslie W., Rajput, Alexander, Chiu, Wan Zheng, van Swieten, John C., Troakes, Claire, al Sarraj, Safa, Gelpi, Ellen, Gaig, Carles, Tolosa, Eduardo, Oertel, Wolfgang H., Giese, Armin, Roeber, Sigrun, Arzberger, Thomas, Wagenpfeil, Stefan, Höglinger, Günter U.

“…The phenotypic variability of progressive supranuclear palsy (PSP) may account for its frequent misdiagnosis, in particular in early stages of the disease…”
Get full text

How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy by Grimm, Max‐Joseph, Respondek, Gesine, Stamelou, Maria, Arzberger, Thomas, Ferguson, Leslie, Gelpi, Ellen, Giese, Armin, Grossman, Murray, Irwin, David J., Pantelyat, Alexander, Rajput, Alex, Roeber, Sigrun, Swieten, John C., Troakes, Claire, Antonini, Angelo, Bhatia, Kailash P., Colosimo, Carlo, Eimeren, Thilo, Kassubek, Jan, Levin, Johannes, Meissner, Wassilios G., Nilsson, Christer, Oertel, Wolfgang H., Piot, Ines, Poewe, Werner, Wenning, Gregor K., Boxer, Adam, Golbe, Lawrence I., Josephs, Keith A., Litvan, Irene, Morris, Huw R., Whitwell, Jennifer L., Compta, Yaroslau, Corvol, Jean‐Christophe, Lang, Anthony E., Rowe, James B., Höglinger, Günter U.

“…Background The Movement Disorder Society criteria for progressive supranuclear palsy define diagnostic allocations, stratified by certainty levels and clinical…”
Get full text

Which ante mortem clinical features predict progressive supranuclear palsy pathology? by Respondek, Gesine, Kurz, Carolin, Arzberger, Thomas, Compta, Yaroslau, Englund, Elisabet, Ferguson, Leslie W., Gelpi, Ellen, Giese, Armin, Irwin, David J., Meissner, Wassilios G., Nilsson, Christer, Pantelyat, Alexander, Rajput, Alex, Swieten, John C., Troakes, Claire, Josephs, Keith A., Lang, Anthony E., Mollenhauer, Brit, Müller, Ulrich, Whitwell, Jennifer L., Antonini, Angelo, Bhatia, Kailash P., Bordelon, Yvette, Corvol, Jean‐Christophe, Colosimo, Carlo, Dodel, Richard, Grossman, Murray, Kassubek, Jan, Krismer, Florian, Levin, Johannes, Lorenzl, Stefan, Morris, Huw, Nestor, Peter, Oertel, Wolfgang H., Rabinovici, Gil D., Rowe, James B., Eimeren, Thilo, Wenning, Gregor K., Boxer, Adam, Golbe, Lawrence I., Litvan, Irene, Stamelou, Maria, Höglinger, Günter U.

“…ABSTRACT Background Progressive supranuclear palsy (PSP) is a neuropathologically defined disease presenting with a broad spectrum of clinical phenotypes…”
Get full text

The REM sleep behavior disorder screening questionnaire-A new diagnostic instrument by Stiasny-Kolster, Karin, Mayer, Geert, Schäfer, Sylvia, Möller, Jens Carsten, Heinzel-Gutenbrunner, Monika, Oertel, Wolfgang H.

“…Many patients with assumed idiopathic REM sleep behavior disorder (RBD) may actually represent an early clinical manifestation of an evolving neurodegenerative…”
Get full text

Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model by Alvarez-Fischer, Daniel, Noelker, Carmen, Vulinović, Franca, Grünewald, Anne, Chevarin, Caroline, Klein, Christine, Oertel, Wolfgang H, Hirsch, Etienne C, Michel, Patrick P, Hartmann, Andreas

“…Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that…”
Get full text

The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease by Henderson, Michael X., Henrich, Martin T., Geibl, Fanni F., Oertel, Wolfgang H., Brundin, Patrik, Surmeier, D. James

“…Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and motor dysfunction has been attributed to loss of dopaminergic neurons…”
Get full text

Widespread microglial activation in multiple system atrophy by Kübler, Dorothee, Wächter, Tobias, Cabanel, Nicole, Su, Zhangjie, Turkheimer, Federico E., Dodel, Richard, Brooks, David J., Oertel, Wolfgang H., Gerhard, Alexander

“…Background The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [11C](R)‐PK11195…”
Get full text

Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports by Oertel, Wolfgang H., Janzen, Annette, Henrich, Martin T., Geibl, Fanni F., Sittig, Elisabeth, Meles, Sanne K., Carli, Giulia, Leenders, Klaus, Booij, Jan, Surmeier, D. James, Timmermann, Lars, Strupp, Michael

“…Isolated REM Sleep Behavior Disorder (iRBD) is considered a prodrome of Parkinson’s disease (PD). We investigate whether the potentially disease-modifying…”
Get full text

Manual MRI morphometry in Parkinsonian syndromes by Möller, Leona, Kassubek, Jan, Südmeyer, Martin, Hilker, Rüdiger, Hattingen, Elke, Egger, Karl, Amtage, Florian, Pinkhardt, Elmar H., Respondek, Gesine, Stamelou, Maria, Möller, Franz, Schnitzler, Alfons, Oertel, Wolfgang H., Knake, Susanne, Huppertz, Hans‐Jürgen, Höglinger, Günter U.

“…ABSTRACT Background: Several morphometric magnetic resonance imaging parameters may serve for differential diagnosis of parkinsonism. The objective of this…”
Get full text

Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio by Politis, Marios, Oertel, Wolfgang H., Wu, Kit, Quinn, Niall P., Pogarell, Oliver, Brooks, David J., Bjorklund, Anders, Lindvall, Olle, Piccini, Paola

“…Graft‐induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with…”
Get full text

Impaired inhibitory Fcγ receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy by Tackenberg, Björn, Jelčić, Ilijas, Baerenwaldt, Anne, Oertel, Wolfgang H, Sommer, Norbert, Nimmerjahn, Falk, Lünemann, Jan D

“…The inhibitory Fc-γ receptor FcγRIIB, expressed on myeloid and B cells, has a critical role in the balance of tolerance and autoimmunity, and is required for…”
Get full text

Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial by Poewe, Werner H, MD, Rascol, Olivier, MD, Quinn, Niall, MD, Tolosa, Eduardo, MD, Oertel, Wolfgang H, MD, Martignoni, Emilia, MD, Rupp, Markus, MD, Boroojerdi, Babak, MD

“…Summary Background Continuous dopaminergic drug delivery is an unmet medical need in advanced Parkinson's disease. The aim of this trial—Clinical Efficacy of…”
Get full text

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults by Joshi, Rajiv L, Hartmann, Andreas, Prochiantz, Alain, Alvarez-Fischer, Daniel, Fuchs, Julia, Castagner, François, Stettler, Olivier, Massiani-Beaudoin, Olivia, Moya, Kenneth L, Bouillot, Colette, Oertel, Wolfgang H, Lombès, Anne, Faigle, Wolfgang

“…Homeobox proteins Engrailed-1 (En1) and Engrailed-2 (En2) are transcription factors that direct midbrain cell specification during development. Here, the…”
Get full text

Diffusion Tensor Imaging in Idiopathic REM Sleep Behavior Disorder Reveals Microstructural Changes in the Brainstem, Substantia Nigra, Olfactory Region, and Other Brain Regions by UNGER, Marcus M, BELKE, Marcus, OERTEL, Wolfgang H, KNAKE, Susanne, MENZLER, Katja, HEVERHAGEN, Johannes T, KEIL, Boris, STIASNY-KOLSTER, Karin, ROSENOW, Felix, DIEDERICH, Nico J, MAYER, Geert, MÖLLER, Jens C

“…Idiopathic rapid eye movement sleep behavior disorder (iRBD)--a parasomnia characterized by dream enactments--is a risk marker for the development of Parkinson…”
Get full text

Treatment of restless legs syndrome: An evidence-based review and implications for clinical practice by Trenkwalder, Claudia, Hening, Wayne A., Montagna, Pasquale, Oertel, Wolfgang H., Allen, Richard P., Walters, Arthur S., Costa, Joao, Stiasny-Kolster, Karin, Sampaio, Cristina

“…Only in the last three decades, the restless legs syndrome (RLS) has been examined in randomized controlled trials. The Movement Disorder Society (MDS)…”
Get full text

Identification of Restless Legs Syndrome Genes by Mutational Load Analysis by Tilch, Erik, Schormair, Barbara, Zhao, Chen, Salminen, Aaro V., Antic Nikolic, Ana, Holzknecht, Evi, Högl, Birgit, Poewe, Werner, Bachmann, Cornelius G., Paulus, Walter, Trenkwalder, Claudia, Oertel, Wolfgang H., Hornyak, Magdolna, Fietze, Ingo, Berger, Klaus, Lichtner, Peter, Gieger, Christian, Peters, Annette, Müller‐Myhsok, Bertram, Hoischen, Alexander, Winkelmann, Juliane, Oexle, Konrad

“…Objective Restless legs syndrome is a frequent neurological disorder with substantial burden on individual well‐being and public health. Genetic risk loci have…”
Get full text