Search Results - "Oemar, B."

A phase I, randomized, double‐blind study to assess the safety, tolerability and efficacy of the topical RORC2 inverse agonist PF‐06763809 in participants with mild‐to‐moderate plaque psoriasis by Berstein, G., Zhang, Y., Berger, Z., Kieras, E., Li, G., Samuel, A., Yeoh, T., Dowty, H., Beaumont, K., Wigger‐Alberti, W., Mackensen, Y., Kroencke, U., Hamscho, R., Garcet, S., Krueger, J. G., Banfield, C., Oemar, B.

“…Summary Background Transcription factor retinoic acid‐related orphan receptor 2 (RORC2/RORγT) mediates interleukin (IL)‐17A and IL‐17F expression. IL‐17A plays…”
Get full text

Expression of connective tissue growth factor in human renal fibrosis by Ito, Yasuhiko, Aten, Jan, Bende, Richard J., Oemar, Barry S., Rabelink, Ton J., Weening, Jan J., Goldschmeding, Roel

“…Expression of connective tissue growth factor in human renal fibrosis. Chronic renal failure may occur in etiologically diverse renal diseases and can be…”
Get full text

Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis by OEMAR, B. S, TSCHUDI, M. R, GODOY, N, BROVKOVICH, V, MALINSKI, T, LÜSCHER, T. F

“…NO regulates vascular tone and structure, platelets, and monocytes. NO is synthesized by endothelial NO synthase (eNOS). Endothelial dysfunction occurs in…”
Get full text

Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels by BONGGWAN SEO, OEMAR, B. S, SIEBENMANN, R, VON SEGESSER, L, LÜSCHER, T. F

“…Endothelin (ET)-1 has potent vascular effects. Two endothelin receptors have been cloned, namely, the ETA receptor, which preferentially binds ET-1, and the…”
Get full text

Human connective tissue growth factor is expressed in advanced atherosclerotic lesions by OEMAR, B. S, WERNER, A, GARNIER, J.-M, DO, D.-D, GODOY, N, NAUCK, M, MÄRZ, W, RUPP, J, PECH, M, LÜSCHER, T. F

“…Atherosclerosis affects certain but not all vascular beds of the human circulation. Its molecular mechanisms are only partially understood. Human connective…”
Get full text

Connective Tissue Growth Factor: Friend or Foe? by Oemar, Barry S, Luscher, Thomas F

“…Connective tissue growth factor (CTGF) is a novel cysteine-rich, secreted peptide, which is implicated in human atherosclerosis and fibrotic disorders such as…”
Get full text

Pulsatile Stretch Stimulates Superoxide Production and Activates Nuclear Factor-kappa B in Human Coronary Smooth Muscle by Hishikawa, Keiichi, Oemar, Barry S, Yang, Zhihong

“…There is increasing evidence that oxidative stress is of pathophysiological importance in cardiovascular disease. Mechanical forces such as pulsatility may…”
Get full text

Different proliferative properties of smooth muscle cells of human arterial and venous bypass vessels: Role of PDGF receptors, mitogen-activated protein kinase, and cyclin-dependent kinase inhibitors by YANG, Z, OEMAR, B. S, CARREL, T, KIPFER, B, JULMY, F, LÜSCJER, T. F

“…Internal mammary artery (IMA) bypass grafts have a higher patency than saphenous vein (SV) grafts. Intimal hyperplasia of SV grafts is due to smooth muscle…”
Get full text

Overexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cells by HISHIKAWA, K, OEMAR, B. S, TANNER, F. C, NAKAKI, T, FUJII, T, LÜSCHER, T. F

“…Connective tissue growth factor (CTGF) is expressed at very high levels particularly in the shoulder of human atherosclerotic lesions but not in normal blood…”
Get full text

Static Pressure Regulates Connective Tissue Growth Factor Expression in Human Mesangial Cells by Hishikawa, K, Oemar, B S, Nakaki, T

“…Connective tissue growth factor (CTGF) is overexpressed in a variety of fibrotic disorders such as renal fibrosis and atherosclerosis. Fibrosis is a common…”
Get full text

Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF-7 by Hishikawa, K, Oemar, B S, Tanner, F C, Nakaki, T, Lüscher, T F, Fujii, T

“…Connective tissue growth factor (CTGF) is a member of an emerging CCN gene family that is implicated in various diseases associated with fibro-proliferative…”
Get full text

Is interleukin-1 beta a triggering factor for restenosis? by Oemar, B S

Get full text

Regulation of insulin-like growth factor I receptors in diabetic mesangial cells by OEMAR, B. S, FOELLMER, H. G, HODGDON-ANANDANT, L, ROSENZWEIG, S. A

“…Mesangial cells are thought to play a central role in the renal complications of diabetes mellitus. Insulin-like growth factor I (IGF-I) has been found to…”
Get full text

Infliximab Therapy in Patients with Chronic Sarcoidosis and Pulmonary Involvement by Baughman, Robert P, Drent, Marjolein, Kavuru, Mani, Judson, Marc A, Costabel, Ulrich, du Bois, Roland, Albera, Carlo, Brutsche, Martin, Davis, Gerald, Donohue, James F, Muller-Quernheim, Joachim, Schlenker-Herceg, Rozsa, Flavin, Susan, Lo, Kim Hung, Oemar, Barry, Barnathan, Elliot S, on behalf of Sarcoidosis Investigators

“…Evidence suggests that tumor necrosis factor (TNF)-alpha plays an important role in the pathophysiology of sarcoidosis. To assess the efficacy of infliximab in…”
Get full text

Platelet-Derived Growth Factor-Induced Vasodilatation in Mesenteric Resistance Arteries by Nitric Oxide: Blunted Response in Spontaneous Hypertension by Takase, Hiroyuki, Oemar, Barry S, Pech, Michael, Lüscher, Thomas F

“…Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth-muscle cells, but its effects on vasomotion remain controversial. Both…”
Get full text

17 beta-Estradiol and smooth muscle cell proliferation in aortic cells of male and female rats by Espinosa, E, Oemar, B S, Lüscher, T F

“…The low incidence of cardiovascular disease in women before menopause or during hormone replacement therapy suggests a protective effect of estrogens. The…”
Get full text

Insulin-like growth factor-1 induces tyrosyl phosphorylation of nuclear proteins by OEMAR, B. S, LAW, N. M, ROSENZWEIG, S. A

“…Stimulation of mesangial cells with insulin-like growth factor-1 (IGF-1) resulted in the rapid tyrosyl phosphorylation of nuclear proteins as indicated by…”
Get full text

Emergency administration of abciximab for treatment of patients with acute ischemic stroke : Results of a randomized phase 2 trial by STROKE, Abciximab Emergent, INVESTIGATORS, Treatment Trial

“…Because of its success in treatment of acute cardiac ischemia, there is interest in the use of abciximab for treating patients with acute ischemic stroke. A…”
Get full text

Bimodal effects of angiotensin II on migration of human and rat smooth muscle cells. Direct stimulation and indirect inhibition via transforming growth factor-beta 1 by Liu, G, Espinosa, E, Oemar, B S, Lüscher, T F

“…Angiotensin II may be an important mediator of neointima formation in vascular disease. This study was designed to examine the mechanisms involved in…”
Get full text

Molecular and cellular mechanisms of atherosclerosis by Oemar, B S, Yang, Z, Lüscher, T F

“…At least three distinct cellular mechanisms are currently thought to be responsible for the initiation of atherosclerotic lesions in humans: (1) accumulation…”
Get more information