Search Results - "Oelze, Matthias"

New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease by Daiber, Andreas, Xia, Ning, Steven, Sebastian, Oelze, Matthias, Hanf, Alina, Kröller-Schön, Swenja, Münzel, Thomas, Li, Huige

“…The Global Burden of Disease Study identified cardiovascular risk factors as leading causes of global deaths and life years lost. Endothelial dysfunction…”
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The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity by Oelze, Matthias, Kröller-Schön, Swenja, Welschof, Philipp, Jansen, Thomas, Hausding, Michael, Mikhed, Yuliya, Stamm, Paul, Mader, Michael, Zinßius, Elena, Agdauletova, Saule, Gottschlich, Anna, Steven, Sebastian, Schulz, Eberhard, Bottari, Serge P, Mayoux, Eric, Münzel, Thomas, Daiber, Andreas

“…In diabetes, vascular dysfunction is characterized by impaired endothelial function due to increased oxidative stress. Empagliflozin, as a selective…”
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Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease by Münzel, Thomas, Daiber, Andreas, Kröller-Schön, Swenja, Vujacic-Mirski, Ksenija, Bayo Jimenez, Maria Teresa, Kuntic, Marin, Kalinovic, Sanela, Oelze, Matthias, Frenis, Katie, Steven, Sebastian, Helmstädter, Johanna

“…Cardiovascular disease is a leading cause of death and reduced quality of life, proven by the latest data of the Global Burden of Disease Study, and is only…”
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The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes by Hanf, Alina, Oelze, Matthias, Manea, Adrian, Li, Huige, Münzel, Thomas, Daiber, Andreas

“…The anthracycline doxorubicin (DOX) is widely used in cancer therapy with the limitation of cardiotoxicity leading to the development of congestive heart…”
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Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice by Münzel, Thomas, Daiber, Andreas, Steven, Sebastian, Tran, Lan P, Ullmann, Elisabeth, Kossmann, Sabine, Schmidt, Frank P, Oelze, Matthias, Xia, Ning, Li, Huige, Pinto, Antonio, Wild, Philipp, Pies, Kai, Schmidt, Erwin R, Rapp, Steffen, Kröller-Schön, Swenja

“…Epidemiological studies indicate that traffic noise increases the incidence of coronary artery disease, hypertension and stroke. The underlying mechanisms…”
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Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation by Kröller-Schön, Swenja, Daiber, Andreas, Steven, Sebastian, Oelze, Matthias, Frenis, Katie, Kalinovic, Sanela, Heimann, Axel, Schmidt, Frank P, Pinto, Antonio, Kvandova, Miroslava, Vujacic-Mirski, Ksenija, Filippou, Konstantina, Dudek, Markus, Bosmann, Markus, Klein, Matthias, Bopp, Tobias, Hahad, Omar, Wild, Philipp S, Frauenknecht, Katrin, Methner, Axel, Schmidt, Erwin R, Rapp, Steffen, Mollnau, Hanke, Münzel, Thomas

“…Abstract Aims Aircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation noise increases the incidence of coronary…”
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Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases by Daiber, Andreas, Kröller-Schön, Swenja, Oelze, Matthias, Hahad, Omar, Li, Huige, Schulz, Rainer, Steven, Sebastian, Münzel, Thomas

“…Environmental pollution and non-chemical stressors such as mental stress or traffic noise exposure are increasingly accepted as health risk factors with…”
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Lysozyme M―Positive Monocytes Mediate Angiotensin II―Induced Arterial Hypertension and Vascular Dysfunction by WENZEL, Philip, KNORR, Maike, OELZE, Matthias, GRABBE, Stephan, JONULEIT, Helmut, BECKER, Christian, DAIBER, Andreas, WAISMAN, Ari, MÜNZEL, Thomas, KOSSMANN, Sabine, STRATMANN, Jan, HAUSDING, Michael, SCHUHMACHER, Swenja, KARBACH, Susanne H, SCHWENK, Melanie, YOGEV, Nir, SCHULZ, Eberhard

“…Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomonocytic cells into the vessel wall, and stimulates both…”
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The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats by Steven, Sebastian, Oelze, Matthias, Hanf, Alina, Kröller-Schön, Swenja, Kashani, Fatemeh, Roohani, Siyer, Welschof, Philipp, Kopp, Maximilian, Gödtel-Armbrust, Ute, Xia, Ning, Li, Huige, Schulz, Eberhard, Lackner, Karl J., Wojnowski, Leszek, Bottari, Serge P., Wenzel, Philip, Mayoux, Eric, Münzel, Thomas, Daiber, Andreas

“…Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction and cardiovascular disease in diabetes. Recent data…”
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Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase-Implications for Diabetes Progression by Daiber, Andreas, Steven, Sebastian, Vujacic-Mirski, Ksenija, Kalinovic, Sanela, Oelze, Matthias, Di Lisa, Fabio, Münzel, Thomas

“…Oxidative stress plays a key role for the development of cardiovascular, metabolic, and neurodegenerative disease. This concept has been proven by using the…”
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Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species-studies in white blood cells and in animal models by Kröller-Schön, Swenja, Steven, Sebastian, Kossmann, Sabine, Scholz, Alexander, Daub, Steffen, Oelze, Matthias, Xia, Ning, Hausding, Michael, Mikhed, Yuliya, Zinssius, Elena, Mader, Michael, Stamm, Paul, Treiber, Nicolai, Scharffetter-Kochanek, Karin, Li, Huige, Schulz, Eberhard, Wenzel, Philip, Münzel, Thomas, Daiber, Andreas

“…Oxidative stress is involved in the development of cardiovascular disease. There is a growing body of evidence for a crosstalk between different enzymatic…”
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Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease by Karbach, Susanne, Croxford, Andrew L, Oelze, Matthias, Schüler, Rebecca, Minwegen, Daniel, Wegner, Joanna, Koukes, Lija, Yogev, Nir, Nikolaev, Alexei, Reiig, Sonja, Ullmann, Alexander, Knorr, Maike, Waldner, Maximilian, Neurath, Markus F, Li, Huige, Wu, Zhixiong, Brochhausen, Christoph, Scheller, Jürgen, Rose-John, Stefan, Piotrowski, Carolin, Bechmann, Ingo, Radsak, Markus, Wild, Philipp, Daiber, Andreas, von Stebut, Esther, Wenzel, Philip, Waisman, Ari, Münzel, Thomas

“…OBJECTIVE—Interleukin (IL)-17A is regarded as an important cytokine to drive psoriasis, an inflammatory skin disease marked by increased cardiovascular…”
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Stimulatory TSH-Receptor Antibodies and Oxidative Stress in Graves Disease by Diana, Tanja, Daiber, Andreas, Oelze, Matthias, Neumann, Susanne, Olivo, Paul D, Kanitz, Michael, Stamm, Paul, Kahaly, George J

“…We hypothesized that TSH-receptor (TSHR) stimulating antibodies (TSAbs) are involved in oxidative stress mechanisms in patients with Graves disease (GD)…”
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Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system by Daiber, Andreas, Oelze, Matthias, Steven, Sebastian, Kröller-Schön, Swenja, Münzel, Thomas

“…Reactive oxygen and nitrogen species (RONS such as H O , nitric oxide) confer redox regulation of essential cellular functions (e.g. differentiation,…”
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Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in Aging by Oelze, Matthias, Kröller-Schön, Swenja, Steven, Sebastian, Lubos, Edith, Doppler, Christopher, Hausding, Michael, Tobias, Silke, Brochhausen, Christoph, Li, Huige, Torzewski, Michael, Wenzel, Philip, Bachschmid, Markus, Lackner, Karl J, Schulz, Eberhard, Münzel, Thomas, Daiber, Andreas

“…Recently, we demonstrated that gene ablation of mitochondrial manganese superoxide dismutase and aldehyde dehydrogenase-2 markedly contributed to age-related…”
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Inflammatory Monocytes Determine Endothelial Nitric-oxide Synthase Uncoupling and Nitro-oxidative Stress Induced by Angiotensin II by Kossmann, Sabine, Hu, Hanhan, Steven, Sebastian, Schönfelder, Tanja, Fraccarollo, Daniela, Mikhed, Yuliya, Brähler, Melanie, Knorr, Maike, Brandt, Moritz, Karbach, Susanne H., Becker, Christian, Oelze, Matthias, Bauersachs, Johann, Widder, Julian, Münzel, Thomas, Daiber, Andreas, Wenzel, Philip

“…Endothelial nitric-oxide synthase (eNOS) uncoupling and increased inducible NOS (iNOS) activity amplify vascular oxidative stress. The role of inflammatory…”
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Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects by Frenis, Katie, Helmstädter, Johanna, Ruan, Yue, Schramm, Eva, Kalinovic, Sanela, Kröller-Schön, Swenja, Bayo Jimenez, Maria Teresa, Hahad, Omar, Oelze, Matthias, Jiang, Subao, Wenzel, Philip, Sommer, Clemens J., Frauenknecht, Katrin B. M., Waisman, Ari, Gericke, Adrian, Daiber, Andreas, Münzel, Thomas, Steven, Sebastian

“…Aircraft noise induces vascular and cerebral inflammation and oxidative stress causing hypertension and cardiovascular/cerebral dysfunction. With the present…”
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Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension by Kossmann, Sabine, Lagrange, Jeremy, Jäckel, Sven, Jurk, Kerstin, Ehlken, Moritz, Schönfelder, Tanja, Weihert, Yvonne, Knorr, Maike, Brandt, Moritz, Xia, Ning, Li, Huige, Daiber, Andreas, Oelze, Matthias, Reinhardt, Christoph, Lackner, Karl, Gruber, Andras, Monia, Brett, Karbach, Susanne H, Walter, Ulrich, Ruggeri, Zaverio M, Renné, Thomas, Ruf, Wolfram, Münzel, Thomas, Wenzel, Philip

“…Multicellular interactions of platelets, leukocytes, and the blood vessel wall support coagulation and precipitate arterial and venous thrombosis. High levels…”
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Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice by Xia, Ning, Daiber, Andreas, Habermeier, Alice, Closs, Ellen I, Thum, Thomas, Spanier, Gerrit, Lu, Qing, Oelze, Matthias, Torzewski, Michael, Lackner, Karl J, Münzel, Thomas, Förstermann, Ulrich, Li, Huige

“…A crucial cause of the decreased bioactivity of nitric oxide (NO) in cardiovascular diseases is the uncoupling of the endothelial NO synthase (eNOS) caused by…”
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Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin by Jansen, Thomas, Hortmann, Marcus, Oelze, Matthias, Opitz, Benjamin, Steven, Sebastian, Schell, Richard, Knorr, Maike, Karbach, Susanne, Schuhmacher, Swenja, Wenzel, Philip, Münzel, Thomas, Daiber, Andreas

“…Abstract Heme oxygenase-1 (HO-1) is highly protective in various pathophysiological states such as cardiovascular and neurodegenerative diseases. HO-1-derived…”
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