Search Results - "Oellerich, M"

Differential S-nitrosylation of proteins in Alzheimer’s disease by Zahid, S, Khan, R, Oellerich, M, Ahmed, N, Asif, A.R

“…Graphical abstract…”
Get full text

What do we need to obtain high quality circulating tumor DNA (ctDNA) for routine diagnostic test in oncology? – Considerations on pre-analytical aspects by the IFCC workgroup cfDNA by Danesi, R., Lo, Y.M.D., Oellerich, M., Beck, J., Galbiati, S., Re, M. Del, Lianidou, E., Neumaier, M., van Schaik, R.H.N.

“…•Preanalytical variables influence the quality and quantity of isolated cfDNA.•This paper compares preanalytical aspects published for cfDNA analysis.•Blood…”
Get full text

Donor-Derived Cell-Free DNA Is a Novel Universal Biomarker for Allograft Rejection in Solid Organ Transplantation by Beck, J, Oellerich, M, Schulz, U, Schauerte, V, Reinhard, L, Fuchs, U, Knabbe, C, Zittermann, A, Olbricht, C, Gummert, J.F, Shipkova, M, Birschmann, I, Wieland, E, Schütz, E

“…Abstract Background In solid organ transplantation, sensitive real-time biomarkers to assess the graft health are desirable to enable early intervention, for…”
Get full text

Population pharmacokinetics of mycophenolic acid in pediatric renal transplant patients using parametric and nonparametric approaches by Prémaud, A., Weber, L.T., Tönshoff, B., Armstrong, V.W., Oellerich, M., Urien, S., Marquet, P., Rousseau, A.

“…Mycophenolic acid (MPA) is an immunosuppressive drug widely used in the prevention of acute rejection in pediatric renal transplant recipients and is…”
Get full text

CD4+ immune response as a potential biomarker of patient reported inflammatory bowel disease (IBD) activity by Brandhorst, G., Weigand, S., Eberle, C., Raddatz, D., Karaus, M., Oellerich, M., Walson, P.D.

“…Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBDs) which are characterized by dysfunctional regulation of the immune…”
Get full text

Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: Implications for drug exposure in renal allograft recipients by Naesens, Maarten, Kuypers, Dirk R. J., Streit, Frank, Armstrong, Victor W., Oellerich, Michael, Verbeke, Kristin, Vanrenterghem, Yves

“…Background Exposure to mycophenolic acid (MPA) and its main metabolites (MPA 7‐O‐glucuronide [MPAG] and MPA acyl‐glucuronide [AcMPAG]) is characterized by a…”
Get full text

Acyl glucuronide drug metabolites: Toxicological and analytical implications by SHIPKOVA, Maria, ARMSTRONG, Victor William, OELLERICH, Michael, WIELAND, Eberhard

“…Although glucuronidation is generally considered a detoxification route of drug metabolism, the chemical reactivity of acyl glucuronides has been linked with…”
Get full text

Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes by Shipkova, M, Strassburg, C P, Braun, F, Streit, F, Gröne, H‐J, Armstrong, V W, Tukey, R H, Oellerich, M, Wieland, E

“…Mycophenolic acid (MPA) is primarily metabolized to a phenolic glucuronide (MPAG) as well as to two further minor metabolites: an acyl glucuronide (AcMPAG) and…”
Get full text

Inosine monophosphate dehydrogenase activity in paediatrics: age-related regulation and response to mycophenolic acid by Rother, A., Glander, P., Vitt, E., Czock, D., von Ahsen, N., Armstrong, V. W., Oellerich, M., Budde, K., Feneberg, R., Tönshoff, B., Weber, L. T.

“…Purpose Since many drug targets and metabolizing enzymes are developmentally regulated, we investigated a potential comparable regulation of inosine…”
Get full text

Plasma Concentrations of Mycophenolic Acid Acyl Glucuronide Are Not Associated with Diarrhea in Renal Transplant Recipients by Heller, T., Van Gelder, T., Budde, K., De Fijter, J. W., Kuypers, D., Arns, W., Schmidt, J., Rostaing, L., Powis, S. H., Claesson, K., MacPhee, I. A. M., Pohanka, E., Engelmayer, J., Brandhorst, G., Oellerich, M., Armstrong, V. W.

“…The aim of this study was to determine whether plasma concentrations of the acyl (AcMPAG) and phenolic (MPAG) glucuronide metabolites of mycophenolic acid…”
Get full text

Twelve-month evaluation of the clinical pharmacokinetics of total and free mycophenolic acid and its glucuronide metabolites in renal allograft recipients on low dose tacrolimus in combination with mycophenolate mofetil by KUYPERS, D. R. J, VANRENTERGHEM, Y, SQUIFFLET, J. P, MOURAD, M, ABRAMOWICZ, D, OELLERICH, M, ARMSTRONG, V, SHIPKOVA, M, DAEMS, J

“…The establishment of a rationale for therapeutic drug monitoring for mycophenolic acid (MPA) and outlining a therapeutic window remains a challenging task in…”
Get full text

Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney by Wolff, Natascha A., Burckhardt, Birgitta C., Burckhardt, Gerhard, Oellerich, Michael, Armstrong, Victor W.

“…Background. Mycophenolic acid (MPA), the active moiety of the prodrug mycophenolate mofetil, is widely used in immunosuppressive regimens after kidney, liver…”
Get full text

Genotyping of Eight Thiopurine Methyltransferase Mutations: Three-Color Multiplexing, "Two-Color/Shared" Anchor, and Fluorescence-quenching Hybridization Probe Assays Based on Thermodynamic Nearest-Neighbor Probe Design by Schutz, Ekkehard, von Ahsen, Nicolas, Oellerich, Michael

“…The inherited deficiency of thiopurine methyltransferase (TPMT) leads to severe myelosuppression in homozygous patients treated with thiopurine derivatives…”
Get full text

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient by Schütz, E, Gummert, J, Mohr, F, Oellerich, M

Get more information

Differential proteome and phosphoproteome signatures in human T-lymphoblast cells induced by sirolimus by Schultze, F. C., Petrova, D. T., Oellerich, M., Armstrong, V. W., Asif, A. R.

“…Objectives:  The present study was designed to investigate early proteome and phosphoproteome changes during inhibition of lymphocyte proliferation induced by…”
Get full text

The acyl glucuronide metabolite of mycophenolic acid inhibits the proliferation of human mononuclear leukocytes by Shipkova, M, Wieland, E, Schütz, E, Wiese, C, Niedmann, P.D, Oellerich, M, Armstrong, V.W

Get full text

Prenatal dexamethasone exposure in the common marmoset monkey enhances gene expression of antioxidant enzymes in the aorta of adult offspring by Atanasova, S, Wieland, E, Schlumbohm, C, Korecka, M, Shaw, L, von Ahsen, N, Fuchs, E, Oellerich, M, Armstrong, V

“…Human epidemiological studies have indicated that low birth weight associated with an adverse intrauterine environment is related to a greater incidence of…”
Get more information

Effect of the Antioxidant Idebenone on Adverse Events Under Mycophenolate Mofetil Therapy in a Rat Model by HELLER, Tanja, GEIDE, Anna, BONITZ, Ulrike, WEGNER, Ulrike, GRÖNE, Hermann-Josef, ARMSTRONG, Victor W, OELLERICH, Michael

“…Diarrhea and anemia are side effects of mycophenolic acid (MPA), but underlying mechanisms are not fully understood. Gene expression of major-alpha-hemoglobin…”
Get full text

Pharmacokinetics and safety of lidocaine and monoethylglycinexylidide in liposuction: a microdialysis study by Kenkel, Jeffrey M, Lipschitz, Avron H, Shepherd, Greene, Armstrong, Victor W, Streit, Frank, Oellerich, Michael, Luby, Maureen, Rohrich, Rod J, Brown, Spencer A

“…High doses of lidocaine are administered to patients undergoing liposuction. Monoethylglycinexylidide, the active metabolite of lidocaine, is 80 to 90 percent…”
Get full text

Prognostic value of the monoethylglycinexylidide (MEGX)-test prior to liver resection by Lorf, T, Schnitzbauer, A A, Schaefers, S K H, Scherer, M N, Schlitt, H J, Oellerich, M, Becker, H, Obed, A

“…The critical issue before major hepatic resection is to evaluate and detect patients with a potentially increased risk of hepatic failure. In this study the…”
Get more information