Search Results - "Oeller, Marc"

An open-source automated PEG precipitation assay to measure the relative solubility of proteins with low material requirement by Oeller, Marc, Sormanni, Pietro, Vendruscolo, Michele

“…The solubility of proteins correlates with a variety of their properties, including function, production yield, pharmacokinetics, and formulation at high…”
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Automated optimisation of solubility and conformational stability of antibodies and proteins by Rosace, Angelo, Bennett, Anja, Oeller, Marc, Mortensen, Mie M., Sakhnini, Laila, Lorenzen, Nikolai, Poulsen, Christian, Sormanni, Pietro

“…Biologics, such as antibodies and enzymes, are crucial in research, biotechnology, diagnostics, and therapeutics. Often, biologics with suitable functionality…”
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Automated optimization of the solubility of a hyper-stable α-amylase by Ali, Montader, Greenig, Matthew, Oeller, Marc, Atkinson, Misha, Xu, Xing, Sormanni, Pietro

“…Most successes in computational protein engineering to date have focused on enhancing one biophysical trait, while multi-trait optimization remains a…”
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Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids by Oeller, Marc, Kang, Ryan J. D., Bolt, Hannah L., Gomes dos Santos, Ana L., Weinmann, Annika Langborg, Nikitidis, Antonios, Zlatoidsky, Pavol, Su, Wu, Czechtizky, Werngard, De Maria, Leonardo, Sormanni, Pietro, Vendruscolo, Michele

“…Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs as they expand the available chemical space to…”
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Light-sheet fluorescence expansion microscopy: fast mapping of neural circuits at super resolution by Bürgers, Jana, Pavlova, Irina, Rodriguez-Gatica, Juan E, Henneberger, Christian, Oeller, Marc, Ruland, Jan A, Siebrasse, Jan P, Kubitscheck, Ulrich, Schwarz, Martin K

“…The goal of understanding the architecture of neural circuits at the synapse level with a brain-wide perspective has powered the interest in high-speed and…”
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Sequence-based prediction and measurement of pH-dependent protein solubility by Oeller, Marc, Sormanni, Pietro, Vendruscolo, Michele

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Sequence-based prediction of pH-dependent protein solubility using CamSol by Oeller, Marc, Kang, Ryan, Bell, Rosie, Ausserwöger, Hannes, Sormanni, Pietro, Vendruscolo, Michele

“…Abstract Solubility is a property of central importance for the use of proteins in research in molecular and cell biology and in applications in biotechnology…”
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OS-041-YI A spatiotemporal map of the hepatocyte proteome in alpha-1 antitrypsin deficiency by single-cell and visual proteomics by Rosenberger, Florian, Thorhauge, Katrine, Mädler, Sophia, Fromme, Malin, Weiss, Caroline, Oeller, Marc, Steigerwald, Sophia, Thielert, Marvin, Nordmann, Thierry, Detlefsen, Sönke, Boor, Peter, Fabián, Ondřej, Fraňková, Soňa, Krag, Aleksander, Strnad, Pavel, Mann, Matthias

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N‑Terminal Acetylation of α‑Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates by Bell, Rosie, Thrush, Rebecca J., Castellana-Cruz, Marta, Oeller, Marc, Staats, Roxine, Nene, Aishwarya, Flagmeier, Patrick, Xu, Catherine K., Satapathy, Sandeep, Galvagnion, Celine, Wilson, Mark R., Dobson, Christopher M., Kumita, Janet R., Vendruscolo, Michele

“…Parkinson’s disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational…”
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Bridging the Gap from Proteomics Technology to Clinical Application: Highlights from the 68th Benzon Foundation Symposium by Albrecht, Vincent, Müller-Reif, Johannes, Nordmann, Thierry M., Mund, Andreas, Schweizer, Lisa, Geyer, Philipp E., Niu, Lili, Wang, Juanjuan, Post, Frederik, Oeller, Marc, Metousis, Andreas, Bach Nielsen, Annelaura, Steger, Medini, Wewer Albrechtsen, Nicolai J., Mann, Matthias

“…The 68th Benzon Foundation Symposium brought together leading experts to explore the integration of mass spectrometry (MS)-based proteomics and artificial…”
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Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform by Erkamp, Nadia A., Oeller, Marc, Sneideris, Tomas, Ausserwoger, Hannes, Levin, Aviad, Welsh, Timothy J., Qi, Runzhang, Qian, Daoyuan, Lorenzen, Nikolai, Zhu, Hongjia, Sormanni, Pietro, Vendruscolo, Michele, Knowles, Tuomas P.J.

“…Protein-based biologics are highly suitable for drug development as they exhibit low toxicity and high specificity for their targets. However, for therapeutic…”
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Risk willingness in multiple system atrophy and Parkinson’s disease understanding patient preferences by Bernhardt, Alexander Maximilian, Oeller, Marc, Friedrich, Isabel, Kocakavuk, Emre, Nachman, Eliana, Peikert, Kevin, Roderigo, Malte, Rossmann, Andreas, Schröter, Tabea, Wilhelm, Lea Olivia, Prell, Tino, van Riesen, Christoph, Nieweler, Johanna, Katzdobler, Sabrina, Weiler, Markus, Jacobi, Heike, Warnecke, Tobias, Claus, Inga, Palleis, Carla, Breimann, Stephan, Falkenburger, Björn, Brandt, Moritz, Hermann, Andreas, Rumpf, Jost-Julian, Claßen, Joseph, Höglinger, Günter, Gandor, Florin, Levin, Johannes, Giese, Armin, Janzen, Annette, Oertel, Wolfgang Hermann

“…Disease-modifying therapeutics in the α-synucleinopathies multiple system atrophy (MSA) and Parkinson’s Disease (PD) are in early phases of clinical testing…”
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